Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"molecular diagnostic"”.
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A Molecular Diagnostic Survey of Pathogens and Parasites of Honey Bees, Apis mellifera L., From Arkansas and Oklahoma
… data. </p> <p>In the research described herein, molecular diagnostics were performed on worker honey bee samples from Arkansas hobbyist beekeepers and Oklahoma migratory beekeepers to detect the presence of the following A. mellifera pathogens and parasites: protozoans Nosema apis and N. ceranae; …
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The use of molecular diagnostic methods to improve the detection of the common bacterial and viral causes of community acquired meningitis in children in South Africa
… aetiology, further compounded by routine viral diagnostics not being commonly implemented for meningitis diagnosis. We developed and validated in-house quantitative real-time (qPCR) multiplex assays to test for bacterial causes namely: Neisseria meningitidis (ctrA gene), Haemophilus influenzae …
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Integration of tunneling magnetoresistive sensors for high resolutive magnetic particle detection
… The integration of bionanodevices in the molecular diagnostic field leads towards improvements in our life quality by assuring fast and cheap diagnosis devices. Low cost production hand-held biochips are foreseen to be incorporated in the next generation of bionanodevices. Among them, …
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Spinocerebellar ataxia type 7 in southern africa: an epidemiological, molecular and cellular study
… the disease, developing improved approaches for molecular diagnostic testing, and establishing a model for in vitro studies of pathogenesis.
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Implementation Plan to Integrate the Nanosphere Verigene Assay in a High-volume Reference Laboratory and the Anticipated Workflow Benefits to Adopting Rapid Blood Culture Testing
… prolonged collection-to-incubation times. Rapid molecular diagnostic methods independent of culture results is an available potential solution. The focus of this paper is to consider published literature on the evaluation of rapid blood culture testing to identify its potential benefits and …
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Molecular Diagnosis of Lower Respiratory Tract Infection in the Paediatric Intensive Care Unit
… Firstly, I evaluated the use of microbiology and molecular diagnostic tests in a cohort of mechanically ventilated children and assessed the baseline use of antimicrobial therapy in the paediatric intensive care unit (PICU). I identified that lower respiratory tract infection (LRTI) was the …
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Molekulinė naminių pelėdų (Strix aluco) hemosporidinių parazitų diagnostika /
… aluco) with haemosporidian parasites using molecular methods. 3 objectives were set to achieve this aim: to investigate the prevalence of haemosporidian parasites in tawny owls (Strix aluco); to determine the species composition of haemosporidian parasites detected in tawny owls (Strix …
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Validation of a Pan-fungal polymerase chain reaction (PCR) assay for the detection and identification of medically important fungi in a diagnostic laboratory
… there has been an increase in the utilization of molecular diagnostic techniques for the detection and accurate identification of fungal pathogens. This was a laboratory accuracy study evaluating the performance of a selected pan-fungal PCR using 70 previously identified reference fungal isolates. …
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Improving Medicare & Medicaid Reimbursement Framework for Molecular Diagnostics Tests Using Gene Sequencing: A Case Study in Health Economics
… In the recent past, research has shown that molecular diagnostic tests have revealed that about 20% of the tumors carry the HER-2 mutation on cell surface, which can be treated with the drug Herceptin, or trastuzumab, improving cancer free survival rates from 71.9% to 84.2% in five years. …
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Barcoding and eDNA metabarcoding of a rapidly changing Neotropical freshwater fish community
… integrative taxonomy, DNA barcoding and other molecular diagnostic methods), associated with traditional taxonomic identification, are being increasingly implemented worldwide. Surprisingly, despite being a hugely biodiverse country, Brazil has not yet embraced these novel DNA-assisted …
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Systems approaches to identify molecular signatures from high-throughput expression data: towards next generation patient diagnostics
… and rapid measurement of virtually all molecular components within human cells, tissues, organs, and serum has led to the generation of a tremendous amount of raw information. However, converting large-scale data to essential knowledge on human health and disease mechanisms has been a …
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Digital amplification for pathogen detection in bloodstream infections from whole blood
… treatment of bloodstream infections. Sepsis, a diagnostic challenge of blood stream infections, causes thousands of deaths each year. The gold standard for detection and identification of microorganisms is blood culture, which can take up to 5 days to yield a diagnosis or a negative result. …
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Helminth, protozoan and viral infections of the European eel, Anguilla anguilla
… theriver Gowy confirmed the robustness of the molecular diagnostic test. Overall, T. granulosumwas found to be highly prevalent (87.2%) in UK eel.A PCR-based assay for detection of the Herpesvirus anguillae (HVA) DMA polymerasegene was also developed. Heart screening revealed that H. anguillae …
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Methylation analysis and diagnostics of Beckwith-Wiedemann syndrome
… 11p15.5. There are no generally agreed clinical diagnostic criteria, with molecular studies commonly performed to confirm diagnosis. In particular, methylation status analysis at two 11p15.5 imprinting control centres (IC1 and IC2) detects up to 80% of BWS cases. However, this is not without its …
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Mutation analysis of important retinal candidate genes: progression from research to diagnostic service
… to the identification of 10 families for whom a molecular diagnostic service can now be provided. For most families the amount of useful information available without further research is minimal, however for four of the families, therapeutic interventions may be possible, now or in the near …
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Exosomes and miRNAs in disease pathogenesis and opportunities for molecular targeting
… knowledge may lead to the development of novel molecular diagnostic approaches, as well as innovative drug delivery modalities for small RNA-targeted therapy. My research resulted in a) the establishment of new methods and approaches to the study of exosomes/EVs, as well as comparative …
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Plant Virus Diagnostics: Comparison of classical and membrane-based techniques for immunoassay and coat protein sequence characterization for Cucumber mosaic virus and three potyviruses
Diagnostics is important in the development and implementation of pest management strategies. The virus diagnostic capabilities of several plant pathology collaborators within the Integrated Pest Management Collaborative Research Support Program (IPM CRSP) host countries were evaluated with the aid …
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E. COLI STEC MONITORING IN A ONE HEALTH APPROACH.
… section details the rigorous sampling and molecular diagnostic techniques employed, including Real-Time PCR assays for detecting STEC serogroups. The study encompasses sample collection from various matrices, DNA extraction protocols, and validation of molecular methods to ensure …
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Surface enhanced Raman scattering based assays for DNA detection by
Surface enhanced Raman scattering (SERS) based molecular diagnostic assays for the detection of specific DNA sequences have been developed in recent years to compete with the more common fluorescence based approaches. Current SERS assays require either time consuming separation steps that increase …
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