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Showing 1 to 1 of 1 for “"monomeric double-strand break mechanism"”.
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DNA hydrolysis and genome editing applications of GIY-YIG family homing endonucleases
… Genomic alterations are most efficient when a double-strand DNA break is introduced at the loci where the modification is desired. Different classes of naturally occurring DNA endonucleases, including homing endonucleases, have therefore been explored as candidates for genome modification …