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Showing 1 to 20 of 115 for “"monoamine"”.
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Monoamine oxidase in neuronal cell death
Monoamine oxidase (MAO) is an oxidative enzyme that deaminates a variety of amine substrates, including the neurotransmitter dopamine. The enzymatic reaction requires molecular oxygen and produces hydrogen peroxide as a by-product. MAO is localised in the outer mitochondrial membrane and exists as …
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Studies on monoamine oxidase in avian brain
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Developmental Monoamine Signaling Impacts Adult Affective and Aggressive Behaviors
… serotonin (5-HT) transporter (5-HTT) and monoamine oxidase A (MAOA) blockade. Pharmacologic MAOA or 5-HTT blockade in adulthood has antidepressant and anxiolytic efficacy. Yet, genetically conferred MAOA or 5-HTT hypo-activity is associated with altered aggression and increased …
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Determinants of Abuse-Related Effects of Monoamine Releasers in Rats
Monoamine releasers constitute a class of compounds that promote release of dopamine, serotonin, and/or norepinephrine. These compounds have a range of different uses in the medical setting, including treatment of attention deficit hyperactivity disorder, narcolepsy, and obesity. A major limitation …
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Monoamine Oxidase and Sensory Gating: Psychophysiological Vulnerabilities among Teenage Smokers
… focused on the role of the variable of monoamine oxidase-B (MAO-B) in the correlations among sensory gating, MAO and other cognitive and personality measures. All smokers were divided into high and low MAO groups first. Comparison analyses were conducted between them. The high MAO group …
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Design, synthesis, and evaluation of rigid probes for the monoamine transporters.
… and evaluation of rigid probes for the monoamine transporters.
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Some Studies on the Purification and the Properties of Monoamine Oxidase
Attempts were made to purify rat liver mitochondrial MAO in a single step by affinity chromatography. Except for tryptamine and serotonin-Sepharose, which irreversibly bound the enzyme, most adsorbents bound little if any of the enzyme. This was true for both detergent (triton X-100 and digitonin) …
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MUTATION OF THE VESICULAR MONOAMINE TRANSPORTER-1 GENE ALTERS ITS PROTEIN PRODUCT
The vesicular monoamine transporter 1 (VMAT1) is essential for storage of monoamines, such as epinephrine and serotonin, in secretory vesicles of neuroendocrine cells. Recently the VMAT1 protein was detected in human and mouse brain, and mutations of the VMAT1 gene at single DNA nucleotides (single …
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Characterization of a novel interaction between presenilin-1 and monoamine oxidase-A
The enzyme monoamine oxidase (MAO) is linked to mental disorders such as depression and neurodegenerative diseases. Our laboratory has recently demonstrated that increases in calcium (Ca²⁺) can enhance MAO activity and that this might contribute to Alzheimer disease (AD). AD has been linked to …
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Structural Determinants of Post-transcriptional Protein Regulation as Modulators of Monoamine Signaling
<p>Monoamines were first discovered at the end of the 19th century when William Bates identified epinephrine (EPI) and noted its hemostatic effects. During the 20th century, norepinephrine (NE), dopamine (DA), and serotonin (5HT) were discovered in both the periphery and the brain. Due, in part, to …
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Effects of Alterations in Monoamine Levels on Conditioned Taste Aversions in the Rat.
… for the production of pretreatment effects of monoamine uptake inhibitors.
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Flavin Amine Oxidases from the Monoamine Oxidase Structural Family Utilize a Hydride Transfer Mechanism
The amine oxidase family of enzymes has been the center of numerous mechanistic studies because of the medical relevance of the reactions they catalyze. This study describes transient and steady-state kinetic analyses of two flavin amine oxidases, mouse polyamine oxidase (PAO) and human lysine …
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Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission
Gastrointestinal peptides like insulin and glucagon-like peptide are not only essential metabolic hormones but can also modulate important brain function, unrelated to feeding behaviour and glucose homeostasis. Different evidence suggests that these peptides, as well as synthetic insulin …
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In vitro release of endogenous monoamine and amino acid transmitters from rat brain synaptosomes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Steroid and monoamine dependent modulation of luteinizing hormone releasing hormone in the ovariectomized rat
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Role Of Sertonin And Vesicular Monoamine Transporters In The Adverse Responses To Methylenedioxymethamphetamine
… in nature. MDMA initially causes synaptic monoamine release, primarily of serotonin (5-HT), producing hyperthermia and hyperactivity (5-HT syndrome). Conversely, the long-term effects of MDMA manifest as a prolonged depletion in 5-HT, and structural damage to serotonergic nerve terminals. …
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A Pharmacologic Study of Anticholinergic and Monoamine Oxidase Inhibitor Drugs in Dogs and Swine
Made available in DSpace on 2014-12-05T22:04:00Z (GMT). No. of bitstreams: 1 6100150.pdf: 4473299 bytes, checksum: bee3c7912623d19262106e6d53807649 (MD5) Previous issue date: 1960
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Mechanistic Studies on the Monoamine Oxidase B Catalyzed Oxidation of 1,4-Disubstituted Tetrahydropyridine Derivatives
The flavin-containing monoamine oxidases (MAO) A and B catalyze the oxidative deamination of primary and secondary amines. The overall process involves a two electron oxidation of the amine to the iminium with concomitantreduction of the flavin. Based on extensive studies with a variety of chemical …
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Synthesis and biological evaluation of novel MPTP analogs as potential monoamine oxidase B inhibitors
… the only known cyclic tertiary amines with good monoamine oxidase substrate properties. In addition to its substrate properties, MPTP is a weak mechanism-based inactivator of monoamine oxidase-B (MAO-B). In an attempt to exploit the special interactions between this cyclic tertiary allylamine and …
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