Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 723 for “"monoclonal"”.
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Genentech: Purification of Monoclonal Antibody
Lucentis, a monoclonal antibody fragment produced in Escherichia coli, is used to treat wet age-related macular degeneration, one of the leading causes of legal blindness. The objective of this thesis is to analyze the process of antibody fragment separation and to purify a solution of "Lucentis …
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Intracellular delivery of rabbit monoclonal antibody
… demand. Recently, an increasing number of rabbit monoclonal antibodies (RabMAbs) have been approved to able to recognize subtle distinctions between the changes of intracellular proteins status. They could be good tools for researchers with the ability to traverse through cell membrane into living …
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Radioimmunotherapy using 186Relabeled humanized monoclonal antibodies.
Contains fulltext : 58759.pdf (Publisher’s version ) (Open Access)
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Cost modeling for monoclonal antibody manufacturing
… manufacturing large molecule products, including monoclonal antibodies, for late stage clinical trials and commercial sales. The BioPharmOps site in Huningue, France is expanding their product line but is also trying to reduce costs; cost pressures are increasing as biotech products become a …
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Production of recombinant monoclonal antibodies against HSET
… of HSET in cancer cells, we produced mouse monoclonal antibodies (mAbs) against HSET using a hybridoma technique and characterized them. Peptide antigens of 12 amino acid (aa)-length, designed from the regions corresponding to N-terminus (1-134th aa) and C-terminus (626-672th aa) that do not …
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Targeting Proteins of Aspergillus fumigatus for Monoclonal Antibody Production
IA is increasingly prevalent and problematic among patients with immunodeficiency. Early diagnosis of IA can be difficult because the symptoms patients display are not specific to fungal infections, and the diagnostic tests currently in use are unreliable. It is well known that the organisms that …
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Radioimmunotargeting of Renal Cell Cancer using Monoclonal Antibody cG250.
Contains fulltext : 58758.pdf (Publisher’s version ) (Open Access)
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Modeling approaches to characterize the disposition of monoclonal antibodies
Monoclonal antibodies (mAbs) are engineered immunoglobulins G (IgG) used for more than 20 years as targeted therapy in oncology, infectious diseases and (auto-)immune disorders. Their protein nature greatly influences their pharmacokinetics (PK), presenting typical linear and non-linear behaviors. …
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Monoclonal antibodies against Neisseria Gonorrhoeae: serotyping and diagnostic applications
… (i) to investigate the value of newly developed monoclonal antibody coagglutination reagents for serotyping gonococci according to Protein I variation between strains; (ii) to determine if these or similar monoclonal antibodies could be used in an immunological method for the non -cultural …
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Monoclonal antibody (mAb) purification by counter current chromatography (CCC)
… extended to the rapid, scalable purification of monoclonal antibodies (mAb) from mammalian cell culture, using aqueous two-phase systems (ATPS) of inorganic salts and polymer. A polyethylene glycol (PEG) and sodium citrate system was found to be the most appropriate by robotic phase system …
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Production of Monoclonal Antibodies for Toxoplasma gondii Lactate Dehydrogenase
… the first of all, hybridoma cell lines producing monoclonal antibodies with high affinity and specificity against T. gondii LDH (TgLDH) were established. Methods: After 6-8 week old BALB/c mice were immunized with synthetic peptides of TgLDH, splenocytes were harvested. To get the monoclonal …
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Structure, Function, and Diversity of Monoclonal Anti-Fluorescyl Antibodies
… in conjunction with hybridoma methodology. Monoclonal anti-fluorescyl IgG antibodies (nine clones) were produced by fusion of BALB/c splenocytes and Sp 2/O-Ag 14 myeloma cells. Analyses of these clones were performed in order to compare structure/function relationships and to determine their …
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Monoclonal Antibody Expression and Novel Purification in Nicotiana benthamiana
… alike have realized the vast potential of monoclonal antibodies to treat diseases ranging from arthritis, immune and infectious diseases to cancer. There are a number of antibodies on the market that constitute a large portion of the biopharmaceutical niche in the drug industry. Blockbuster …
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