Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"molecular interaction"”.
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Thermal Diffusion and Molecular Interaction in the Critical Region
Made available in DSpace on 2014-12-05T17:15:04Z (GMT). No. of bitstreams: 1 0004422.pdf: 4227402 bytes, checksum: ef4725e0486805295b7c4a2c9d3e9374 (MD5) Previous issue date: 1952
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Automatic Reconstruction of the Building Blocks of Molecular Interaction Networks
… highly intricate and difficult to interpret. The molecular interaction networks generated from evaluation of those experiments suggest that cellular functions are carried out by modules of interacting molecules. Reverse-engineering the modular structure of cellular interaction networks has the …
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Comparative analysis of molecular interaction networks : the interplay between spatial and functional organizing principles
The study of biological interaction networks is a central theme in systems biology. Here, we investigate common as well as differentiating principles of molecular interaction networks associated with different levels of molecular organization. They include metabolic pathway maps, protein-protein …
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Investigation of Akirin Nuclear Localization and the Molecular Interaction between Akirin and Taf4 in Drosophila
… musculature development through its genetic interaction with the basal transcription factor, Taf4. We did this by analyzing muscle patterning in <em>akirin</em>, <em>taf4</em> double heterozygous mutants. Our data confirm a genetic interaction between <em>akirin</em> and <em>taf4</em>. …
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Design and fabrication of a microfluidies gradient generator system for high-throughput molecular interaction studies
… on seeded cells allowing for high-throughput molecular interaction analysis. The microfluidics system provides a way to study and analyze cell response in the presence of a combination of biochemical signals.
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The Molecular Interaction Between Type Ii Diabetes and Alzheimer’S Disease Through Cross-Seeding of Protein Misfolding
… protein. Our hypothesis is that the pathological interactions between T2D and AD may in part occur through cross-seeding of protein misfolding. To test this hypothesis, we examined how each respective aggregate (Aβ or IAPP) affects the disparate disease pathology through <em>in vitro</em> and …
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Investigation of the Molecular Interaction Between Pyr mRNA and the Bacillus Subtilis Attenuation Regulatory Protein, PyrR
… nt long. The stoichiometry of the PyrR-pyr mRNA interaction was determined to be equimolar using a gel mobility shift titration assay. The effects of 31 structural variants of BL2 on PyrR binding were studied. Twelve of the variations had little effect, three caused a moderate defect in binding, …
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Systems Biology in an Imperfect World: Modeling Biological Systems with Incomplete Information
… the complex underlying network of biochemical interactions which allow an organism to respond to environmental stimuli. Models of these biological interactions serve as a tool to both codify current understanding of these interactions as well as a starting point for scientific discovery. Due to …
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Regulation of Hepatic Detoxification Enzymes by Glucosinolate Breakdown Products in Cruciferous Vegetables
In conclusion, there is a molecular interaction between crambene and I3C that explains the synergism in phase II enzyme induction after exposure to combinations of these two components. In addition to this, active glucosinolate breakdown products studied here also have anti-promotional effects …
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Biomedical data sharing and analysis at scale : privacy, compaction, and integration
… genomes, single-cell sequencing experiments, and molecular interaction networks. The unprecedented scale, variety, and distributed ownership of emerging biomedical datasets present key computational challenges for sharing and analyzing these data to uncover new scientific insights. This thesis …
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Bridging Methodological Gaps in Network-Based Systems Biology
… cell is controlled by a complex network of interactions among genes, proteins, and other molecules. A major goal of systems biology is to understand and explain the mechanisms by which these interactions govern the cell's response to various conditions. Molecular interaction networks have …
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Nuclear magnetic resonance studies of molecular interactions and structures
… nuclear magnetic resonance spectroscopy, of the molecular interactions occurring in mixtures of benzene and cyclohexane to which either chloroform or deutero-chloroform has been added. The effect of the added polar molecule on the liquid structure has been studied using spin-lattice relaxation …
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Polysulfone mixed matrix membranes with biosynthesis nanoparticles: enhancement of interface compatibility and antibacterial membrane seperation process
… an essential factor for water permeability. The molecular interaction between molecules was investigated using Dynamic mechanical analysis (DMA) and silver leaching analysis by Inductive coupled plasma mass spectrometer (ICP-MS). vi As revealed, the strength of molecular interaction between AgNPs …
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Synthesis, characterisation and coordination chemistry of novel N-alkyl- and N,N-dialkyl-N'-acylthioureas
… indicates that an intramolecular hydrogen bond locks the potentially bidentate chelate moiety into a planar six-membered ring with an overall rod-like molecular structure. The rod-like structure of the N-alkyl-N'-benzoylthioureas is exploited and the synthesis and …
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Electrokinetic trapping of biomolecules : novel nanofluidic devices for proteomic applications
… nanofluidic filters. With the distinct ionic and molecular interaction at the nanoscale, nanofluidic systems can potentially outperform current sample preparation and molecular detection techniques. Aiming to investigate and expand the applications of these techniques, this thesis work involves …
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GPU-Optimized Graph Theory Analysis of Allosteric Protein Signaling Networks
… where we abstracted the residues and their interactions as nodes and edges, respectively, to characterize the molecular interaction network. We then systematically compare the change in the betweenness upon the deletion of the residue, akin to mutagenesis experiments performed in the …
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Multiscale computational modeling of nanofluidic transport
… to better understand the mechanisms of intrinsic molecular interaction in nanofluidic applications. We performed ab initio molecular dynamics to study the nanoscale solvation behavior of selected ions on finite graphene models. The degree of charge transfer between ion and water, and the effect of …
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Effects of Chemical and Enzymatic Modifications on Starch and Naringenin Complexation
… FT-IR results confirmed the occurrence of molecular interaction between starch and naringenin in both complexes. Melting properties were significantly influenced by the type and degree of substitution. The present results demonstrate that the complexation of starch with naringenin can be …
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A novel 4-valued discrete network for the analysis of signalling events integrating protein interaction and gene expression data applied on hematopoietic diefferentiation
… cellular models can be made with the aid of interaction databases and gene expression profiles. Starting from molecular interaction-databases complex networks are generated comprising all known cellular signalling paths. But, not all of them play a role in a specific cellular model. The …
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