Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"monogenic diabetes"”.
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Monogenic diabetes in large population settings
… to utilise large population cohorts to analyse monogenic diabetes. This will involve gene discovery searching for novel disease genes and variants, assessing the penetrance and comorbidities risk in carriers of pathogenic monogenic diabetes variants, and studying disease prevalence in the …
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Modeling Monogenic Diabetes Mody3 Using Human Pluripotent Stem Cells
Understanding monogenic diabetes has been challenging due to the lack of human model but also because mouse models do not recapitulate the disease. Here, we use human pluripotent stem cells (ESCs) and CRISPR-CAS9 (Clustered Regularly Interspaced Short Palindromic Repeat)/Cas9) nucleases to …
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The use of human pluripotent stem cells to model HNF1B-associated diabetes
… (HNF1B), result in multisystem disease including diabetes due to beta-cell dysfunction and pancreatic hypoplasia. However, the mechanisms that underlie development of diabetes in HNF1B mutation carriers are still not fully understood due to lack of an appropriate model system. Human induced …