Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"molecular scaffold"”.
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Toward Hydrogenase mimicry : subjecting the problem to three different approaches
… These two kind of structures were further used a scaffold for Hydrogenase mimics. In the third approach, a theoretical computational study of the ferrocene-peptide derivatives is led. In order to investigate a wider range of ferrocene-peptide as a molecular scaffold, a molecular force field was …
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RNA transmission and expression from inert HIV candidate vaccine virus-like-particles
… This RNA plays a crucial role by serving as a molecular scaffold for the assembly of Gag structural proteins into particles. Non-pseudotyped VLPs that do not present any HIV envelope glycoproteins are regarded as inert particles as they contain no replicative nucleic acid and are presumed to be …
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Remaining Unperturbed by the Vibrational Response: Probing Vibrational Coupling, Relaxation, and Solvent Effects with 2D IR Spectroscopy
Understanding molecular function first requires an understanding of their native structuresand fluctuations of their environments. One of the most powerful ways to probe the dynamic behavior of molecular systems in solution is through the use of Two-Dimensional Infrared (2D IR) spectroscopy. 2D IR …
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NDE1 in the DISC1 pathway: interactions of schizophrenia-related proteins
… The DISC1 protein is believed to act as a molecular scaffold within the cell, binding to a large number of other proteins. Three of these protein interactors, Phosphodiesterase 4B (PDE4B), Nuclear Distribution Factor E (Aspergillus nidulans)-homologue 1 (NDE1) and NDE-Like 1 (NDEL1) all …
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Effect of rare and common single amino acid substitutions on DISC1 subcellular targeting and functional interaction with ATF4
… genetic candidate for psychiatric illness, is a molecular scaffold residing in multiple subcellular compartments, where it regulates the function of interacting proteins with key roles in neurodevelopment and plasticity. Both common and rare DISC1 missense variants are associated with risk of …
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IQGAP1 is a novel effector of gonadotropin-releasing hormone receptor signaling
… adherens junction-related proteins including the molecular scaffold IQGAP1 and the small GTPase Rac1. Subsequent investigation revealed that the association between Rac1 and IQGAP1 increased with GnRH receptor stimulation and that GnRH increased Rac1 activity. Demonstrating functional relevance, …
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The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
… receptor degradation. In searching for the molecular components involved in activity-induced receptor endocytosis, I identified the molecular scaffold, IQGAP1. IQGAP1 enhances AMPAR turnover through binding to ubiquitinated AMPARs and promoting receptor internalization. In addition, I also …
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Biosynthesis of the Nitrogenase FeMo-cofactor from Azotobacter vinelandii: Involvement of the NifEN complex, NifX and the Fe protein
… of FeMo-cofactor biosynthesis. The concept of a molecular scaffold in FeMo-cofactor biosynthesis is generally accepted in the field of nitrogenase. Previous work has implicated the products of nifE and nifN as providing the assembly site for FeMo-cofactor synthesis. Researchers were able to …
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Novel Schiff-base and Benzamide N,O-Donor Ligands for Development as Fluorionophores and Selective Metal Ion Binders
… of benzazines were prepared, some of them macromolecular derivatives, using a tetra tert-butylcalix[4]arene difunctionalised at the lower rim as a molecular scaffold. X-ray crystal structures for these calix[4]arene derivatives were obtained in four cases. Zn(II) complexes of this family of …
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The Biosynthesis and Function of Nitrogenase Metalloclusters
… for cluster formation and NifU serves as a molecular scaffold during [Fe-S] cluster assembly. Genetic and biochemical experiments involving amino acid substitutions within the N-terminal and C-terminal domains of NifU indicate that both domains can separately participate in …
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Synthesis and properties of novel macrocycles and related chromophoric benzenoid compounds
… rare H-H spin coupling in its <sup>1</sup>H NMR. Molecular modeling was used to determine the spatial relationship between the protons involved. Fluorinated [2,2]p-cyclophanes have been attracting increased attention. Poly(p-xylylene) polymers are materials of current technological interest. An …
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Development of Collagen Mimetic Mini-Fibrils with Tunable Collagenase Susceptibility
<p>Collagen fibrils are the primary molecular scaffold of all connective tissues and provide the essential support for cell migration and differentiation. Collagen fibrils represent one of the most complex molecular hierarchies: three polypeptide chains in Gly-Xaa-Yaa repeating amino acid …
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The Identification and Development of Small Molecule Inhibitors of Amyloid β Aggregation
… assay. Such work identified another molecular scaffold capable of exerting a strong inhibitory effect against A$\beta$42 aggregation. A selection of analogues was synthesised to improve the in vivo profile of this library, giving rise to a second lead inhibitory compound. The activity …
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The Use of High-Throughput Experimentation to Accelerate the Development of Methods for Complex Amine Synthesis
… make infrastructure investments. One important molecular scaffold that still requires new general synthetic methods to access is ⍺-branched amines. The ability of the α-branched amine motifs to modulate key biological interactions and regulate the physicochemical properties of molecules has led …
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BORAHETEROHELICENES: SYNTHETIC METHODOLOGIES AND PROPERTIES OF A NOVEL CLASS OF BORON Π-CONJUGATED SYSTEMS
… is an extremely powerful tool to provide organic scaffolds with optoelectronic properties as well as optimal packing in the solid state.[1] However, boron-doped PAHs (B-PAHs) often display low processability due to their poor solubility. The distortion of the molecular scaffold provides a suitable …