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Showing 1 to 3 of 3 for “"monastrol"”.
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Small-Molecule Control of Kinesin-5 Proteins
… Kinesin-5 motors. Such compounds, including monastrol (the first Kinesin-5 inhibitor identified), have been employed to study Kinesin-5 activity. A thorough understanding of Kinesin-5 function, combined with the ability to specifically target these proteins with small molecules, may provide …
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Using Chemical Probes to Examine Cellular Activities
… or affected microtubules (nocodazole, taxol, or monastrol), I quantified spastin dynamics during anaphase. Spastin foci accumulated on the periphery of chromosomes and were similar on the spindle pole-facing and midzone-facing sides of chromosomes. However, foci that colocalized with microtubules …
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Diseño y caracterización de inhibidores de la fascina para el bloqueo de la invasión y la metástasis en cáncer colorrectal.
… la imipramina (IMIP), el raltegravir (RAL) y el monastrol (MON). Previamente, el grupo del Dr. HY Huang descubrió el compuesto G2 mediante screening farmacológico y lo caracterizó como un inhibidor de la fascina capaz de bloquear la migración celular, la invasión y la metástasis en cáncer de …