Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"molecular transporter"”.
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Amphiphilic Cyclic Cell-Penetrating Peptides Containing Tryptophan and Arginine as Anticancer Agents and Drug Delivery System
… arginine (R) were synthesized and evaluated as a molecular transporter and for their ability to deliver doxorubicin (Dox) and large molecular weight molecules, such as siRNA and proteins. We prepared a cyclic peptide containing alternative tryptophan (W) and arginine (R) residues and a lysine …
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Cyclic and Linear Cell-Penetarating Peptides Composed of Tryptophan (WW) and Arginine (RR) Residues as Molecular Transporters
… the corresponding linear peptides and can act as molecular transporters. Herein we report the synthesis of linear and cyclic peptides containing alternate WW and RR residues and the evaluation of their cytotoxicity, cellular uptake, and confocal microscopy of peptides compared to [WR]<sub>5</sub>. …
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Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Tools and Antimicrobial Agents
… [DipR]<sub>5</sub> can act as a molecular transporter of several compounds including the cell-impermeable phosphopeptide and siRNA specifically.</p> <p>The antibacterial activities of peptides were evaluated against pathogens. The minimum inhibitory concentrations (MIC) of …
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Amphipathic Hybrid Cyclic-Linear Peptides as a Drug Delivery System
… have been previously identified as molecular transporter Cell Penetrating Peptide (CPP) and antimicrobial agents, respectively. These peptides consisted of alternating and non-alternating arginine (R) as positively charged residues and tryptophan (W) as hydrophobic residues. Herein …
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Cyclic and Linear Peptides Containing Tryptophan and Arginine Residues as Cell-Penetrating Peptides and Antifungal Agents
… The peptides were examined as potential molecular transporters and cell-penetrating peptides (CPPs), and their efficiency in delivering cell-impermeable compounds was compared with [WR]5. The peptides showed no significant cytotoxicity in different cell lines (MDA-MB-231, SK-OV-3, and …
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Hybrid Cyclic-Linear Cell-Penetrating Peptides Containing Alternative Positive and Hydrophobic Residues as Molecular Transporters
… (X=1-5) to compare their molecular transporter efficiency. The peptides were synthesized through Fmoc solid-phase peptide synthesis. Final compounds were purified by a reversed-phase HPLC (High Performance Liquid Chromatography). The chemical structures of the final …
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Design and Evaluation of Cyclic Peptide-Epirubicin Conjugate for Enhanced Anticancer Activity and Reduced Myocardial Toxicity
<p>Despite the introduction of molecularly targeted drugs, chemotherapy remains at the frontline of cancer therapy. However, multi-drug resistance and the non-specific distribution of anticancer drugs to healthy cells pose challenges that limit the clinical application of these drugs.</p> …