Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"morphogens"”.
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Morphogenetic signaling in growing tissues
… are ensured by signaling molecules as e.g. morphogens. Secreted from a restricted source, morphogens spread into the adjacent target tissue where they form a graded concentration profile. Upon binding of the morphogens to receptors on the cell surfaces, the morphogenetic signal is transduced …
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Fate, Phases, and Form in Vertebrate Organ Morphogenesis-Uncovering a Role of Morphogenesis at the Supracellular Scale
… prompting the question of what functional roles morphogens serve. found that morphogens enable the creation of membrane-less tissue compartments within the mesenchyme of the follicle with distinct biophysical properties, such as elasticity, viscosity and contractility. Specifically, fibroblast …
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Formation of morphogen gradients
Morphogens are signaling molecules that play a key role in animal development. They spread from a restricted source into an adjacent target tissue forming a concentration gradient. The fate of cells in the target tissue is determined by the local concentration of such morphogens. Morphogen …
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Removal of Pax6 from cortical progenitors renders them abnormally likely to switch fate in response to Sonic Hedgehog activity
… of neurodevelopment are also regulated by morphogens such as Sonic Hedgehog (Shh) that promotes ventralization of the ventral telencephalon (vTel), through diffusion to form a concentration gradient. Strikingly, when Pax6 is deleted, a subset of cortical progenitor cells that would normally …
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The glypican Dally binds to Lipophorin particles and increases Hedgehog signaling efficiency
… Lipoprotein particles bear lipid-linked morphogens on their surface and are required for long-range signaling activity of Wingless and Hedgehog. They also bind a wide variety of gpi-linked proteins. Whether any of these proteins affect morphogen signaling is unknown. Here, I show that the …
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Scaffold-Mediated Organization of Signal Transduction Networks
… in response to growth factors, cytokines, morphogens, and other extracellular stimuli. Given the ubiquitous nature of this signaling pathway, it is not clear how specialization with respect to various Raf-dependent phenomena is acquired. In theory, functional specificity could be achieved …
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Function of a C-rich region in the transcriptional regulation of the glycogen phosphorylase-2 gene in Dictyostelium discoideum
… development and is regulated by extracellular morphogens such as cyclic AMP (cAMP; Sucic et al., 1993) and differentiation induction factor (DIF; Yin et al., 1994a). These morphogens are known to be involved in regulating cellular differentiation and pattern formation in the multicellular …
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Discovery and Characterization of Novel Chemical Inhibitors of Wnt Ligand Production with Implications for Anti-Cancer Therapy
The widespread and indispensable nature of Wnt morphogens during early development has long been a focal point of embryogenesis research. More recently, pathway activation has been uncovered in adult stem cell niches and cancers arising from associated tissues. Consequently, interest has shifted …
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Endoplasmic Reticulum Morphoregulation Modulates Ca2+- Driven Brain Cell Functions
… neuronal pathologies, with mutations in some ER morphogens causing motor neurone diseases. The selective vulnerability of long axons highlights the significance of their extensive ER tubule-containing periphery for neuronal health, but the underlying pathophysiological mechanisms are yet to be …
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The Role for Proteoglycans in Regulating Embryonic Patterning and Morphogenesis
Growth factors and morphogens regulate embryonic patterning, cell fate specification, cell migration and morphogenesis. The activity and behaviour of these signalling molecules is regulated in the extracellular space through interactions with proteoglycans. Proteoglycans are high molecular-weight …
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TGF-beta signaling at the cellular junctions
… cells produce secreted signals termed morphogens, which traffic through the tissue until they are received by target, responding cells. Using the fruit fly Drosophila melanogaster as a model organism, I have studied transforming growth factor-beta (TGF-beta) signal from the secreting to …
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REGULATED UPTAKE OF BIOPOLYMERS Role of cell surface proteoglycans Implications for drug and gene delivery
… ligands, including polyamines, growth factors, morphogens, and microbes. This thesis deals with the role of proteoglycans in cellular internalization of charged biopolymers, i.e. the polyamine family of growth factors, HIV-Tat peptide, antimicrobial peptides, and nucleic acids. The presented …
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How the fas locus contributes to Rhodococcus fascians cytokinin production: an in-depth molecular and biochemical analysis
… pathway and the identity of the produced morphogens remained to be uncovered. Therefore, the main objectives of this research were to identify the bacterial cytokinins responsible for the R. fascians pathology, to unravel how they exerted their function, and to elucidate the role of the …
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Rarity of Novel microRNAs in the Mouse Inner Ear
… by molecular and cellular factors such as morphogens and transcription factors. Another class of gene regulators whose function in the inner ear is essential but not well understood is microRNAs. Previous microarray analyses of microRNAs in the mouse inner ear performed at postnatal …
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An NMR and molecular modelling study on the solution conformation of Heparan Sulphate: new insights into the relationship between structure and function
… role as a co-receptor for growth factors and morphogens. Due to the extreme difficulty in preparing homogeneous HS oligosaccharides for structural and functional studies, traditionally, oligosaccharides derived from the related molecule heparin are used as HS structural models. In this study a …
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Role of endocytic trafficking during Dpp gradient formation
Morphogens are secreted signalling molecules that are expressed in restricted groups of cells within the developing tissue. From there, they are secreted and travel throughout the target field and form concentration gradients. These concentration profiles endow receiving cells with positional …
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Investigating The In Vivo Role Of Wnt Acylation
Wnts are a family of morphogens that play diverse roles in embryonic patterning, the maintenance of adult stem cells, and the evolution of cancers. Mammalian genomes contain 19 unique Wnt proteins which undergo post-translational acylation at a highly-conserved serine residue. All Wnts bind to the …
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NOGGIN Transport in a Model Human Epiblast
… inhibitors regulates the spatial availability of morphogens during embryogenesis. My study shed light on an important and unexpected level of regulation for the transport of morphogen inhibitors whose role in spatially restricting the spread of morphogen signaling ultimately shapes the embryonic …
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts …
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Investigating the effects of Wnt/β-catenin Signalling on Melanoma Cell Metabolism and Mitochondrial Dynamics
Wnts are secreted morphogens that play pivotal roles in embryonic development, stem cell biology and a number of disease states including cancer. Most Wnts signal through a pathway that results in the stabilisation of an intracellular signalling molecule called β-catenin. In melanoma cells, …
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