Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"motoneuron"”.
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EXERCISE IS NEUROPROTECTIVE TO MOTONEURON DENDRITES FOLLOWING PARTIAL MOTONEURON DEPLETION VIA A MECHANISM DEPENDENT ON ANDROGEN RECEPTORS AT THE TARGET MUSCLE
Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. It has been previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and that treatment with testosterone …
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The Role of Raf-mediated Signalling Pathways for Motoneuron
… functions of the different Raf kinases in motoneurons during development, the expression, distribution and subcellular localization of Rafs in the spinal cord and the facial nucleus in brainstem of mice at various embryonic and postnatal stages were investigated. Moreover, we have …
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A Developmental Pathway for Epithelial-to-Motoneuron Transformation in C. Elegans
… in the differentiation of these cells into motoneurons through control of their proliferative state. Down-regulation of the Notch-dependent Hes1 and Hes5 transcriptional inhibitors in differentiating cells induces expression of the proneural bHLH transcription factors Olig2 and Ngn2, leading …
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The regulation of motoneuron survival in the tobacco hornworm, Manduca sexta
… 20-hydroxyecdysone, and in the case of the MN-12 motoneurons, by actions exerted by neighboring ganglia.
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Molecular and cellular regulation of motoneuron differentiation of human neural stem cells
… into choline acetyltransferase (ChAT) motoneurons in vitro and after transplantation into the rodent spinal cord in vivo. However, the mechanisms surrounding FHL-induced motoneuron differentiation of hNSCs are unknown. Thus, the overall goal for this thesis was to further understand the …
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Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS
… mice causes significantly more facial motoneuron (FMN) loss relative to wild type (WT), indicating that the immune system is neuroprotective. Further studies reveal that both CD4+ T cells and interleukin 10 (IL-10) act centrally to promote neuronal survival after injury. This study …
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The role of c-Jun N-terminal kinase one and two in motoneuron maturation and maintenance
During development motoneurons (MNs) undergo programmed cell death (PCD), and the molecular coordination of intracellular signaling and death execution pathways are prominent areas of research (Hamburger, 1958; Hollyday and Hamburger, 1976; Oppenheim, 1991; Oppenheim., 2005 ). Subgroups of the …
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Characterization of the Role of Differential Gene Expression and RNA Editing in Drosophila Tonic and Phasic Motoneuron Diversity
… of the tonic Ib and phasic Is glutamatergic motoneuron subtypes in the Drosophila 3rd instar larvae. These neurons display distinct morphological and electrophysiological properties, in addition to being easily accessible for imaging, electrophysiology, and genetic approaches, making them an …
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MOTONEURON MAINTENANCE DEFECTS AND NON-CELL AUTONOMOUS CONTRIBUTIONS BY SCHWANN CELLS IN ZEBRAFISH MUTANT AND MORPHANT MODELS FOR SPINAL MUSCULAR ATROPHY
Survival Motoneuron (SMN) protein deficiency results in motoneuron (MN) loss in Spinal Muscular Atrophy (SMA) patients. SMN is encoded by SMN1 and SMN2 which differ in a C6T nucleotide leading to differential splicing of exon 7. My novel zebrafish smn2 mutant established that C6T transition in …
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Identifizierung und Charakterisierung des krankheitsauslösenden Gens in einem Mausmodell für humane Motoneuronerkrankungen
Human motoneuron diseases can be classified according to their etiology (sporadic, familial), the appearance of clinical signs and disease progression. Corresponding to the disease patterns, one can distinguish diseases of the first motoneuron (e.g. spastic spinal paralyses), the second motoneuron …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
… the progeny born of NB4-2, GMC4-2a and the RP2 motoneuron. The loss of hkb results in altered GMC4-2a cell fate and faulty RP2 axon pathfinding. In addition to the RP2 motoneuron, hkb also regulates axon pathfinding of two other motoneurons deriving from NB4-2.
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The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
… the progeny born of NB4-2, GMC4-2a and the RP2 motoneuron. The loss of hkb results in altered GMC4-2a cell fate and faulty RP2 axon pathfinding. In addition to the RP2 motoneuron, hkb also regulates axon pathfinding of two other motoneurons deriving from NB4-2.
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Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
… of Ib tonic or Is phasic glutamatergic motoneurons that co-innervate postsynaptic muscles at Drosophila neuromuscular junctions (NMJs). After identifying drivers for each neuronal subtype, I performed ablation or genetic manipulations to alter neuronal activity and examined the effects …
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… Further examination of the aCC, RP3, and RP2 motoneurons revealed that the midline mutants commissureless, netrin, frazzled and roundabout disrupt dendritic growth cone guidance at the CNS midline. Specifically, frazzled and roundabout act cell autonomously to mediate dendritic attraction and …
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Spinal interneurons in sensorimotor integration
… terminals about 3/4 forming contacts with motoneurons. To achieve the second aim, 21 interneurons located in the intermediate zone and lamina VIII from 7 adult cats were characterised electrophysiologically and labelled intracellularly with Neurobiotin. Seventeen of these cells were …
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Analysis of the Mechanisms and Principles of Neural Development in the Drosophila
… features of synaptic formation. Examining the motoneurons that formed different types of boutons showed variances in the innervation patterns produced by the motoneurons. The motoneurons that developed the large synapses (type Ib) innervated one target, while the motoneurons that formed the …
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VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
… together with morphological alterations of motoneuronal phenotype. In this scenario, we decided to deeper investigate the role of VGSCs in neurite elongation, by taking advantage of the NSC34 cell line, an in vitro model often used in the study of motoneuron disease. Thus, we used two …
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Analysis of Postsynaptic Morphology During Neuromuscular Synaptogenesis in Drosophila Melanogaster
… clustered myopodia intermingle extensively with motoneuron growth cones. Myopodia clustering, but not their initial appearance, is dependent on the presence of motoneurons. When the rate of synaptic targeting at an identified muscle is lowered, myopodia clustering at the same muscle is also …
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