Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"morphogen transport"”.
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Formation of morphogen gradients
Morphogens are signaling molecules that play a key role in animal development. They spread from a restricted source into an adjacent target tissue forming a concentration gradient. The fate of cells in the target tissue is determined by the local concentration of such morphogens. Morphogen …
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Investigating the Role of Dispatched in Hedgehog Ligand Transport and Delivery
… or regulatory mechanisms enabling Disp to transport and release Hh ligand. This dissertation aimed to narrow this gap and began with investigation into the role of Disp in a largely ignored mechanism of Hh ligand transport known as cytoneme-mediated morphogen transport. This method of …
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Morphogenetic signaling in growing tissues
… are ensured by signaling molecules as e.g. morphogens. Secreted from a restricted source, morphogens spread into the adjacent target tissue where they form a graded concentration profile. Upon binding of the morphogens to receptors on the cell surfaces, the morphogenetic signal is transduced …
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NOGGIN Transport in a Model Human Epiblast
… In this work, I interrogate the interplay of the morphogen/inhibitor pair BMP4/NOGGIN within our model of the polarized human embryonic disc. Here, I report the surprising discovery that in human epiblasts, NOGGIN and BMP4 were selectively secreted into opposite sides of the polarized epithelium, …