Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"monoamine oxidase B"”.
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Mechanistic Studies on the Monoamine Oxidase B Catalyzed Oxidation of 1,4-Disubstituted Tetrahydropyridine Derivatives
The flavin-containing monoamine oxidases (MAO) A and B catalyze the oxidative deamination of primary and secondary amines. The overall process involves a two electron oxidation of the amine to the iminium with concomitantreduction of the flavin. Based on extensive studies with a variety of chemical …
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Synthesis and biological evaluation of novel MPTP analogs as potential monoamine oxidase B inhibitors
… the only known cyclic tertiary amines with good monoamine oxidase substrate properties. In addition to its substrate properties, MPTP is a weak mechanism-based inactivator of monoamine oxidase-B (MAO-B). In an attempt to exploit the special interactions between this cyclic tertiary allylamine and …
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Structure-based approaches applied to the study of pharmaceutical relevant targets
… our attention on Reverse Transcriptase of HIV-1, Monoamine oxidase B and VP35 of Ebola virus. The last chapter is dedicated to the validation of covalent docking performed with Autodock.
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Synthesis and MAO activity of a series of benzimidazolyl and indazolyl prodrugs
… with the neurodegeneration seen in PD is monoamine oxidase-B (MAO-B). Several inhibitors of this enzyme have resulted in neuroprotection in the mouse model of PD. One such compound is 7-nitroindazole (1). This thesis describes the synthesis and MAO activity of several indazolyl and …
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Quantitative structure activity relationships of monoamine oxidase catalyzed oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs
… oxidation catalyzed by monoamine oxidases A and B were performed to elucidate active site substrate conformation and oxidation mechanisms. Plotting experimental kinetic activity against molecular properties obtained by experiment and by computational chemistry methods …
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Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier
… neurodegeneration. Since 7-NI also inhibits the monoamine oxidase-B (MAO-B) catalyzed bioactivation of MPTP, the role of nNOS inhibition as a mediator of 7-NI's neuroprotective properties have been challenged. In order to examine in greater detail the neuroprotective effects of indazolyl …
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Potential Prodrugs of the Neuronal Nitric Oxide Synthase and Monoamine Oxidase Inhibitor 7-Nitroindazole and Structurally Related Compounds
… form of nitric oxide synthase (nNOS) and monoamine oxidase B (MAO-B), have been linked to neurodegenerative pathways leading to PD. Several MAO-B and nNOS inhibitors have been evaluated for their neuroprotective properties in the mouse model of neurodegeneration which employs the …
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Synthesis and mechanistic studies on the monoamine oxidase (MAO) catalyzed oxidation of 1,4-disubstituted-1,2,3,6-tetrahydropyridines
… in a reaction catalyzed by the flavoenzyme monoamine oxidase B (MAO-B) to form the corresponding dihydropyridinium (MPDP+) subsequently pyridinium (MPP+) metabolites. As part of our ongoing studies to characterize the structural features responsible for this unexpected biotransformation, we …
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Synthetic and metabolic studies on centrally acting amines
… and an N-methyl group are likely to be good monoamine oxidase B substrates. The design and synthesis of potential prodrugs based on this enzyme-substrate selectivity has been pursued with model compounds.
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Practical Applications of Molecular Modeling Pertaining to Oxidative Damage and Disease
… the mode of inhibitor binding to the enzyme monoamine oxidase B, the active site mechanism of that same enzyme, the dynamics of the unstructured p53 C-terminal domain in complex with globular, structured proteins, the process of the viral protein B2 unbinding from double-stranded RNA, and a …
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Studies on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and analogs
… in a reaction catalyzed by flavin containing monoamine oxidase B (MAO B) to yield the dihydropyridinium species MPDP+ which undergoes further oxidation to the ultimate toxin, the I-methyl-4-phenylpyridinium species MPP+. The research summarized in this thesis describes a potential model …
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Phytochemical Investigation of Psychoactive Medicinal Plants for the Treatment of Neurological Disorders
… that combination of dopaminergic drugs with monoamine oxidase B (MAO-B) inhibitors, anticholinergics, catechol-O-methyl transferase inhibitors, and other non-dopaminergic drugs can better alleviate levodopa-induced motor complications along with better control of motor symptoms. MAO-B …
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Oxidation of Tetrahydropyridines by MAO B Biomimetics: Mechanistic Studies
… However, its mechanism of oxidation by monoamine oxidase B (MAO B) has been debated for just as long. Proponents of the single electron transfer (SET) pathway of oxidation faced severe critiques in that the hypothesized radical intermediates arising from the SET pathway were never …
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Monoamine Oxidase and Sensory Gating: Psychophysiological Vulnerabilities among Teenage Smokers
… focused on the role of the variable of monoamine oxidase-B (MAO-B) in the correlations among sensory gating, MAO and other cognitive and personality measures. All smokers were divided into high and low MAO groups first. Comparison analyses were conducted between them. The high MAO group …
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Dopaminergic Genetic Contributions to Obesity in Kidney Transplant Recipients
… gene (COMT) SNPs rs4680 and rs4818, monoamine oxidase A gene (MAOA) VNTR, monoamine oxidase B gene (MAOB) SNP rs1799836, and dopamine active transporter gene (SLC6A3/DAT1) VNTR. Genotypes were analyzed using dose dependent and risk allele approaches, and those variants with p≤0.20 …