Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"molecular engineering"”.
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Molecular Engineering Approaches against Germs, Spores and Biofilm Formation
… In fact, the very subject has posed engineering challenges and incented scientific questioning for as long as the history of modern day microbiology and materials science themselves. With the rapid advances of molecular engineering in the past few decades, engineers as well as …
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Novel molecular engineering approaches for genotyping and DNA sequencing
… synthesis (SBS) appears to be a very promising molecular tool for genome analysis with the potential to achieve the $1000 Genome goal. However, the current short read-length is still a challenge. Therefore, the second part of the thesis focuses on strategies to overcome the short read-length of …
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Altering the Crystal Packing of Boronsubphthalocyanine Derivatives through Molecular Engineering
… for BsubPc crystals that occurs when the intermolecular interactions between the axial phenoxy segment and the BsubPc ligand are increased. We present two methods for achieving this new motif, one is through addition of a π-Br interaction and the other is through creation of a strong π-acid/ …
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Molecular Engineering of Self-Assembled and Mechanically Robust Polymer Solar Cells
Photovoltaic energy conversion is a promising option to supply renewable zero pollution energy on a global scale. In order to compete with energy derived from fossil fuels, the cost must be reduced. Polymer based solar cells have emerged as technology for harvesting renewable energy from sunlight. …
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Molecular Engineering of a Single-Chain FV Antibody Fragment to Femtomolar Affinity
… suggests a potentially general strategy for engineering scFv antibodies for high affinity binding to target ligands. The results of these studies clearly demonstrate the robustness of the yeast surface display system for quantitatively optimizing recognition parameters of biological …
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Molecular engineering strategies for expanding the capabilities of fluorescent zinc (II) sensors
… zinc(II) fluxes in HeLa cells. Chapter 4: Unimolecular Two-Fluorophore Ratiometric Zn²⁺ Sensing Systems. Dichlorofluorescein compounds covalently bound to zinc(II)-insensitive reporter fluorophores via a rigid cyclohexyl linker have been prepared and characterized. Based on favorable …
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Molecular Engineering of Dipolar and Octupolar Non-Linear Optical Materials for Next-Generation Telecommunications
… of the telecommunications industry, the molecular engineering and design of new organic materials continues apace. Such materials are particularly attractive on account of their fast optical response times, and superior non-linear optical susceptibilities, relative to their traditional …
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Computational structure-based modeling and analysis with application to rational and evolutionary molecular engineering
… each protein presents to evolutionary protein engineering procedures.
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Molecular engineering of gold nanorod surfaces: towards improved physical properties and understanding nanoparticle-cell interactions
… to cultured cells. Herein, three surface-engineering approaches to enhance the colloidal physical stability and biocompatibility of gold nanorods have been examined: 1) electrostatic approach via overcoating with polyelectrolytes; 2) covalent approach via surfactant polymerization; 3) and …
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Molecular engineering of new protein labeling methodology based on rational design and in vitro evolution
Site-specific labeling using E coli biotin ligase (BirA) and its 15-amino acid "acceptor peptide" (AP) has been applied to study the function of various cellular proteins. In order to extend the capabilities of biotin ligase-based labeling, we engineered key elements of the labeling platform. First …
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Structure-property engineering and device fabrication of conjugated polymers by chemical vapor deposition
This thesis focuses on the in-situ molecular engineering of chemical vapor deposition (CVD)-synthesized soft materials and device applications. High quality and large-scale synthesis of soft materials are the foundation of soft electronics. CVD approach has proved to be a low-cost and scalable …
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EVOLUTION AND CHARACTERIZATION OF A NEW REVERSIBLY PHOTOSWITCHABLE CHROMOPROTEIN
We report the molecular engineering and spectral characterization of a new reversibly photoswitchable chromoprotein, B11 a variant of thermostable green protein (TGP) that has been evolved for favorable solubility, thermostability, and enhanced crystallization properties. Its 2.5 \xc5 joint X-ray …
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Development of electronic structure and kinetics methods for the rational design of electrocatalysts
… of breaking these relations with careful molecular engineering of the GCC active sites.
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Molekulinių spinduolių optimizacija naujos kartos organiniams šviestukams /
… is rapidly expanding due to the constant molecular engineering of novel organic compounds and advances in device technology. Currently, organic materials are used in organic light-emitting diodes (OLEDs), organic thin-film transistors, solar cells and sensors, due to its especial …
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Optimization of molecular emitters for new generation OLEDs /
… is rapidly expanding due to the constant molecular engineering of novel organic compounds and advances in device technology. Currently, organic materials are used in organic light-emitting diodes (OLEDs), organic thin-film transistors, solar cells and sensors, due to its especial …
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Low Absorption Liquid Crystal Materials for Midwave Infrared
… absorption loss. To reduce absorption, some molecular engineering approaches have been considered, such as deuteration, fluorination, and chlorination. The fluorine and chlorine not only act as the polar group to provide dipole moment but also helps shift some vibration absorption bands …
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Modeling the Geometry of Neural Network Representation Spaces
… big cliques or small cuts, which arise in molecular engineering and network science.
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Molecular Structure-nonlinear Optical Property Relationships For A Series Of Polymethine And Squaraine Molecules
… the investigation of the relationships between molecular structure and two-photon absorption (2PA) properties for a series of polymethine and squaraine molecules. Current and emerging applications exploiting the quadratic dependence upon laser intensity, such as two-photon fluorescence imaging, …
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Cellular Uptake of Cystatin C. Subcellular localisation and intracellular effects of a secreted cysteine protease inhibitor
… In most cases the uptake was decreased after molecular engineering, but for the variant W106F-cystatin C it was increased. The substitution of W106 affects the cathepsin-inhibiting properties of cystatin C, but it is still an efficient inhibitor of legumain. The increased uptake of this …
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Lentiviral Vector Engineering for High-Throughput Immune Profiling
… In Chapter 2 of this thesis, we describe our molecular engineering approaches that enabled the development of VSVGmut, an efficient and modular targeted pseudotyping strategy. In Chapter 3, we leverage VSVGmut and further advances to enable one-pot library on library antigen identification …
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