Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 199 for “"molecular pathways"”.
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Molecular pathways controlling DNA damage response
P53 is inactivated in around 50 % of human neoplasms and more than 26,000 somatic mutations of the p53 have reported in human cancers. P53 network is activated after cells are exposed to the DNA damage and depending on diverse conditions and type of DNA damage, p53 upregulation could lead to …
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Molecular pathways of silica nanoparticle formation and biosilicification
Biosilicification and silica nanoparticle formation occur in many modem terrestrial environments and they also played an important role in ancient geological settings. This thesis presents results from (i) field studies in Icelandic geothermal waters that aimed at quantifying the parameters that …
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Uncovering the molecular pathways of MBD5 in neurodevelopmental disorders
… phenotypically similar NDs and their overlapping molecular mechanisms remain unidentified. The chromosome 2q23.1 region is a newly discovered disease region. We have recently identified a novel ND, 2q23.1 deletion syndrome. The phenotype includes severe ID, significantly delayed speech, behavioral …
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Evaluation of molecular pathways associated with breast cancer disparities
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Engineering Internal and External Molecular Pathways in Artificial Cells
… functionality from the rational combination of molecular and nanoscale elements. These systems often take the form of artificial cells: micron-scale, cell-like constructs that display advanced behaviours such as communication, synthesis, storage of molecules, adap- tation and motion. Artificial …
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CELLULAR AND MOLECULAR PATHWAYS CONTROLLING SARS-COV2 ASSEMBLY AND EGRESS
… stations traversed by the virus and the molecular machineries that host cells put in place to counteract viral propagation have not been clearly established. Many genetic screens have been performed to find host factors involved in SARS-CoV-2 infection. We filtered the results of these …
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Defining the genetic and molecular pathways underlying motor neuron degenerative diseases
… due to a lack of understanding of the pathomolecular causes of disease. The identification of disease-associated genes provides a direct link between specific molecular pathways and disease pathogenesis. The work described in this thesis entails clinical, genomic and cellular studies which …
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Protein-lipid interactions in molecular pathways of Parkinson’s and Alzheimer’s diseases
… enhance the understanding of lipid-mediated molecular pathways in AD and PD, and provide insights that pave the way for future exploration of neurodegenerative disease pathology.
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Elucidation of the molecular pathways of lifespan extension by dietary restriction in yeast
In this dissertation, we demonstrate strong support for the antagonistic pleiotropy view of aging, reveal the illusion of sirtuin mediated longevity in 32 long lived alleles (hopefully steering the field farther from sirtuin research and toward more interesting things), show that there is indeed a …
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Efficient Identification and Comprehension of Molecular Pathways Associated with Irradiation Induced Hepatic Carcinogenesis
… and use this to show that mitochondrial pathways are dysregulated in response to 56Fe irradiation compared to non-irradiated control, in the wildtype mouse strain (C57BL/6NCrl.) Next we performed a comparative transcriptomic analysis in a mouse model for irradiation-induced HCC …
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Bioinformatics characterization of the molecular pathways impacted by immune challenges in the amygdala
… analysis provided insight into affected pathways, while protein-protein interaction networks identified non-canonical relationships impacted by MIA. Additionally, complementary analyses, such as transcription factor enrichment analysis, which was performed to investigate the interaction …
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Identification of the molecular pathways that mediate cytokine induced immunopathology of the gut epithelium
… canonical apoptotic and necroptotic signalling pathways. Furthermore, we identified a non-canonical role for caspase-8 and receptor-interacting serine/threonine-protein kinase 3 (RIPK3) in the cell death signalling pathway (Chapter-II). For the first time we report that IFN-γ and IFN-γ + TNF-α …
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On the molecular pathways supporting the development of structurally coloured cuticle in Hibiscus trionum
… buckling of the petal cuticle. In this PhD, the molecular pathways and mechanisms underpinning the production of nanoscaled petal ridges were investigated in Hibiscus trionum. Liquid extraction surface analyses coupled with mass spectrometry were conducted on striated and non-striated tissues, …
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The molecular pathways mediating the role of cyclooxygenase enzymes and prostaglandins in cervical neoplasias
… this model system the signal transduction pathways activated by prostaglandin E2-or seminal plasma-EP4 receptor interaction in HeLa wild type and EP4 receptor overexpressing(EP4S) He La cells were investigated. Treatment of EP4S cells with seminal plasma or prostaglandin E2 resulted in a …
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Using network inference to discover molecular pathways underlying cytokine synergism and age-related neurodegeneration
… "omic" methods can help shed light on molecular pathways underpinning diseases ranging from cancers to neurodegenerative disorders. However, effectively integrating information across these diverse data types is challenging. Network modeling approaches can help bridge this gap. In …
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MOLECULAR PATHWAYS ANALYSIS THROUGH MULTI-OMICS APPROACHES TO STUDY THE BIOLOGICAL BASIS OF ANOREXIA NERVOSA
… consequences. Despite its high heritability, the molecular mechanisms underlying AN remain unclear, and current treatment strategies are often ineffective. Recent advancements in genomics and metabolomics offer promising tools for understanding the genetic and biochemical pathways involved in AN. …
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Elucidating the Molecular Pathways Involved in the Fitness and Water Stress Response of Pseudomonas synxantha 2-79 in the Plant Rhizosphere
… wheat under surprisingly arid conditions. The molecular adaptation of 2-79-like bacteria to plants growing in dry soils is poorly understood. We hypothesized that the ability of 2-79 to colonize and persist in the rhizosphere of water-stressed plants is underpinned by the formation of hydrating …
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Identification of Novel Prostate Cancer Subtypes Using Stem/Progenitor Cell Models
… are desperately needed. Understanding the molecular pathways involved in CaP initiation, progression, and resistance to treatment may help identify novel therapeutic targets. However, the molecular complexity of individual CaP genomes along with the heterogeneity observed between patients …
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Identification of Novel Drivers of Haematopoietic Stem Cell Fate Using Low Cell Number Proteomics and Single Cell Profiling
… a complete characterisation of the underlying molecular pathways of HSC self-renewal in order to provide crucial insights into disease progression and to help inform novel strategies for ex vivo expansion for gene therapy applications. To date, advances in functional and molecular single cell …
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RAD51-MEDIATED ABASIC SITES PROTECTION PREVENTS REPLICATION FORK COLLAPSE.
… death if not properly repaired. While different molecular pathways have been described which seamless repair abasic sites over double-stranded DNA, the mechanisms by which AP sites are repaired within ssDNA to avoid catastrophic chromosomal breakage remain unclear. Genes encoding for some BER …
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