Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"molecular diversity"”.
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Functional and Molecular Diversity of the Diatom Family Leptocylindraceae
… focus of this PhD project is the functional and molecular diversity of Leptocylindraceae diatom species, the study of which can lead to a better understanding of long standing questions regarding the ecology and evolution of phytoplankton. A wide range of tools, spanning from microscopical …
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Specific connectivity and molecular diversity of mouse rubrospinal neurons
… However, the somatotopic organization and molecular diversity of supraspinal projection neurons, and the circuitry that underlies their contribution to motor output, remain incompletely understood. The evolutionary emergence of direct descending projections onto motor neurons has been …
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On the molecular diversity of dimethylsulphoniopropionate catabolism by marine bacteria
… source for microbial life. In recent years, the molecular basis of DMSP catabolism by marine bacteria has begun to be unravelled, through the discovery of six different DMSP lyases and a DMSP demethylase, as well as downstream pathways. From these studies, it is becoming evident that there is …
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Molecular diversity of Primula apennina and phylogeny of Primula Subsection Euauricula
… (Italy). ISSR were used to detect the genetic diversity within and among six populations representative of the species distribution range. High levels of genetic diversity were revealed both at population (PPB = 75.92%, HS = 0.204, Hpop = 0.319) and at species level (PPB = 96.95%, HT = 0.242, …
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Molecular diversity and coat protein expression of Sweet potato leaf curl virus
Leaf curl virus diseases have been reported in sweetpotato throughout the world. One of the causal agents is Sweet potato leaf curl virus (SPLCV) which belongs to the genus Begomovirus (family Geminiviridae). In the United States, SPLCV has been found infecting an ornamental sweetpotato and several …
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Exploring the molecular diversity and biomedicinal potential of marine invertebrates and South African actinomycetes for tuberculosis drug discovery
… with its resistant strains. Less explored and biodiversity-rich ecosystems such as the marine environment and South Africa (SA)'s fauna and flora have been a source of new bioactive natural products (NPs). A range of marine invertebrates and SA actinomycetes were therefore studied for the …
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Investigating virus-host interactions in a changing Arctic Ocean
… Basic knowledge of the spatial variability and diversity of surface AO microbial eukaryotes, however, is limited. M. polaris is known to occur in a variety of different environments in the AO, yet its molecular diversity and mechanisms underlying its ecological success are not well understood. …
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Molecular and functional study of splice variations of the L-type voltage-gated calcium channel CaV1.2 alpha1-subunit
… Alternative splicing enriches the functional diversity of the pore-forming CaV1.2 alpha-1 subunit. Systematic screening of the human CaV1.2 alpha-1 gene by the transcript-scanning method revealed 19 of the 55 exons were subjected to alternative splicing, and two of these were novel exons. A …
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Screening for fluorescent and chromoproteins from South African sea anemones
… a lack of correspondence between taxonomic and molecular data (Daly et al. 2008). Therefore, a deeper exploration into Cnidarian molecular biology is needed to establish these as an evolutionary model organism. Gene discovery from various marine invertebrates has facilitated the recovery of …
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Postnatal specialization of astrocyte regional heterogeneity in the mammalian brain and improved tools for studying glia
… Though many studies have uncovered significant molecular distinctions between astrocytes from different brain regions, the developmental trajectory of this regional heterogeneity requires further systematic study. Chapter 1 of this thesis provides a detailed literature review on the development …
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Analysis of coordinated skipped exon pairs using single molecule sequencing technology
… protein. This process is a major source of molecular diversity, as numerous mRNA and protein products can arise from a single gene locus, and incorrect regulation has been implicated in numerous diseases. While many robust methods exist to study genome-wide single exon splicing patterns, no …
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Neuromuscular Synaptic Proteins In Development And Regeneration
… with their developmental targets. While the molecular pathways that govern peripheral nerve development and neuromuscular synapse formation are mostly understood, it is unclear whether the same pathways are reemployed to promote regeneration. For example, neuromuscular synapses form through …
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Genetic Characterisation of Human ABO Blood Group Variants with a Focus on Subgroups and Hybrid Alleles
… The overall aim of this study was to compare the molecular diversity of ABO alleles with various phenotypes, and to contribute to our knowledge of the ABO gene and encoded glycosyltransferases. Novel alleles (six Aweak, eleven Bweak, seven O) were identified containing single-point mutations. …
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Systematics of the Endangered Mauremys mutica and Mauremys annamensis
… to have a tremendous amount of morphological and molecular diversity. In this study, I have used a combination of known-locality, farm, and trade seizure specimens to further investigate this claim that <em>M. mutica </em>is a complex of species. In addition, I have included a closely related …
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Heterogeneity in the Pitx2ON Population in the Mouse Superior Colliculus
… targets or whether subpopulations with distinct molecular or projection profiles exist. This work investigates heterogeneity within Pitx2ON neurons, starting with single-nucleus RNA sequencing to assess molecular diversity. Differential expression of transcription factors, neurotransmitter …
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Genomic tools for the management of European flat oyster (Ostrea edulis) stocks
… While previous efforts to measure genetic diversity and structure among O. edulis stocks have provided valuable insights, they have relied on a limited number of molecular markers. In an effort to expand our understanding of O. edulis genetic units and aid effective long term stock …
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Diversity and relationships of South Africa's fig-associated nematodes
… attention in South Africa. I have assessed the molecular diversity of nematodes present in the native South African species and discovered 24 undescribed species. Two were previously described but the descriptions need reviewing. I have revised one of these descriptions in Chapter 3 and Chapter …
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Synthesis and antibacterial evaluation of diverse small molecules
… First we extend organocatalysis to the field of diversity-oriented synthesis as a powerful means to generate molecular diversity and complexity in small molecule screening collections. We then study a family of potential biofilm inhibitors identified from a diverse screening collection, and for …
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Revealing the Mechanisms of Tumorigenesis Through Multi-Omics Analyses
… cancer phenotypes, offering insights into the molecular diversity of malignancies. Yet, a critical challenge remains: the inability to systematically trace tumor evolution from the very beginning to progression in humans, which hinders the development of targeted therapeutic strategies. To …
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