Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"molecular phenotyping"”.
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The assessment of forensic molecular markers for skin colour in South Africans
The scientific development of innovative molecular techniques has transformed the approach towards human identification. In forensic casework, the emergence of molecular phenotyping, or phenotypic prediction from DNA, has mitigated some challenges involving the unavailability of references samples …
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Assessment of 13 Forensic Molecular Markers for skin colour in South Africa
Molecular phenotyping is the use of informative genetic variation to estimate appearance. This concept can be applied in a forensic context to predict the appearance of suspects or decayed deceased individuals, which would otherwise remain unidentifiable. This concept has importance in a local …
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Understanding Genomes Through Engineered Structural Variation
… of underexplored regions. The data garnered from molecular phenotyping of novel genome architectures after randomization will allow predictive models to learn parameters beyond the limited diversity of our DNA.
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Deconvoluting genetic variants associated with aortic disease using stem cell models
… in vitro. This work is the first to perform deep molecular phenotyping on LOX, MYLK and SMAD4 genetic variants in the context of aortic disease. TAD variant heterozygous knock-ins were confirmed through molecular cloning and Sanger sequencing. Mutant VSMCs demonstrated TAD transcriptomic …
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THE INTERGENERATIONAL IMPACT OF ENVIRONMENTAL EXPOSURES: MOLECULAR INSIGHTS FROM MODELLING PLURIPOTENCY TRANSITIONS THROUGH THE HUMAN GERMLINE
… approaches based on the investigation of single molecular layers; (iii) the impossibility of studying multiple human generations in laboratory settings; (iv) the scarcity of multi-generational human data precisely linking environmental exposures and health outcomes. Considering the central role …