Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"monocyte/macrophage"”.
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Factors governing monocyte-macrophage physiology and function during atherosclerotic cardiovascular disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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Differenziamento macrofagico: gli effetti dei polimeri sintetici
… involved in the inflammatory responses, i.e. monocyte/macrophages. In consideration of what above said, the aim of this study is the comprehension of the in vitro effect of PAI, PVA and PU on three cell lines that represent three different stages of macrophagic differentiation: U937 …
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Human immunodeficiency virus (HIV)-mediated cardiac fibrosis: implication of cellular immunomodulation and cytokine profile alterations
… cell 1 (Th1) and T-helper cell 2 (Th2)), monocyte/macrophage subsets (macrophage type 1 (M1) and macrophage type 2 (M2)) and circulating fibrocyte subsets (CD34+, collagen 1 [COL1+]). We further examined how these immune and profibrotic parameters relate to (i) classical markers of HIV …
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An Infection Model for Examining the Effects of Gender and Diabetic State on Proinflammatory Cytokine Secretion by Phagocytic Cells in Response to Infection with Burkholderia pseudomallei
… pathogenic. This study examines various in vitro monocyte / macrophage infection models used to study innate immune responses to B. pseudomallei. Several monocyte and macrophage models showed little or no significant differences between proinflammatory cytokines secreted in response to infection …
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The role of the P28 multigene family in the pathogenesis of Ehrlichia chaffeensis infection.
… bacterium which parasitizes cells of the monocyte/macrophage lineage in mammals. <i>E. chaffeensis</i> possesses a unique cell wall that lacks LPS and the classical peptidoglycan found in other gram-negative bacteria. <i>Ehrlichia</i> reside inside unique membrane-bound vacuoles in the …
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Runx2 and Vascular Calcification
… of atherosclerosis and polarization of lesional macrophages. Removal of Runx2 did not affect monocyte/macrophage recruitment and atherosclerotic lesion size. Within lesions, we observed a strong shift in macrophage polarization toward an M2 polarization in atherosclerotic aortas. Using a …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… are associated with persistent neuronal damage, monocyte/macrophage activation, chronic inflammation, and oxidative stress. Heme oxygenase-1 (HO-1) is a highly inducible, detoxifying enzyme critical for limiting oxidative stress, inflammation, and cellular injury within the central nervous system …
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Cell tropism of maedi-visna virus
… cells of MVV infection in vivo are cells of the monocyte/macrophage lineage. However, certain MVV strains can infect various other cell types in vitro and by experimental infection in vivo. It has been shown previously that a repeated sequence in the LTR of MVV extends the cell tropism of the …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… in PHH. PHH cultures were positive for monocyte, macrophage, and dendritic cell mRNAs, suggesting that standard PHH cultures contain non-parenchymal cells (NPCs). Immunodepletion of NPCs eliminated expression of immune and anti- inflammatory markers in PHH cultures, which then showed no …
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Characterization of 𝘈𝘵𝘩𝘴𝘲1, an Atherosclerosis Modifier Locus on Mouse Chromosome 4:
… 9p21. Interestingly, mRNA expression analyses in macrophages revealed markedly decreased 𝘊𝘥𝘬𝘯2𝘢 transcript expression in cells derived from congenic mice compared to the controls. 𝘊𝘥𝘬𝘯2𝘢 is a candidate locus associated with the 9p21 locus in humans. The potential role of bone marrow -derived …
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Study of anti-inflammatory functions of HDL in experimental mouse models
… phenotype. Further characterization in RAW 264.7 macrophages in vitro showed that serum and HDL, but not chylomicrons and VLDL (triglyceride-rich lipoproteins; TRL fraction) or the lipid-free protein fraction of Lcat-/- mice, had a reduced capacity to attenuate the LPS-induced TNFα response. …
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Characterisation of the role of mitochondrial dysfunction and meta-inflammation as a shared pathogenic network in gestational diabetes mellitus
… including markers of mitochondrial dysfunction, monocyte/macrophage population frequency, hormones, inflammatory cytokines and insulin signalling transduction. Results Firstly, distinct phenotypes of GDM were confirmed, relating to both insulin-deficient and insulin-resistant pathologies. …
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Small molecule inhibitors against enteric bacterial glycosyltransferases
… pre-incubation with the two compounds in mouse monocyte/macrophage-like cells (RAW264.7), number of Salmonella enterica strain ATCC 14028 which replicated inside RAW264.7 cells greatly reduced 24 h post infection. Results confirmed that 100066N and 102644N can inhibit NleB/SseK activity both in …
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Characterization of Pleiotropic Activities of alpha1-Antitrypsin
… in vitro; b) the role of oxidized AAT on monocyte/macrophage activation both in vitro and in vivo; c) the effects of augmentation therapy on levels of plasma inflammatory markers and the properties of blood neutrophils obtained from a severe AAT-deficient COPD subject; d) the relationship …
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The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
… associated fibroblasts. CCL2 is known to recruit monocyte/macrophage and promotes cancer progression. We previously found that recombinant CCL2 can directly signal to breast cancer cells and promote cell survival and invasion in vitro. In this study, we aimed to determine the functional importance …
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Histopathology of livers and native organs of recipients following genetically-engineered pig-to-baboon liver xenotransplantation
… platelet aggregation, platelet-fibrin thrombi, monocyte/macrophage margination mainly in liver sinusoids, and vascular endothelial cell hypertrophy. Immunohistochemistry showed minimal deposition of IgM, and almost absence of IgG, C3, C4d, C5b-9, and of a cellular infiltrate, suggesting that …
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Unraveling the Role of EphA4 in Immune-Mediated Arteriogenesis After Ischemic Stroke
… PI3K signaling pathway in peripheral-derived monocyte/macrophages (PDM) treated with soluble Tie2-Fc and a PI3K p110α inhibitor. The results from this dissertation show that loss of PDIC-specific EphA4 led to increased collateral remodeling, associated with decreased infarct volume, improved …
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Regulation of cellular glucose metabolism by HIV-1 infection
… CD4+ T cells and terminally differentiated macrophages during the course of HIV-1 pathogenesis. While HIV-1 infection of CD4+ T cells induces G2 arrest and cell death within 2-3 days, HIV-1 infection of macrophages results in longer survival of infected cells and low constitutive viral …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… different dosages in murine bone-marrow-derived macrophages (BMDM). The pro-inflammatory cytokine IL-12 was most strongly induced by intermediate LPS dosages, with very low or high doses inducing less robust IL-12 production. Knockout of the inhibitory TLR4 pathway molecules Lyn or IRAK-M …
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Lipopolysaccharide in marine bathing water; a potential real-time biomarker of bacterial contamination and relevance to human health
The quality of marine bathing water is currently assessed by monitoring the levels of faecal indicator bacteria. Among other drawbacks, results are retrospective using the traditional culture based methods. A rapid method is thus needed as an early warning to bathers for bacterial contamination in …