Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"molecular subtypes"”.
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Breast cancer incidence and survival trends by molecular subtypes in Scotland
… progression. BC is heterogeneous, with multiple subtypes defined by molecular markers, such as the oestrogen receptor (ER), that have different aetiology, targeted treatments and prognosis, yet standard reporting of incidence and mortality rates is not usually done using tumour marker data. The …
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Non-Coding Rnas Identify The Intrinsic Molecular Subtypes of Muscle-Invasive Bladder Cancer
<p><strong>NON-CODING RNAS IDENTIFY THE INTRINSIC MOLECULAR SUBTYPES OF MUSCLE-INVASIVE BLADDER CANCER</strong></p> <p>Andrea Elizabeth Ochoa, B.S.</p> <p>Advisory Professors: David J. McConkey, Ph.D. and Joya Chandra, Ph.D.</p> <p>There has been a recent explosion of genomics data in …
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Improved profiling and classification of the breast cancer transcriptome
… quantification has highlighted the complex molecular heterogeneity of breast cancer and has contributed to recent improvements in clinical patient stratification. Difficulties in accuracy, sensitivity and reproducibility of molecular classifiers persist, and there exists a requirement for …
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The role of tissue inflammation in Kenyan women with breast cancer
… The immune landscape of breast cancer (BC) molecular subtypes from Sub Saharan Africa is understudied and findings are mainly extrapolated from studies in Caucasians. The objective of this study was to describe the cellular and signalling milieu of BC tumour microenvironment and its …
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Establishing the feasibility of using ctDNA for molecular profiling in DLBCL
DLBCL is a molecularly heterogeneous disease. Many clinical trials have failed to demonstrate improvements to survival by altering first line therapy. This may be due to failure to stratify patients in a way that reflects this molecular heterogeneity. Over the last 5 years, three large DLBCL …
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DEEP LEARNING ALGORITHM FOR MOLECULAR CLASSIFICATION OF ENDOMETRIAL CANCER FROM WHOLE SLIDE HISTOPATHOLOGY IMAGES
… cancer (EC) is a common malignancy whose molecular classification (POLEmut, MMRd, p53-abn, NSMP) guides prognosis and treatment. While MMRd and p53-abn can be assessed through IHC, POLEmut identification requires gene sequencing, which is costly and often unavailable. In this study, we …
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VERU-111 as an Oral Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer and Evaluation of Novel Tubulin Inhibitors for Cancer Therapy
… and higher mortality rates relative to other molecular subtypes. FDA-approved drugs, such as paclitaxel, are effective in treating TNBC. Yet, treatment failure is commonly observed due to the development of acquired chemoresistance, which remains a clinical challenge for TNBC therapy.</p>
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Molecular Classification of Bladder Cancer
… medicine, i.e. the exploitation of specific molecular properties in the treatment of tumors. The starting point for personalized medicine is a taxonomy of the tumor type, where genome, transcriptome, and/or proteome data is used to define molecular subtypes that make sense from biological and …
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SILVER NANOPARTICLES ARE EFFECTIVE FOR THE TREATMENT OF CLAUDIN LOW BREAST CANCER AND OTHER MESENCHYMAL CANCERS WITH HIGH ZEB1 EXPRESSION
… women will die from BC in 2017. With advances in molecular profiling, breast cancer has been divided into 5 molecular subtypes (luminal A, luminal B, HER-2 overexpressing, basal-like, and claudin-low) that have distinct genetic aberrations, morphological features, prognoses, and therapeutic …
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Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models
… are desperately needed. Understanding the molecular pathways involved in CaP initiation, progression, and resistance to treatment may help identify novel therapeutic targets. However, the molecular complexity of individual CaP genomes along with the heterogeneity observed between patients …
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Intrinsic subtypes and prognostic implications in epithelial ovarian cancer
… cancer subset and in histopathological and molecular subtypes of ovarian cancer. In study I, a gene expression profile differentiating the rare subgroup of Lynch syndrome-associated ovarian cancer from a matched sporadic cohort was identified. The Lynch syndrome-related expression profile …
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Genetic and Epigenetic Characterisation of Breast Tumours
… reflected in the identification of at least five molecular subtypes named basal-like, luminal A, luminal B, HER2-enriched and normal-like, which are believed to originate from different cell types and follow different progression pathways. In the current thesis, different genetic and epigenetic …
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Molecular Analysis of Breast Cancer Transcriptomes, Genomes, and Circulating Tumor DNA
… of individual isoforms was correlated to molecular subtypes, protein expression of clinical markers, and cancer stem cell (CSC) phenotypes in breast tumors and cell lines. The CD44S isoform was associated with expression of the CSC marker ALDH1 and the CSC phenotype CD44+/CD24- was …
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Molecular Classification of Basal Cell Carcinoma of Skin by Gene Expression Profiling
… features, their similarity and heterogeneity at molecular levels are not fully elaborated yet. Here, by performing comparative analysis of gene expression profiling of BCC, SCC, and normal skin tissues, we could classify the BCC into three subtypes of classical, SCC-like, and normal-like BCCs. …
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A Context-Forward In Vivo Functional Genomics Platform For Target Discovery and Establishing Vulnerability Context In Pancreatic Cancer
… of this disease into at least two broader subtypes, this alone has so far been insufficient to inform on more nuanced patterns of oncogenic dependency. We hypothesized that a more comprehensive and granular characterization of PDAC disease diversity is required to establish relevant context …
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Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy
… improvement in our understanding of the molecular determinants of metastasis, breast cancer relapse and death rates remain unacceptably high. The aim of the research presented in this thesis was to characterize the biomolecular heterogeneity of breast cancer across tumor progression …
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Estimating telomere length from whole genome sequencing data
… telomere length and previously identified molecular subtypes as well as cancer stage. In the second application, to the NIHR BioResource - Rare Disease cohort, we discover a previously unidentified variant in DKC1 that we propose is directly linked to short telomeres and an immunodeficient …
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Computational Approaches to Delineate Transcriptional and Functional Heterogeneity In Pancreatic Cancer
… tumors are highly complex ecosystems composed of molecularly distinct sub-populations that exhibit a spectrum of genetic features and associated phenotypes. Despite recent advances in the transcriptomic characterization of PDAC into at least two tumor subtypes, this alone has been insufficient to …
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Bayesian Integrative Analysis of Omics Data
… colorectal cancer incorporated with its four molecular subtypes. For each of the pathways that significantly differentiates subgroups, we detect important genomic drivers that can be viewed as “switches” for the pathway activity. To extend the analysis, finally, we develop proteomic based …
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Modeling and Validation of Gene Networks in Breast and Pancreatic Cancer
… mechanisms in novel predicted pancreatic cancer molecular subtypes. We uncovered three novel subtypes with targetable immune associated mechanisms and subtype-specific gene expression profiles with therapeutic and prognostic implications.
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