Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 71 for “"molecular medicine"”.
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Supramolecular Architectures in Molecular Medicine: Visualizing and Manipulating the Structure of Protein-Lipid Surfaces
… fluorescence lifetime behavior of oriented biomolecular surfaces. These studies have revealed differences in lifetime between differentially oriented myoglobin molecules, consistent with differential accessibility of the heme pocket to quenching by oxygen. A computational study of the …
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Supramolecular Architectures in Molecular Medicine: Visualizing and Manipulating the Structure of Protein-Lipid Surfaces
Molecular complexes play a number of key roles in medicine and biology. Understanding how these complexes behave at interfaces, as well as controlling their structure, is of fundamental interest to science and technology. Lipoproteins, a complex of protein and lipid, serve as the primary …
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Improving the delivery and efficacy of molecular medicine via extracellular matrix modulation : insights from intravital microscopy
… of tumors is a major barrier to the delivery of molecular medicine. We used fluorescence recovery after photobleaching combined with intravital microscopy to quantitate the transport properties of the tumor interstitium. We found that the presence of fibrillar collagen correlated with hindered …
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Contemporary interventions in historic fabric: context and authenticity in the work of Gabriel Fagan
… Cape Town’s Institute of Infectious Disease and Molecular Medicine. These projects are all essentially contemporary interventions in historic fabric and each contains easily identifiable and iconic new portions – the sail-like roof of the Dias Museum, the glass lift shaft at SAB and the circular …
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From bench to bedside, to track and field: The context of enhancement and its ethical relevance
… technologies are translated directly from the molecular medicine laboratory to "track & field," analysing: the scientific and regulatory context of gene enhancement, and on which basis it is classified as doping; how the International Olympic Committee and the International Association for …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… Arsenic trioxide (As2O3) is one of the oldest medicines used for treatment of different diseases and it is today used as first-line treatment for patients with relapsed or refractory acute promyelocytic leukemia. Here, we demonstrate that As2O3 is cytotoxic to SCLC cells and xenotransplanted …
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Evaluation of Myogenic Differentiation Potential of BMD iPSCs in vitro and the Effect of Ubiquitination Inhibitors on Dystrophin Stability in vivo
… that utilizes human iPSCs transplantation and molecular medicine.</p>
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Development of synthetic RNA-targeting catalysts from biostable nucleic acid analogues
RNAs are major biomolecular players in biology and disease, and are a rich source of novel drug targets for molecular medicine. However, therapeutic modulation of specific RNAs remains a significant technical challenge. Single-stranded nucleic acids can fold into complex three-dimensional …
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A functional and therapeutic investigation of ciliopathy proteins and ciliopathies
This thesis aims to investigate new functions for ciliopathy proteins and identify candidates for therapeutic application. The ciliopathies form a class of genetic diseases whose aetiology lies in the primary cilium. Over 30 genes have been identified as mutant in ciliopathies and their proteins …
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Streptavidin-cytokine fusion proteins for use as adjuvants in cancer vaccines
… separated by a short polypeptide linker region. Molecular cloning techniques were used to generate DNA expression constructs encoding the recombinant fusion proteins which were expressed in an inducible bacterial system using plasmid expression vector pCR(R)T7/NT-TOPO(R). The expressed …
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Preparation and evaluation of polymer microspheres for enhanced lateral flow immunoassay: the case study for malaria
We proposed that the development of a new high capacity polymer microsphere technology, termed ReSyn, could be developed as viable detection reagents for lateral flow technology. This body of work outlines the development of this new high capacity polymer microsphere technology for suitability to …
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Development of recombinant immunotoxins targeting overexpressed cell surface biomarkers trophoblast cell-surface antigen 2 and mesothelin for cervical cancer treatment
… Research Unit Institute for Infectious Disease & Molecular Medicine South African Research Chair in Cancer Biotechnology ETA represents the wild type (wt) of Pseudomonas exotoxin A, a highly cytotoxic protein toxin produced by a bacterium that inhibits protein synthesis in host cells leading to …
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Regulation of Hematopoietic Stem Cells
This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate …
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Targeting the hematopoietic stem cell to correct osteopetrosis
This thesis focuses on developing stem cell targeted gene therapy for the severe hereditary disorder Infantile Malignant Osteopetrosis (IMO) as well as increasing the understanding of how the genetic defect present in IMO affects the hematopoietic stem cells and hematopoiesis in general. IMO is a …
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THE HYPOXIC HEMATOPOIETIC STEM CELL NICHE Consequences of Hypoxia-induced Transcription on Stem Cell Fate
Hematopoiesis is the process of blood formation that originates with the hematopoietic stem cell (HSC), a cell type that is responsible for the life-long supply of mature blood cells. HSCs are defined by their ability to self-renew as well as giving rise to differentiated cells of all blood …
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Modeling Diamond-Blackfan Anemia in the Mouse: Disease Pathogenesis and Evaluation of Novel Therapies
… mice recapitulate many of the phenotypic and molecular features seen in patients, and are therefore well suited for the evaluation of novel therapies. In article II we used these mouse models to assess the therapeutic potential of the amino acid L-leucine in the treatment of DBA. We show that …
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Impact of measles epidemic at Red Cross Children's Hospital, 2009-2010 : a retrospective record review
Includes abstract. Includes bibliographical references.
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A review of recruitment strategies within the Clinical Infectious Diseases Research Initiative (Cidri) Group from 2007-2013, 4 studies
The Clinical Infectious Diseases Research Group [CIDRI] has conducted high impact research over the last decade in Cape Town specifically in the townships of Khayelitsha and Mannenberg. None of this research would have been possible without robust strategies to recruit and retain study …
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Epidemiologic synergy - the contribution of heterosexual HIV transmission to the spread of HIV among men who have sex with men (MSM) in South Africa
Background: Could heterosexual HIV transmission be a driver of HIV infections that occur in men who have sex with men (MSM)? Noting the disproportionately high HIV prevalence among MSM across a variety of settings, this subpopulation is often considered as sources of new infections, overlooking the …
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