Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 4985 for “"molecule"”.
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Modelling of molecule-inside-dipole complexes: through- vs. around-molecule ion transfer
… and nonpolar (Cyclooctane) molecules with the Li-F ion pair, having potential applications in light-matter interactions, transmembrane ion-pair transport, and energy storage. Structures and stabilities, charge distributions, dipole moments, and infrared intensity spectra, are …
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A small molecule synthesizer
… many advances over the last two centuries, small molecule synthesis remains a relatively complex, unsystematized, and time-intensive process practiced almost exclusively by highly trained specialists. Collectively, these limitations represent a major bottleneck in the efforts to study, understand, …
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Laser-assisted single-molecule refolding
… have developed a new technique combining single-molecule FRET detection with laser induced temperature jump. We have calibrated the magnitude of the temperature jump with 1˚C accuracy using gold micro-size sensor. The accuracy of temperature calibration was confirmed by close agreement between …
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Understanding small molecule-protein interactions
The binding of small molecules to a protein is among the most important phenomena in the chemistry of life; the activity and functionality of many proteins depend critically on binding small molecules. A deep understanding of protein-small molecule interactions and the interplay between ligation …
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Small Molecule Inhibitors of HPV16 E6
… between HPV E6 and its partners using small molecules had the potential to re-sensitize HPV+ cells to apoptosis. To test this prediction, we screened libraries of small molecules for candidates that could block E6/caspase 8 binding, and identified several candidates from different chemical …
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New routes to single molecule magnets
… particular interest for the generation of single molecule magnet (SMM) behaviour. The product family includes a Co4 SMM cluster, a Co6 SMM cluster and a 3D network of linked SMM units. A new route to the erinaceous Co6 cluster crystals is reported, which allows further investigation of the …
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Signal Processing In Single Molecule Studies
… techniques used in investigating single molecule kinetics and interactions. The first chapter provides an overview of signals and systems pertaining to single molecule studies. It discusses the need for signal processing, and gives a summary of current single molecule techniques. The …
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Small Molecule Binding to Disordered Proteins
… arisen from a lack of understanding of how small molecules bind disordered proteins. In this thesis, I combine biophysical experiments and computational ensemble determination techniques (metadynamic metainference) to characterise small molecule interactions with disordered proteins. After an …
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Molecule-Based Magnets Constructed From Hexacyanometalates
Improved preparations are given for several first-row transition metal trifluoromethanesulfonate (OTf) and p-toluenesulfonate (OTs) salts: M(OTf)x, where M = VII, VIII, CrII, MnII, CoII, NiII , and Cs, and [M(OH2)n][OTs]x, where M = TiIII, VIII, VIVO, Cr II, CrIII, MnII, FeII, CoII, NiII, and Cs. …
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Magnetization dynamics of single molecule magnets
Made available in DSpace on 2014-09-16T17:25:53Z (GMT). No. of bitstreams: 2 Yun_Liu.pdf: 2936489 bytes, checksum: 870b4bdf8c282c749cf14f4925088600 (MD5) license.txt: 4056 bytes, checksum: c0d6bd6324ecaf18c5d2647589f9beff (MD5)
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Single molecule investigation of antiviral signaling
… to antagonize viral invasion. We utilized single-molecule fluorescence in situ hybridization (smFISH) to study viral and antiviral gene expression in individual cells. We precisely quantified kinetics of mRNA expression of RIG-I with respect to IFN- in cells upon infection with Sendai virus …
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Single molecule studies of helicase mechanisms
… resolutions, as well as the ability to look at molecules one at a time instead of in an ensemble, have been shown to be helpful in elucidating the specific actions in many biological systems. Single molecule FRET (smFRET) microscopy provides these abilities with a distance scale of 2-8 nm, 8 ms …
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Molecule surface triangulation from alpha shapes
… Common geometric models for proteins and other molecules are the space filling diagram, the solvent accessible surface and the molecular surface. In this thesis we present a new approach to triangulating the surface of a molecule under the three models, which is fast, robust, and results in …
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Expanding automated modular small molecule synthesis
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Small molecule inhibitors of parasitic enzymes
The work presented in this thesis is threefold:-(i) development of potential novel inhibitors of cysteine proteases from the causative agents of Malaria, African sleeping sickness and Chagas disease, (ii) development of potential new and novel anti-trypanosomal inhibitors of trypanosome alternative …
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Small molecule inhibitors against enteric bacterial glycosyltransferases
Enteric bacterial pathogens are the major sources of foodborne diseases. Infection caused by these pathogens leads to gastroenteritis thus of great threat to public health. Pathogenic bacteria evolved to develop various secretion systems to deliver virulence proteins termed ‘effectors’. These …
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Single Molecule Study of Polymer-Surfactant Interactions
… fractions viz fast diffusing fraction of dye molecule along with the larger aggregates are observed in between the critical aggregation concentration (CAC) and end of aggregation (EOA). FCS is used to follow the dynamics of single aggregates of the different populations. At very high …
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