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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"molecular motors"”.
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Bidirectional transport by molecular motors
… long-range intracellular traffic is powered by molecular motors which transport various cargos along microtubule filaments. The microtubules possess an intrinsic direction, having a 'plus' and a 'minus' end. Some molecular motors such as cytoplasmic dynein walk to the minus end, while others …
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Ratchet models of molecular motors
… Um darüber hinaus die Geschwindigkeit des Motors in Abhängigkeit von seinem Treibstoff ATP angeben zu können, betrachten wir mögliche Reaktionskinetiken, die den Zusammenhang zwischen den unbalancierten Übergangsraten und der ATP-Konzentration bestimmen. Je nach Typ der Reaktionskinetik und …
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Towards Synthetic Molecular Motors Interfaced by AFM
Molecular machines are at the ultimate limit of miniaturization. Living organisms provide a variety of examples for such molecular machines, but in order to utilize and to control them, they need to be interfaced with the macroscopic world. On the other h and, there are synthetic molecular …
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Studying Processive Molecular Motors Inside Live Cells
Processive molecular motors are the proteins that transport various kinds of cargos within a cell. All processive motors have two motor domains that let the protein proceed by taking steps. These motor proteins can carry their cargos for microns by taking hundreds of steps before detaching form the …
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Different modes of cooperative transport by molecular motors
Cargo transport by molecular motors is ubiquitous in all eukaryotic cells and is typically driven cooperatively by several molecular motors, which may belong to one or several motor species like kinesin, dynein or myosin. These motor proteins transport cargos such as RNAs, protein complexes or …
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Movements of molecular motors : diffusion and directed walks
Bewegungen von prozessiven molekularen Motoren des Zytoskeletts sind durch ein Wechselspiel von gerichteter Bewegung entlang von Filamenten und Diffusion in der umgebenden Lösung gekennzeichnet. Diese eigentümlichen Bewegungen werden in der vorliegenden Arbeit untersucht, indem sie als Random Walks …
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Molecular motors and organelle transport in pigment cells
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Bidirectional cargo transport by microtubule-based molecular motors
… typically seen in vivo, indicating that the motors engage in a tug-of-war. When the complex hits a barrier, the cargo often reverses direction. In some cases, it tries several up-and-back motions, during which time the dynein likely pulls the cargo onto a different protofilament, and is …
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Investigating the role of molecular motors on chromatin organization
… investigations to unveil the role of molecular motors on chromatin organization in both one-dimensional and three-dimensional levels. In one dimension, we showed that the effect of remodel- ing enzymes can be well approximated by effective equilibrium models with rescaled temperatures …
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Force studies of multiple kinesin-1 and EG5 molecular motors
Kinesin-1 and Eg5 are molecular motors that are essential for eukaryotic cell growth and development. Kinesin-1 motors transport intracellular cargo along the microtubule cytoskeleton through and against the dense viscoelastic cytoplasm. Eg5 motors mediate proper mitotic, microtubule spindle …
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Noise in noise out - single molecule studies of molecular motors
Many cellular functions rely on the movements of molecular motors. Single molecule studies of these motors allow investigation into their step-sizes and stall forces. Such studies inevitably involve noise, which is inherent in the biological and imaging systems probing these motors. Having to work …
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Regulation mechanisms in molecular motors: engineering bioinspired transportation at micron-scale
… cargo transport, orchestrated by teams of molecular motor proteins on cytoskeletal tracks, is a fundamental process within eukaryotic cells. This thesis presents a comprehensive investigation into multi-motor cargo transport, employing an array of cutting-edge tools, including …
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Probing single-molecule dynamics of molecular motors and gene editing proteins
… imaging in studying two proteins systems: Molecular Motors and Gene Editing Proteins. Kinesin walks on cellular roads called microtubules and transports cellular cargos. Kinesin is one of the many types of molecular motors present in living cells. Generally, multiple kinesin motors are …
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Motion of filaments induced by molecular motors: from individual to collective dynamics
… phenomena, such as cytoplasmic streaming, molecular motors translocate along microtubules carrying cargoes which entrain fluid. The piconewton forces that motors produce can be sufficient to bend or buckle the filaments. When large numbers of such forced filaments interact through the …
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Modeling Pattern Formation in Biopolymer Systems induced by Reaction Kinetics and Molecular Motors
… two mechanisms to explain these patterns: first, motors lacking ATP form rigor bonds with actin inducing small bundles, which through a combination of reduced diffusivity and enhanced interaction cross-section can be transported more efficiently, allowing the system to cross one of the …
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Ultrafast excited state reaction dynamics in light-driven unidirectional rotary molecular motors and fluorescent protein chromophores
… systems are characterized: unidirectional molecular rotary motors and HBDI derivatives (synthetic chromophores of the green fluorescent protein (GFP)). In both cases, the excited state is selectively probed by ultrafast fluorescence up-conversion with a time resolution better than 50 fs. …
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The encapsidation protein from Lactococcus lactis asccφ28 as a novel system for the study of molecular motors
… their pervasiveness, our understanding of these molecular machines remains inadequate. Some of the simplest examples of molecular motors are found in many bacteriophages and some eukaryotic viruses. For example, many phages package their genomes into preformed empty protein shells, or procapsids, …
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Role of Molecular Motors and Maps in Spindle Dynamics and Chromosome Segregation in the Fission Yeast Schizosaccharomyces Pombe
… which is composed of microtubules (MTs), motors and microtubule associated protein (MAPs). Motors such as kinesins generate forces within the spindle while MAPs perform functions such as organize the spindle pole and maintain the bipolar spindle. Both motors and MAPs contribute to spindle …
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Directed transport without net bias in physics and biology
… of the basic atom wire configuration. Molecular motors also generate directed transport without net bias. The processive molecular motors, of which myosin-V and kinesin are the most well known, 'walk' along the cytoskeleton, the internal skeleton of the cell. Both myosin-V and kinesin …
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