Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 173 for “"morphine"”.
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Pharmacokinetics and renal clearance of morphine and its two major metabolites, morphine-3-glucuronide and morphine-6-glucuronide in the rabbit
The pharmacokinetics of morphine and renal clearance of morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G) and morphine (M) were studied following intravenous (IV) administration of single doses of morphine (1.5 mg/kg) alone, in the presence of cimetidine as a loading dose (10 mg/kg) and …
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Clinical effects of long-term intrathecal morphine versus morphine/bupivacaine administration in cancer patients.
Contains fulltext : 18646.pdf (Publisher’s version ) (Open Access)
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Fungal biotransformation of morphine alkaloids
… the ability of certain fungi to biotransform morphine alkaloids into medicinally relevant intermediates. Fungal strains screened for their ability to affect biotransformation of morphine alkaloids include Cunninghamella echinulata, Helicostylum pirijorme, Pycnoporus sanguinea, Pycnoporus …
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Increased Microglial Reactivity Alters Morphine Analgesia
… and the microglial transcription factor Runx1 in morphine analgesia and in the development of adverse effects. My over-arching hypothesis is that increased microglial reactivity diminishes the analgesic potential of opioids, such as morphine. Here I show that repeated morphine causes a …
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Self-Stimulation and Morphine Abstinence in the Rat.
To test the effects of morphine abstinence on shuttlebox self-stimulation, rats were implanted with either a morphine or placebo pellet. Naloxone or saline was administered 48 hours later and animals were observed briefly for abstinence behaviors. Immediately following the observation period, …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… both the role of adult DG neurogenesis in morphine-related behaviors and the effects of self-administered opiates (morphine and heroin) on adult DG neurogenesis. I first explore the background literature important in the work completed within this dissertation (Chapter 1). Next, using a …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… both the role of adult DG neurogenesis in morphine-related behaviors and the effects of self-administered opiates (morphine and heroin) on adult DG neurogenesis. I first explore the background literature important in the work completed within this dissertation (Chapter 1). Next, using a …
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Radical cyclization approach to a chemoenzymatic synthesis of morphine
… synthesis of the isoquinoline alkaloid morphine was designed which incorporated the ten-membered silicon-containing epoxide [figure 1], the diene diol [figure 2], and the known oxazolone [figure 3]. See: Figures 1, 2, and 3 Diene diol [figure 2] was isolated in the amount of 200 mg/L …
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Postmortem changes in morphine and ethanol disposition in the rat
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Effects of morphine, d-amphetamine, and food deprivation on temporally organized behavior
Two experiments examined the effects of morphine and d-amphetamine on behavior that was temporally organized under several schedule arrangements. Two body weights were assessed for each experiment. Experiment 1 made use of fixed-interval (FI) schedules, the peak procedure, and a two-key …
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The Interaction of Pain and Morphine on Analgesia, Locomotion, and Cognitive Functioning
… after complete Freund's adjuvant injection and morphine treatment. Whereas pain had little effect on spatial memory, morphine had profound detrimental effects that persisted beyond the analgesic effectiveness of the drug. However, morphine-induced cognitive deficits were absent when morphine was …
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Barriers to morphine use in primary care in the Cape Town metropole
Background Access to oral morphine is an essential element of palliative care services, and a useful indicator of the availability of those services. The South African National Policy Framework and Strategy on Palliative Care 2017- 2022 envisages a system in which palliative care is widely …
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Effects of d -amphetamine and morphine on behavior maintained by fixed -interval schedules
… tested the effects of d-amphetamine and morphine on pigeons' responding during conventional and clocked FI schedules of food reinforcement. The first experiment compared performance between FI 5-min and continuously clocked FI 5-min components of a multiple schedule in which the rate of …
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Locomotor activity does not predict individual differences in morphine self-administration in rats
… individual differences in acquisition of i.v. morphine self-administration (SA) in rats. A secondary goal was to evaluate the relationship between activity and elasticity of demand (reinforcing efficacy) for morphine measured using a behavioral economic approach. Following an initial locomotor …
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Applications of dihydroarenediols to chemoenzymatic synthesis : approaches to total synthesis of morphine alkaloids
… goal, our recent progess toward the synthesis of morphine alkaloids from aromatic precursors. Model substrates were synthesized which allowed investigation into Diels-Alder, radical cascade, and palladium-catalyzed bond-forming reactions as possible routes to the morphine alkaloid skeleton. As a …
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