Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"molecular determinants"”.
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Molecular Determinants of TRP Channel Gating
… phenotypes through a combination of molecular determinants. Chapter 4 includes a detailed discussion of these results. Taken together, these findings provide new insight into the mechanisms underlying TRP channel function, as well as reveal potential targets for modulating the …
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Molecular Determinants of Residual Disease In Ovarian Cancer
… clinical issue by identifying and validating molecular biomarkers that can predict the likelihood of residual disease in ovarian cancer patients. Using publically available databases and microarray datasets, we identify FABP4 and ADH1B as markers of residual disease since the high expression …
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Getting Insight into the Molecular Determinants of Foldopathies
The study of the molecular determinants of foldopathies is an urgent task to be addressed because of the huge number of people inflected by these severe diseases. Foldopathies are diseased linked to protein misfolding and include widespread diseases, such as Parkinson’s and Alzheimer’s disorders. …
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Molecular Determinants of Synaptic Vesicle Exocytosis and Endocytosis Coupling
… rapid synaptic transmission; however, the molecular mechanisms of this process are not well understood. This coupling is assumed to be Ca2+-dependent but the exact role of Ca2+ and its key effectors in the regulation of endocytosis are not clear. Using a genetically encoded pH-sensitive GFP …
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Molecular Determinants of Tumor Re-Initiation in Breast Cancer
… understanding of the biological features and molecular determinants that govern tumor-forming capacity in the primary and metastatic site is of great importance to the scientific and biomedical communities. This thesis presents an unbiased approach to systematically select and characterize …
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Physiological and molecular determinants of the Chlamydomonas reinhardtii pyrenoid
… prominent cellular features without a precise molecular or physiological definition. Under ambient CO2 , at least 90% of the cellular RuBisCO is packed into a dense matrix, together with the chaperone RuBisCO activase. Thylakoid membranes usually traverse the pyrenoid matrix, and the …
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Molecular determinants of mammary differentiation and breast cancer progression
… In this thesis, I have identified a number of determinants involved in breast cancer progression and mammary differentiation. First, I describe SMARCE, a SWI-SNF component, as a prognostic factor of carcinoma progression. We show that SMARCE1 cooperates with ILF3 to regulate a basement membrane …
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Investigations of the molecular determinants of maize streak virus replication
… iterons would therefore potentially act as the determinants of replication specificity amongst mastreviruses.
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Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
… experimentally, but inferences about the molecular mechanisms responsible for these biophysical properties are often indirect because the technique lacks the resolution to see structural features responsible for these phenomena. In order to link electrophysiological data to molecular …
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Variability of photosynthesis genes in purple bacteria and molecular determinants of their spectral properties
… (Rss.) parvum 930I, were investigated by molecular biological methods. Analyses were focused on their light harvesting (LH) 1 core antenna, which is encoded within the puf operon. The puf-operon of the purple sulfur bacterium Amb. purpureus differs from the puf operon of the purple …
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On the Origin of Phenotypic Variation: Novel Technologies to Dissect Molecular Determinants of Phenotype
… techniques applied to the dissection of molecular factors underlying phenotypic variation. The first part of my work is focused on finding rare genetic variants in pooled DNA samples, leading to the development of a novel set of algorithms, SNPseeker and SPLINTER, applied to …
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ELUCIDATING THE MOLECULAR DETERMINANTS OF P53-MEDIATED PLEIOTROPIC EFFECTS IN SMALL CELL LUNG CANCER
… peptidyl prolyl cis-trans isomerases as critical determinants of a p53-induced transcriptional program that is specific to SCLC tumors and cell lines that are poised to undergo p53-mediated necrosis. Importantly, inhibition of cyclophilin isomerase activity, or genetic ablation of specific …
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Specifying molecular determinants of the subcellular targeting of synaptic and extrasynaptic GABA A receptors
How GABA-A receptor subtypes segregate so precisely to different subcellular locations is not understood. In this study, I have expressed the recombinant g2 and d GABA-A receptor subunits in cultured hippocampal neurons to analyze the differential cell surface expression and sub-membrane …
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The Cellular and Molecular Determinants of Hippocampus Size in a Female Monkey Model of Depression
… of depression, though the cellular and molecular mechanisms contributing to those mechanisms are unknown. Reduced hippocampal volume is reported in depressed patients, yet the interpretation of human studies is confounded by subject heterogeneity. Although the hippocampus is functionally …
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Genotypic and Molecular Determinants in the Continued Evolution of West Nile Virus in the United States
… was to investigate both genotypic and molecular determinants involved in continued evolution of WNV by relating in silico and in vitro differences in the molecular epidemiology, population dynamics, and phenotypic properties of both natural and infectious clone-derived viruses. …
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Molecular determinants regulating Bruton’s tyrosine kinase activity and their mechanism: a combined computational and experimental approach
… combined with information theory and molecular dynamics, was used to identify a specific site in the Btk kinase domain that can be targeted to rescue the kinase activity of Btk in the presence of an inactivating disease causing mutation.</p> <p>The work presented here provides new …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
… mutagenesis and structural modelling, the molecular basis for the selective potentiation of α4β2 nAChRs has been identified. The potentiating binding site of dFBr is located in the top-half of a transmembrane cavity between the M3 and M4 helices of the α4 subunit. α4Y309, α4F312 and α4L617 …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
… mutagenesis and structural modelling, the molecular basis for the electi e potentiation of a4P2 nAChRs has been identified. The potentiating binding site of dFBr is located in the top-half of a transmembrane ea ity b tween the M3 and M4 helices of the a4 subunit. a4Y309, a4F312 and a4L617 …
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