Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"molecular therapies"”.
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Controlling Curvature and Stiffness in Fibrous Environments Uncovers Force-Driven Processes and Phenotypes
… when in the presence of clinically relevant molecular therapies. Overall, we investigated cancer biology through stiffness gradients, geometric influence through biophysics on myoblasts, and immune cell migration forces as a strong indicator of cell behavior.
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
… knowledge may lead to the development of novel molecular diagnostic approaches, as well as innovative drug delivery modalities for small RNA-targeted therapy. My research resulted in a) the establishment of new methods and approaches to the study of exosomes/EVs, as well as comparative …
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Chondrocyte Regulation by IL-I and IGF-I: Interconnection Between Anabolic and Catabolic Factors
… mechanisms. These results have implications for molecular therapies (e.g., gene transfer) directed at reversing osteoarthritic cartilage deterioration. The presented research concerns not only cartilage biology but also tissue engineering strategies for cartilage repair. Alginate hydrogel culture …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… debilitating side effects associated with most therapies. There is therefore a need to improve current breast cancer therapy and/or to develop new and efficacious therapeutic drugs. One approach to addressing this has been to elucidate the molecular mechanism(s) underpinning this disease to …
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Preclinical Models to Identify Molecular Drivers of Metastasis in Paediatric Musculoskeletal Cancer
… a robust experimental pipeline to study the molecular drivers of metastasis, applicable across multiple musculoskeletal tumors. Here, the experimental model has been applied to the molecular mechanics of Ewing’s sarcoma as well as human and canine osteosarcoma. An established murine …
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The role of Ubiquitin ligases Nedd4-1 and Nedd4-2 in the brain and their crosstalk with alpha-synuclein and other dementia-related proteins
… altered to exhibit PD-and DLB-like traits at a molecular level, allows the study of which proteins may be involved in the mechanisms of PD and DLB, and may alter α-synuclein accumulation and aggregation.<br/>Neural precursor cell-expressed developmentally derived 4 (Nedd4) is a family of …
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Recognition of hepatitis B epitopes by T cell receptors and T cell receptor-like antibodies
… TCRs with improved activities in adoptive T cell therapies, which are known to benefit from such intermediate affinity TCRs. The molecular probes available to specifically target peptide-major histocompatibility complexes are relatively uncommon and thus the capacity to study pMHC distribution and …