Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"molecular switch"”.
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Structural and functional analysis of a phospho-dependent molecular switch: Rv1827 from Mycobacterium tuberculosis
… from Mycobacterium tuberculosis, a complete molecular description of an FHA-mediated Ser/Thr protein kinase signalling process is derived. First, binding of the FHA domain to each of three metabolic enzyme complexes regulates their catalytic activities but does not require priming …
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Mapping the Neural Circuits That Modulates the Molecular Switch Between Alternative Interval Timing Behaviours in Drosophila Melanogaster
Neuropeptides are central modulators of many functions including male-specific mating behaviours. Understanding how these chemical messengers modulate the neural substrates are still not well understood but remains important for biological research. In Drosophila melanogaster, two well-defined …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… colonies. Currently, the mechanism of how TGF-β switches its role from tumor suppressor to promoter still remains elusive. Here we identify that overexpression of 14-3-3ζ inhibits TGF-β’s cell cytostatic program through destabilizing p53 in non-transformed human mammary epithelial cells. …
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Molecular and Biochemical Analyses of a Three-Subunit Euryarchaeal Clamp Loader Complex
… manner. The critical clamp loader acts as molecular switch from distributive to processive DNA synthesis. Here, we describe a novel form of clamp loader from the euryarchaeon Methanosarcina acetivorans (Mac). The M. acetivorans clamp loader comprises two similar small subunits (MacRFCS1 and …
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Axon guidance in the zebrafish visual system: Analysis of Esrom Mutant
… These data suggest that esrom might act as a molecular switch to integrate signal transduction events in axons.
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Photocontrol of Antibacterial Activity
… molecules that incorporate in their structure a molecular switch. The photoactive moiety can undergo an isomerization process that induces changes in the molecule properties like dipole moment, geometry, or electronics. These changes can result in isomers with different biological activity. Thus, …
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Responsive molecules: 1. Redox-responsive quadruple hydrogen bonding unit 2. Crosslinked dendronized polyols for brighter and more stable dyes 3. Photoresponsive proton gate for cross-membrane transfer
… can be introduced or tuned in different molecular systems thus providing desirable control over material properties. In Chapter 2, we designed a new quadruple hydrogen-bonding module (eDAN). The binding affinity of this molecule towards its partner (DeUG) was specifically controlled by …
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Biomimetic sensor for in-vivo applications
… development of sensitive specific devices (e.g., molecular sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic …
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Regulation of Organelle Transport by Myosin v in the Cell Cycle
… residue, Ser1650, was found to comprise the molecular switch for motor release and, therefore, downregulates myosin V during mitosis. In addition, CaMKII was found to specifically phosphorylate Ser1650 in vitro and also regulated motor binding to the organelle. This is the first demonstration …
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Apolipoprotein E4 and SirT1 Interaction in Alzheimer’s Disease
… retraction, and has been shown to function as a molecular switch with two separate cleavage patterns. Cleavage at the β-, γ-, and caspase sites results in the production of four neurotoxic, pro-apoptotic, pro-AD peptides: sAPPβ, Aβ, Jcasp, and C31. In contrast, anti-AD cleavage at the α-site …
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Mechanisms of Synapse Formation and Synaptic Plasticity
… than time-dependent manner. I show that the molecular switch underlying this form of potentiation is calcium/calmodulin kinase II (CaMKII). Taken together, these studies demonstrate both intrinsic and extrinsic mechanisms of synapse formation and identify a novel role for CaMKII in a …
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Hedgehog Signaling Plays a Conserved Role in Inhibiting Fat Formation
… studies showed that Hh signaling might act as a molecular switch, likely mediated by anti-adipogenic transcrition factors such as GATA2, to divert preadipocytes as well as multipotent mesenchymal prescursors away from adipogenesis to osteogenesis. My study on the function of Hh signaling in fat …
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Identification of altered Ras signaling and intermediate filament hyperphosphorylation in giant axonal neuropathy
… the Ras signaling protein, which functions as a molecular switch to regulate the phosphorylation and subsequent organization of IFs. The connection between these pathways led us to propose that Giga regulates IF phosphorylation and structure by modulating Ras signaling through the degradation of …
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Applications for imidazophenanthridine-based heterocycles
… states formed the basis of a redox “lockable” molecular switch that could be useful for molecular level information processing and data storage. The pH dependent cyclisation between the TIP and AEP forms was also investigated as a targeting mechanism for potential intercalating antitumour …
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Structural and Functional Studies of Escherichia coli Kinases and Phosphatases
… underlying its bifunctionality and its molecular switch. Through structural comparison and, particularly, functional characterization, we revealed that YjjX is a novel ITPase/XTPase responsible for the removal of non-canonical nucleotides from the cell during oxidative stress in …
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Identification of Substrates and Pathways Regulated by WNK1
… interactors for a better understanding of the molecular pathways served by WNK kinases. Yeast two-hybrid screening was performed to identify the binding partners of WNK1 and yielded genuine interactors including synaptotagmin (Syt) isoforms, Smad2, and dynein light chain (LC8/PIN). WNK1, not …
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Fliposomes: pH-sensitive liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles as conformational switches for the liposome mebrane
<p>As a promising pH-triggerable molecular switch, trans -2-aminocyclohexanol (TACH) has a variety of applications. By introducing two hydrocarbon tails, multiple TACH-based lipids (flipids) have been designed and studied that are able to perform a drastic conformational flip upon protonation, …
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The Role of Linker 2 (L2) Region in RhTRIM5α Assembly and HIV-1 Restriction
… dependent manner and possibly acts as a molecular switch in the assembly of rhTRIM5alpha.</p>
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From Flies to Mice: Drosophila as a Model System to Study Fat Biology
… upstream of PPARgamma, potentially acting as a molecular switch diverting preadipocytes and mesenchymal prescursors away from adipogenesis and towards osteogenesis. In another study, I investigated the role of Adipose, an evolutionarily conserved gene isolated from naturally occurring obese …
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