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Showing 1 to 18 of 18 for “"monoubiquitination"”.
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Investigations into the regulation of histone H2B monoubiquitination
Transkriptionsassoziierte Chromatinmodifikationen spielen eine wichtige Rolle bei der Reglation der Genexpression. So konnte die Mono-Ubiquitinierung des Lysinrestes K120 von Histon H2B (H2Bub1) beispielsweise mit transkriptionell aktiven Genen in Verbindung gebracht werden. Zum einen konnte …
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Non-proteolytic roles of the ubiquitin-proteasome system in memory formation across the lifespan
… brain. Epigenetic modifications, such as histone monoubiquitination and ubiquitin signaling, have emerged as key players in these processes. While monoubiquitination of histone H2B is a well-established regulator of increased gene transcription in memory formation, the role of histone H2A …
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Modulation of Kras Structure and Dynamics By Kras Ubiquitination and Membrane Depolarization
… and the membrane.</p> <p>KRAS undergoes monoubiquitination at two sites, Lys104 and Lys147. We observed that ubiquitin is quite dynamic around KRAS and forms weak non-specific interactions with KRAS. Through these interactions, it is capable of modulating KRAS dynamics to overcome …
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REGULATION OF EUKARYOTIC TRANSCRIPTIONAL ELONGATION AND ASSOCIATED DNA REPAIR
… gene and hence transcriptional elongation is the monoubiquitination of histone H2B at lysine 123. A complex of an E2 conjugase, Rad6p, and an E3 ligase, Bre1p, is essential for this process. Consistent with the role of histone H2B monoubiquitination in promoting the association of RNAPII with the …
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Sex-differences in proteasome-independent roles of the ubiquitin proteasome system in memory formation
… being labeled and a protein can gain one (monoubiquitination) or multiple (polyubiquitination) ubiquitins. The 26S proteasome is the catalytic component of the UPS and is comprised of a 20S catalytic core surrounded by two 19S regulatory caps. Phosphorylation of 19S cap regulatory subunit …
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Modulated Functions of The Fanconi Anemia Core Complex
… and carries out the spatially-defined FANCD2 monoubiquitination reaction to ensure that nucleases for DNA damage processing are enriched at the site of lesion. The deviate functions of different FA core complementation groups imply differential disease biology related to prognosis and …
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Analysis of post-translational modifications of the blue light photoreceptor, phot1, by the CRL3NPH3 ubiquitin ligase complex
… photoreceptor is internalized in the absence of monoubiquitination signal, but recent evidence suggests that the mono/multiubiquitination signal is responsible for targeting the photoreceptor and is necessary for phototropism. We propose that phot-dependent phototropism is modulated in large part …
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TOWARD STRUCTURAL INSIGHTS INTO THE RECOGNITION OF H3K27 TRIMETHYLATION BY CANONICAL PRC1
… Repressive Complex 1 (PRC1) catalyzes the monoubiquitination of histone H2A at lysine 119 (H2AK119ub1) and are classified as canonical (PRC1.2 and PRC1.4) and variant (PRC1.1, PRC1.3 and PRC1.6), which differ in subunit composition, chromatin recruitment and catalytic efficiency. Canonical …
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HISTONE POSTTRANSLATIONAL MODIFICATIONS AND GENE EXPRESSION IN SACCHAROMYCES CEREVISIAE
… H3 acetylation at lysines 9 and 14 (H3K9/14), monoubiquitination of histone H2B at lysine123 (H2BK123) and H3 lysine 4 methylation (H3K4) are among the more studied ones. The importances of these modifications have been further stressed by its connection to various human diseases including …
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Untersuchung und Spezifizierung der molekularen Interaktion von Ubiquitin und Sumo mit dem rekombinanten a1-Glyzinrezeptor
… on SDS-PAGES. It was therefore possible to show monoubiquitination of the GlyR alpha 1-subunit. A special mutation without cytoplasmatic lysines was not ubiquitinated, however was degraded into the same proteolytic pieces specific for ubiquitin mediated endocytosis as the wildtype. This implies …
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Anaplasma phagocytophilum remodels its host cell-derived vacuole into a protective niche by redecorating the vacuolar membrane with select Rab GTPases and bacterial proteins
… activity, and fate of protein substrates. Monoubiquitination directs membrane traffic from the plasma membrane to the endosome and has been shown to promote autophagy. We show that monoubiquitinated proteins decorate the AVM during infection of promyelocytic HL-60 cells, endothelial RF/6A …
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Molecular and epigenetic mechanisms of fear memory
… to target genes during memory formation. Monoubiquitination of histone H2B (H2Bubi) is critical for recruiting H3K4me3 to DNA in a gene-specific manner during memory formation in the hippocampus. Furthermore, there is a great overlap between H3K4me3 and phosphorylation of histone H2A.X at …
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Antiapoptotische Wirkungen des Makrophagen-migrationsinhibierenden Faktors (MIF) auf das Tumorsuppressorprotein p53 bei der ROS-induzierten Apoptose
… the process of ROS induced apoptosis a potential monoubiquitination of MIF was discovered, which seems to disappear under hyperoxic conditions. At present, no function regarding the secretion of MIF can be assigned to this modification. First attempts also resulted in no references that MIF is …
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PARKIN, BLM AND EXO1: INVOLVEMENT IN POST-NER ACTIVITY IN NON-REPLICATING CELLS
… (TLS) polymerases via Rad6-Rad18 mediated monoubiquitination of the Proliferating Cell Nuclear Antigen (PCNA). If this process is impeded, long ssDNA generation and exposure trigger the activation of the DNA damage checkpoint signaling cascade and can potentially lead to the generation of …
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The role of Igf2 methylation and histone ubiquitination in age-related memory decline
… well as in memory formation. Specifically, H2B monoubiquitination at lysine 120 (H2Bubi) has recently been shown to be a major regulator of the epigenome and transcriptome during memory formation, which is proposed to occur through the ability to recruit H3 lysine 4 trimethyl (H3K4me3), another …
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Defining The Functions of Usp22 and Usp44 In Regulation of H2Bub1 Levels
… disorders and cancers. Particularly, Histone H2B monoubiquitination (H2Bub1) is highly associated with gene regulation in both normal cells and diseases. Many deubiquitinases (mainly USPs) are defined to regulate global H2Bub1 levels. However, how these USPs are regulated and how they contribute …
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Structural and Biochemical Investigation of Fanconi Anemia Pathway Activation
DNA interstrand-crosslinks (ICLs) are covalent links between complementary DNA strands that prevent their separation, interfering with fundamental cellular processes such as DNA replication and transcription. Consequently, these DNA lesions are highly toxic and the inability to repair them results …
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Epigenetic Regulation of Replication-Dependent Histone mRNA 3 End Processing
CDK9, eine cyclin-abhängige Ser/Thr-Kinase, phosphoryliert die C-terminale Domäne der größten RNA Polymerase II (RNAPII)-Untereinheit an Serin 2. Diese posttranslationale Modifikation reguliert die Aktivität der RNAPII im Anschluss an die Transkriptionsinitiation. Darüber hinaus wird CDK9 ebenfalls …