Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"molecular sensor"”.
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Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
… domain, we have created out of the ER a molecular sensor through which we can probe directly the conformational state of the receptor with high sensitivity. Thus, fluorophore-labeled ERs provide tools for studying receptor structure and function that nicely complement x-ray …
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Biomimetic sensor for in-vivo applications
… development of sensitive specific devices (e.g., molecular sensors) for the detection, diagnosis and monitoring of diseases, drug discovery, environmental detection of pollutants and/or biological agents has been an active area of research. A molecular sensor is a biomolecule or biomimetic …
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Glass Foundation Chemosensor Synthesis and Functionality Analysis
<p>Chemosensors are created through a series of reaction steps on controlled pore class (CPG) and terminate with a Cu<sup>2+</sup> metal binding site. Each monolayer of reactant insures that the metal binding site exposed to solution would serve as an indicator displacement assay (IDA) sensor. The …
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Cucurbit[n]uril-engineered Nano-constructs for Molecular Sensing
… NPs, where CB[8] is employed as a tethered supramolecular "receptor" to selectively capture target guest molecules. More specifically, CB[8] is threaded onto a methyl viologen (MV2+) axle and immobilised onto silica NPs with a surface density up to 0.56 nm$^{−2}$. Its use as an efficient and …
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Molecular Devices: Brakes, Rotors, Sensors, and Balances and the Non-Covalent Interactions That Power Them
… at the Bottom' predicted the advent of nano- and molecular-scale machines. Only recently has Feynman's vision begun to be realized with the syntheses of molecular devices that convert chemical or kinetic energy into controlled mechanical molecular motions. In this thesis, several types of …
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Molecular fluorescent reporters for force and smart surfaces for sensing cell-surface interaction
Molecular sensors are powerful because they make it possible to adapt the measurement to the sample instead of a sample to an instrument. Many reporter are available for measuring the chemical properties of a sample, but no purpose-built molecular sensors exist to report a sample's mechanical …
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Development of selective high-affinity fluorescent sensors for imaging neurotransmitters and application in cells and tissue
… we develop a series of selective fluorescent sensors based on a quinolone core designed to image neurotransmitters catecholamines, serotonin and glutamate. Included are the main design strategy, synthesis, spectroscopic data (UV/Vis and fluorescence) and their applications in cells and tissue. …
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Resonant Detection of Nano to Microscopic Objects Using Whispering Gallery Modes
… high Q are thus the ideal choice for a resonant molecular sensor. Although the resonance is stealth, an evanescent field extends from the microsphere surface the distance of a wavelength into the surrounding medium. This thesis demonstrates how label-free molecules binding to the microsphere …
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Development of stimulus-responsive polydiacetylene systems for molecular colorimetric detection
… to build up a stimulus-responsive structure for molecular colorimetric detections. In the first part of the work, pyridine-2-aldoxime, capable of binding pesticide malathion, was conjugated with diacetylene monomer, followed by the conjugate polymerization under UV irradiation to form a …
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Structural Studies of the Cold and Menthol Sensing Ion Channel TRPM8
… of noxious stimuli at the beginning of this sensory circuit is mediated by receptors or ion channels expressed at peripheral nerve endings, which respond to specific chemical, thermal, or mechanical stimuli and trigger ion fluxes that lead to firing of action potentials for signal …
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Molecular Sensors at the Nanoscale: Modeling and Technology
L'abstract è presente nell'allegato / the abstract is in the attachment