Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 297 for “"molecular interactions"”.
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Spectroscopic Studies on Molecular Interactions
Made available in DSpace on 2014-12-09T17:36:30Z (GMT). No. of bitstreams: 1 7013255.pdf: 3336530 bytes, checksum: 8a9cd8480a7ae77327c43396f53395c8 (MD5) Previous issue date: 1969
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Studies of molecular interactions using physical techniques
… described in this thesis concern the molecular interactions between polar solute molecules and various aromatic compounds in solution. Three different physical methods were employed. Nuclear magnetic resonance (n.m.r.) spectroscopy was used to determine the nature and strength of the …
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Molecular interactions of plant cell wall polymers
… future. For each of these applications, the interactions between the polymers in secondary cell walls are important. Previously, it was proposed that glucuronic acid side chains on xylan form ester bonds with lignin, and that this cross-linking might be important for cell wall properties. …
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Understanding of Molecular Interactions and Reversibility in Silylamines
… liquid (RevIL) state and non-conducting in its molecular liquid (ML) state. Thus, silylamines could serve as model compounds for the thermally switchable battery electrolyte concept. However, the temperature dynamics and ion-ion interactions within the silylamine system need to be understood …
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Molecular interactions and their impact on life sciences
… evolved in cells and tissues. The network of interactions of such biomolecules allow for the formation and regulation of the basic machinery of life, yet is commonly studied under non-physiological conditions. In order to characterise the behaviour and function of such biomolecules, they have …
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Microglia and Myelin: Improved Tools and Molecular Interactions
… including microglia as providers of important molecular cues in myelination. Studies dissecting these cues have made great strides, yet the functions of many candidate molecular mediators remain incompletely defined, at least in part due to the scarcity of suitable tools. The goal of my thesis …
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Novel Applications of Biolayer Interferometry to Investigate Molecular Interactions
<p>In this study, BLI is used to explore various molecular interactions to demonstrate molecular binding and to provide quantitative characterization of binding kinetics and affinities of phage-protein and DNA-protein interactions. The results of this study demonstrate novel use of biolayer …
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Controlling molecular interactions to define interfacial phenomena and structure
… of the properties of these components and the interactions between each in mixtures ensures that formulation is more of an engineered approach than a “black” art. In this thesis, the interactions between polymers and small molecules were probed in various states: solution, gel and foam. The …
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Molecular Interactions between Apicomplexan Parasites and their Host Cells
… therapeutics. To elucidate host-parasite interactions in the Plasmodium liver stage, we implemented a forward genetic screen to identify host factors within the human druggable genome that are critical to P. berghei infection in hepatoma cells, as well as RNA-seq approaches to delineate …
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Nuclear magnetic resonance studies of molecular interactions and structures
… nuclear magnetic resonance spectroscopy, of the molecular interactions occurring in mixtures of benzene and cyclohexane to which either chloroform or deutero-chloroform has been added. The effect of the added polar molecule on the liquid structure has been studied using spin-lattice relaxation …
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Steered molecular dynamics: a tool to investigate molecular interactions
Steered molecular dynamics (SMD) induces unbinding of ligands and conformational changes in biomolecules on time scales accessible to molecular dynamics simulations. Time-dependent external forces are applied to a system, and the response of the system is analyzed. In this work, the application of …
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MicroCantilever (MC) based nanomechanical sensor for detection of molecular interactions
… stress generation associated with chemical or molecular binding on functionalized microcantilevers. Formation of affinity complexes on cantilever surfaces leads to charge redistribution, configurational change and steric hindrance between neighboring molecules resulting in surface stress change …
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Development of computational tools to model molecular interactions for medicinal chemistry
… techniques to be dependable, important interactions must be properly modeled and the techniques must be rigorously tested. In this work, I first introduce an important interaction for drug design, the halogen bond (X-bond). We consider how decades of work has come closer to properly …
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Deciphering molecular interactions in presynaptic dense projection formation in C. elegans
… comprise a presynaptic neuron, which releases molecular messengers such as neurotransmitters, and a postsynaptic cell, which receives these messages and respond appropriately. To perform its specific role the presynapse utilises a distinct set of proteins at a site known as the active zone, …
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Analysis of molecular interactions in the presence of side chain flexibility
Protein-protein and protein-ligand interactions are ubiquitous in biology. For many proteins, these interactions can be well simulated by assuming rigid body association, resulting in powerful predictions from protein-protein docking. These methods have also been applied to sample ensembles of …
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Insights of Taste Masking from Molecular Interactions and Microstructures of Microspheres
The effects of taste masking are determined by interactions between drug and excipients as well as the microstructures of the particulate drug delivery systems (DDS). Cyclodextrin (CD) is a widely used taste masking agent, to which the relationship between kinetic parameters (Ka and Kd) of a drug …
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