Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"monoaminergic"”.
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Monoaminergic Signaling in the Human Brain: New Insights
… and decision-making. However, resolving these monoaminergic signals at physiologically and behaviorally relevant spatiotemporal scales in the human brain have been constrained by limitations of available techniques. Within this dissertation, I employ a machine learning-enhanced voltammetry …
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Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
<p>Activation of monoaminergic receptors is essential to the mechanism by which psychostimulants and antidepressants induce changes in behavior. Although these drugs rapidly increase monoaminergic transmission, they need to be administered for several weeks or months in order to produce …
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Investigation of Monoaminergic Neurotransmitter Systems as a Method to Study Alzheimer's Disease-Related Neurodegeneration
… immunotherapy [8]. The analyses of brainstem monoaminergic (MAergic) systems in the APPSwe/PS1ΔE9 was the first to show that Aβ pathology could induce progressive neurodegeneration in vivo [23]. Subsequent studies expanded on these observations showing degeneration initiating at axon terminals …
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Neuropeptides Amplify and Focus the Monoaminergic Inhibition of Nociception in <i>Caenorhabditis elegans</i>
… for neuropeptides to focus the more widespread monoaminergic activation involved in resetting complex neuronal circuits in all organisms.
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… in order to elucidate the effect of Pb on monoaminergic input into the SOC. In addition, sections were immunolabeled with antibodies to VGLUT1, VGAT and VAChT in order to determine whether Pb exposure alters the glutaminergic, gaba-ergic, or cholinergic systems. Pb exposure caused a …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… in order to elucidate the effect of Pb on monoaminergic input into the SOC. In addition, sections were immunolabeled with antibodies to VGLUT1, VGAT and VAChT in order to determine whether Pb exposure alters the glutaminergic, gaba-ergic, or cholinergic systems. Pb exposure caused a …
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A study of the effects of oxypertine on monoaminergic pathways in rat brain using a new HPLC/ECD method.
A new HPLC/ECD system for the measurement of the biogenic amines and their major metabolites has been developed. It comprises of a two column system, one for the analysis of the biogenic amines and one for the metabolites. The preparation of brain samples for analysis has been made as simple as …
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Where Does it Stem From? - Functional Neuroimaging of Monoaminergic Brainstem Nuclei in Altered States of Consciousness: Translational, Diagnostic and Therapeutic Implications
… nuclei – among them in particular the monoaminergic source nuclei and transmitter systems – are consistently implicated in both pharmacological and pathological perturbations of wakefulness/consciousness. Thus, the dysfunction of these nuclei could underpin human ASCs and network …
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Computational analysis of the response of the monoaminergic neurotransmitter system and stress- and sex-steroid hormone systems to administration of antidepressant drugs
This Dissertation was approved for publication on 2018-11-30 at 15:46.
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The role of serotonergic afferents in receptive field organization and response properties of cells in rat trigeminal subnucleus interpolaris
… afferents to the TBNC. In addition, central monoaminergic neurons have been demonstrated to undergo considerable regeneration or collateral sprouting following direct damage or disruption of their sensory input. These monoaminergic neurons normally modulate the function of their targets. …
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The roles of αCaMKII and Ras-GRF2 in the establishment of drug addiction
… role in the plasticity of the glutamatergic and monoaminergic systems by influencing long-term potentiation (LTP). Transgenic mice were tested through an extensive battery of 3havioural (spontaneous behaviours, consumption and conditioned place Deference) and in vivo neurochemical (in vivo …
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On The Future Of Antidepressant Treatments: Targeting Neurotrophic Factors And Plasticity
… antidepressants suggests that elevation of monoaminergic activity may not be their true mechanism of antidepressant action and brings into question the validity of the monoamine theory. As a result, novel biological targets have been investigated for development of more reliable and …
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ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST
<p>Neurotensin is a neuropeptide that influences monoaminergic neurotransmission in areas of the brain involved in the pathophysiology of depression. The forced swim test is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans …
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Tetrahydroisoquinoline Neurotoxins in Parkinson Disease
… and may be involved in the pathogenesis of monoaminergic cell death.</p> <p>In our studies, we utilize enantiomeric-selective high-performance liquid chromatography with electrochemical detection (HPLC-EC) and liquid chromatography with tandem mass spectroscopy (LC-MS/MS) to determine the …
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Functional organisation of behavioural inhibitory control mechanisms in cortico-basal ganglia circuitry: implications for stimulant use disorder.
… As reported in Chapter 2, systemic modulation of monoaminergic transmission by monoamine oxidase A (MAO-A) inhibitors enhanced reversal learning performance, selectively by decreasing the lose-shift probability, thereby implicating a role for dopamine, serotonin and noradrenaline in facilitating …
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Rapid 3D characterization of whole vertebrate brain at cellular resolution
… The analysis successfully detects both monoaminergic diencephalic phenotypes, which have been extensively discussed in the literature, and novel telencephalic phenotypes that were previously overlooked. The telencephalic phenotypes, which include glutamatergic defects in the pallium (the …
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The Effect of Organophosphate Exposure on Neocortical, Hippocampal and Striatal Monoamines: A Potential Substrate for Chronic Psychiatric, Cognitive and Motor Dysfunction
… (CPS), may contribute to the types of forebrain monoaminergic alterations associated with psychiatric, cognitive and motor dysfunction. Increased synaptic ACh, resulting from CPS-induced AChE inhibition, may alter the synthesis or release of monoamines through prolonged action of ACh on …
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Serotonergic Circuits Mediating Stress Potentiation of Addiction Risk
… (Dyn) activates kappa opioid receptors (KOR) in monoaminergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. We found that conditional deletion of KOR from Slc6a4 (SERT)-expressing neurons blocked stress-induced …
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An examination of the impact of dietary lipids on behaviour and neurochemistry
… that early-life stress induces changes to the monoaminergic and immune systems as well as altered neuroendocrine response to stressors later in life. In addition, we found that early-life stress alters the gut microbiota in adulthood. These data demonstrate that n-3 PUFAs can attenuate …
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