Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"molecular switches"”.
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Synthesis and applications of new biomimetic molecular switches
… de dos nuevas familias de interruptores moleculares, las cuales se basan respectivamente en el cromóforo de la base de Schiff protonada del retinal (benziliden-pirrolinas) y el cromóforo de la proteína verde fluorescente (alquiliden-oxazolonas). Tras una breve introducción (Capítulo 1), …
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Design, Synthesis, Photochemical and Biological Evaluation of Novel Photoactive Molecular Switches
… mainly focused on the study of new families of molecular switches based on E/Z isomerism. Specifically, it is evaluated their photophysical and photochemical properties, and how they can be tuned by slight modifications in their structure. Moreover, the off/on photoactivation of the cytotoxicity …
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Quantum mechanical study of molecular switches : electronic structure, kinetics and dynamical aspects
Molecular photoswitches are attracting much attention lately mostly because of their possible applications in nano technology, and their role in biology. One of the widely studied representatives of photochromic molecules is azobenzene (AB). With light, by a static electric field, or with tunneling …
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Probing the Ultrafast Dynamics of Higher-Lying Excited States of Molecular Switches with Femtosecond Stimulated Raman Spectroscopy
… dynamics and product yield of many photoactive molecular systems. However, due to their short lifetimes and high density of states, the initial dynamics and molecular motions within the upper states is less understood. In this dissertation, the higher-lying excited states of photochemical …
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Synthesis and conformational study of trans-2-aminocyclohexanol-based pH-triggered molecular switches and their application in gene delivery
… (TACH) is a promising model for pH-triggerable molecular switches with a variety of potential applications. In particular, such a switch, when incorporated into cationic liposomes, provides a novel design of the pH-sensitive helper lipids for gene delivery. Protonation of TACH molecules results …
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FUNCTIONAL REDOX-ACTIVE MOLECULAR TUNNEL JUNCTIONS
Molecular electronics, which use single molecules or self-assembled monolayers as active electrical elements, are complementary to semiconductor-based electronics with the ultimate goal of reducing the footprint or energy consumption of the electronic devices or uncovering new functionalities for …
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Cell polarity under extreme morphological conditions
… localisation of proteins that act as diffusive molecular switches. Since the localisation of these proteins depends on their reactive and diffusive properties, cell size and growth may alter polarity induced by localisation. My work contributes extensive analyses of an established protein …
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Molecular Devices: Brakes, Rotors, Sensors, and Balances and the Non-Covalent Interactions That Power Them
… at the Bottom' predicted the advent of nano- and molecular-scale machines. Only recently has Feynman's vision begun to be realized with the syntheses of molecular devices that convert chemical or kinetic energy into controlled mechanical molecular motions. In this thesis, several types of …
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Structural and Spectroscopic Characterization of Modular Photoreceptors
… modularity and reversibility make them promising molecular switches in optogenetics and other biomedical applications. In this dissertation, I talk about how I applied crystallography, spectroscopy, and biochemical methods to investigate a few distinct CBCRs regarding the molecular mechanisms of …
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Photoresolvable compounds: Towards a chiroptical-liquid crystalline switch
… effort in bringing this miniaturization to the molecular level, i.e. the design of molecular switches. The possibility of using photons to address a switch at an specific site in a volume has motivated research in photoresponsive compounds. An interesting family of photoresponsive compounds are …
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Characterisation of the expression profile and endothelial function of Rho GTPase RhoJ
Rho GTPases are molecular switches that regulate many aspects of cell physiology. A number of Rho GTPases are essential for the formation of new vessels from pre-existing ones, a process known as angiogenesis. RhoJ/TCL belongs to the Cdc42 subfamily of Rho GTPases. Previous bioinformatic and …
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Synthesis and Characterisation of Photoresponsive Azobenzene-Biomolecule Conjugates
… around the design, synthesis and application of molecular switches with a focus on the field of azobenzene switches, their isomerisation mechanisms and their value as control units on biological molecules. The introductory chapter is followed three synthesis chapters reporting on the application …
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Structural and Biochemical Characterisation of the HR1 domains of the Protein Kinase C-related kinase family
The Rho family of small GTPases act as molecular switches in the cell and are involved in signalling pathways implicated in cytoskeletal organisation. To mediate their effects, they interact with downstream effectors. The protein kinase C-related kinase (PRK) family of serine/threonine kinases …
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Photophysical transformations in molecules studied by ultrafast multi-pulse spectroscopy /
… which are considered as the fastest molecular switches, are investigated. It was found that the current understanding must be redefined, as these compounds do not actually undergo ring-opening in acetonitrile solutions, therefore they are not “switches” by definition. Instead, it is …
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Molekulių fotofizikinių virsmų tyrimas ultrasparčiosios daugiaimpulsės spektroskopijos metodais /
… which are considered as the fastest molecular switches, are investigated. It was found that the current understanding must be redefined, as these compounds do not actually undergo ring-opening in acetonitrile solutions, therefore they are not “switches” by definition. Instead, it is …
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Molecular Optoelectronics in Plasmonic Nanocavities
… exploration of light-matter interactions at the molecular level. This thesis investigates the integration of molecules with plasmonic nanostructures to develop novel optoelectronic devices and gain deeper insights into nanoscale phenomena. The research focuses on two primary nanostructures: the …
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The Role of Rac and Filamin A in Osteoclast Function and Osteoclast Heterogeneity
… by Rho GTPases. Rho GTPases function as molecular switches that regulate the actin cytoskeleton in osteoclasts and many other cell types. A Rac GTPase validation experiment was used to prove that osteoclast function is best characterized through three-dimensional (3-D) volumetric analysis …
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Conserved Residues in Murine Papillomavirus E2 Regulate the Viral Life Cycle
… modifications on conserved residues in E2 act as molecular switches that regulate E2 activity throughout the cellular and viral life cycle.
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Analysing First Passage Time Distributions of Large Ill-Conditioned Energy Landscapes
… Multifunnel landscapes are associated with molecular switches and multifunctional materials, and are expected to exhibit multiple relaxation time scales. Energy landscapes, consisting of local minima connected by transition states, can be represented by a kinetic transition network. Each …
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Lysosome biogenesis during osteoclastogenesis
… biosynthetic pathways. Nevertheless the exact molecular mechanisms responsible for sorting of the biosynthetic imput involved in the lysosome biogenesis is still a matter of debate. Because osteoclast precursors do not secrete their lysosomal enzymes and osteoclasts do, the observation of …
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