Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 41 for “"molecular networks"”.
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Computational Labeling, Partitioning, and Balancing of Molecular Networks
… in high throughput techniques enable large-scale molecular quantification with high accuracy, including mRNAs, proteins and metabolites. Differential expression of these molecules in case and control samples provides a way to select phenotype-associated molecules with statistically significant …
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Biology-informed communication protocols for bio-molecular networks
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Computational Tools for Molecular Networks in Biological Systems
Theoretical molecular biologists try to understand the workings of cells through mathematics. Some theoreticians use systems of ordinary differential equations (ODEs) as the basis for mathematical modelling of molecular networks. This thesis develops algorithms for estimating molecular reaction …
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Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… for organ-specific differentiation, the exact molecular mechanisms that specify endodermal progenitors to either the thymus or parathyroid lineage are not well defined. <em>Tbx1</em> is initially expressed throughout the 3<sup>rd</sup> pp endoderm, as it is required for segmentation of the …
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Deciphering host-parasite molecular networks mediating resistance to toxoplasma gondii
… two rat strains as models for deciphering host molecular mechanisms that mediate resistance to T. gondii. This can potentially unveil new strategies for developing effective therapies and vaccines against T. gondii infection. It is evident that the robust resistance of the LEW rat to T. gondii …
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Relationships between electron transport and redox center concentrations within molecular networks
… values for metalloprotein kinetics and a redox molecular diameter of 13 A (corresponding to Ru(bpy)$\sb3\sp{2+}$) are 1.9 $\times$ 10$\sp{-10}$ cm$\sp2$s$\sp{-1}$ and 5.0 $\times$ 10$\sp{-9}$ at 0.10 $M$ and 1.07 $M$, respectively.
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Fundamental limitations between noise and back-action in bio-molecular networks
In an interconnection of two components in a bio-molecular network, noise in the downstream component can be reduced by increasing the magnitude of the down-stream signal. However, this method of reducing noise increases the back-effect to the upstream system, called 'retroactivity', thereby …
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Two-dimensional molecular self-assemblies on surfaces studied by low-temperature scanning tunneling microscopy
Supramolecular self-assembly on surfaces is a promising bottom-up approach to fabricate two-dimensional (2D) molecular nanostructures over macroscopic areas. In our studies, a wide range of 2D molecular self-assemblies on surfaces and their formations of regular supramolecular arrays were …
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Dissection of Regulatory Networks Mediating Resistance and Susceptibility of Arabidopsis thaliana to the Downy Mildew Pathogen Hyaloperonospora parasitica
… conflict with each other. Understanding the molecular networks that trigger resistance, along with the molecular networks that pathogens might co-opt to infect susceptible plants, is important for developing the integrated, holistic perspective that is necessary for innovative development of …
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Integrative analysis of heterogeneous genomic datasets to discover genetic etiology of autism spectrum disorders
… to diagnosis, treatment and drug development. As molecular approaches to this challenge are time consuming and costly, computational approaches offer an efficient alternative. Such approaches aim at predicting and prioritizing genes for a particular disease of interest. State-of-the-art gene …
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The Immediate Early Response of Proliferating Myoblasts to One Bout of Electrical Stimulation
… precede differentiation, and preservation of the molecular networks involved within the regenerative process are necessary. Electrical stimulation is a common method of altering activity within a cell, and is known to alter the phenotype of myogenic cells. This thesis looks at the immediate …
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PLANT TOLERANCE TO DROUGHT: MODULATION OF TRANSCRIPTION FACTORS
… of water scarcity. In recent years several molecular networks concerned with stress perception, signal transduction and stress responses in plants have been elucidated. In this PhD thesis the various approaches used so far to produce transgenic plants having improved tolerance to abiotic …
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Development and Application of Network Algorithms for Prediction of Gene Function and Response to Viral Infection and Chemicals
The complex molecular machinery of the cell controls its response to various signals and environmental conditions. A natural approach to study these molecular mechanisms and cellular processes is with protein interaction networks. Due to the complexity of these networks, sophisticated computational …
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Materials with supramolecular chirality : liqid crystals and polymers for catalysis
… create synthetic materials with controlled supramolecular architectures. Incorporation of polymerizable groups within a liquid crystalline template can set the stage for the synthesis of anisotropic molecular networks. This dissertation details the synthesis and characterization of chiral liquid …
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Mathematical modeling of molecular mechanisms governing cell cycle progression in Caulobacter crescentus and differentiation of immune system progenitor cells
… mathematical modeling to study the underlying molecular networks driving observed behaviors of two systems. First, we apply systems biology and dynamic systems theory techniques to reveal new insights into the process of hematopoiesis. More specifically, we search the literature to deduce the …
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Toward the Understanding of Brain’s Molecular Language
… carbohydrates, and metabolites. This coordinated molecular interplay, we posit, ultimately gives rise to the complex neural circuits and behaviors observed in higher organisms. Intriguingly, Alfred Binet foreshadowed this perspective as early as 1889 when he suggested that even simple, …
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Novel Regulators of Somatic Cell Reprogramming
… of pluripotency are controlled by distinct molecular networks and uncover a novel regulatory program that is required for transition to transgene independence.
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Cell Type-Specific Roles of FoxP Transcription Factors in Vocalization and Cognition
… and FoxP1 function have linked some of these molecular functions with neurophysiological and behavioral phenotypes. Still, much remains unknown about molecular networks in the brain driven by these transcription factors, especially in specific regions and cell types. During my dissertation …
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The Differential Scheme and Quantum Computation
… equations. In many applications, e.g., molecular networks and hybrid Fermi-Pasta-Ulam systems, one must work with dynamical systems comprising both discrete and continuous components.</p> <p>Reasoning about and verifying the properties of the evolving state of such systems is currently a …
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Theoretical Design of Molecular Nanostructures for Exciton Control
… excitations, or excitons, via programmed molecular structures. The dynamics of these excitons enable energy and information transfer within molecular networks, positioning chromophore assemblies as ideal candidates for a number of technologies such as solar energy conversion, …
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