Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"molecular mimicry"”.
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Creation of Bioinformatics Approaches to Understand Host-Pathogen Molecular Mimicry
… survival and proliferation. Also called molecular mimicry, imitation of host biomolecules has been observed to target a wide range of processes, including host signaling pathways and the immune system. Identification of molecular mimicry can provide insights into pathogen virulence and …
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The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry
… to other arthritides. These data suggest that molecular mimicry between viral and host proteins has the potential to lead to antigen-driven high-affinity RF IgG immunological reactivity in RA. Finally, we broadened our study of mimicry in RA by the investigation of citrullinated autoantigens. …
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Predicting motif mimicry in viruses
… that host-pathogen PPI data can be used to study molecular mimicry in viruses and to discover novel SLiMs. An in-silico peptide exchange approach was developed and applied to provide additional validation of predicted mimicry candidates. Despite limitations of this technique in large-scale …
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Ehrlichia chaffeensis mediates Hedgehog and Hippo signaling to activate an anti-apoptotic cellular program
… ligand mimic and ubiquitin ligase. Molecular mimicry is a survival strategy utilized by an array of pathogens to facilitate host-pathogen interactions and exploit host machinery. Recent publications from our laboratory demonstrate that TRP120 is a ligand mimic that directly interacts …
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Transcriptomic and proteomic analysis of Ascaris suum larvae during their hepato-tracheal migration
… effective vaccine, a better understanding of the molecular biology and host-parasite relationships of Ascaris is required. In chapter two, a transcriptome dataset was generated and analyzed in order to identify both the highest transcribed and stage-specific transcripts for each larval stage, the …
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The Immunopathogenesis of HLA B27-associated Spondylarthritis and Acute Anterior Uveitis
… been implicated in disease pathogenesis, whereby molecular mimicry results in an antigen derived from the microorganism to cross-react with a molecule in the host, triggering an inflammatory response. Lumican is an extracellular molecule that is found in both the eye and joint and has important …
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Detection of staphylococcal enterotoxins in patients with rheumatoid arthritis or closed fracture
… mechanisms include the hygiene hypothesis and molecular mimicry. Due to the widespread prevalence of RA, it has been hypothesised that the pathogenesis could involve a common bacterium. In RA, one potential bacterial candidate that has been suggested is S.aureus. Current published data averages …
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Evolution of targets at the host-pathogen interface
… of SARS-CoV-2 cell entry <br>The evolution of molecular mimicry mechanisms by the SARS-CoV-2, SARS-CoV-1, and MERS-CoV spike-receptor are explored. In short, diverse protein classes were predicted to interact with the spike protein, which suggest novel host cell receptors. The potential for the …
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The Dynamic Interplay Between Lentiviral Vif and Human APOBEC3 Proteins
… lentiviral Vif and human A3 enzymes, from the molecular determinants of this interaction to its implications in HIV-1 transmission within a large patient cohort. This has been addressed through three separate studies. The primate A3 repertoires show considerable variations likely due to …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… infects mononuclear phagocytes and has evolved molecular strategies to reprogram the host cell involving secreted effectors that interact directly with the host cell targets. Recently, we have shown E. chaffeensis evasion of innate defenses of the macrophage involve activation of Wnt, Hedeghog …
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Controlling Gene Expression with Synthetic Molecules
Aberrant gene expression patterns have been implicated in several pathological states. Synthetic molecules capable of functionally mimicking native transcription factors and regulating gene expression in a specific and predictable manner may represent a new paradigm in drug development. Native …
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Elucidating the Secreted Bacterial Kinome
Pages vi-x are misnumbered as pages v-ix.
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COMPUTATIONAL APPROACHES IN STUDYING INHIBITOR DEVELOPMENT IN HAEMOPHILIA A PATIENTS
L'emofilia A è un disturbo emorragico recessivo legato al cromosoma X, causato da mutazioni nel gene F8, che determinano una carenza o un malfunzionamento del fattore VIII (FVIII) della coagulazione. Una delle principali complicazioni cliniche nei casi gravi è lo sviluppo di alloanticorpi …
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Der Einfluß von Virusinfektion und Impfung auf autoreaktive T-Lymphozyten bei der Multiplen Sklerose
In der sogenannten ViMS-Studie, bei der MS-Patienten und gesunde Kontrollpersonen mit einer Influenza-Spaltvakzine geimpft und für einen zum Teil viermonatigen Zeitraum im Verlauf nachbeobachtet wurden, ergab sich weder mit dem sensitiven IFNg-ELISPOT noch mit der quantitativen RT-PCR ein Anhalt …
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… of environmental influences were concentrated on molecular mimicry with microbial peptides (Bray et al., 1983; Wucherpfennig et al., 1995; Challoner et al., 1995; Gautam et al., 1998; Ufret-Vicency et al., 1998; Burgoon et al., 1999). Epidemiological studies identified a link between milk …