Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"molecular clock"”.
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Design and Analysis of High-Stability THz Molecular Clock System
… and wireless networking. Recently, chip-scale molecular clocks (CSMCs) have achieved excellent stability performance by using a rotational-mode transition of gaseous carbonyl sulfide (¹⁶O¹²C³²S). Its low-cost implementation and robustness against external electrical/magnetic fields make a CSMC …
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Terahertz frequency synthesis in CMOS for a chip-scale molecular clock
Clocks are fundamental to modern communications, navigation, and sensing systems. A recently invented chip-scale molecular clock (CSMC) based on terahertz electronics could enable low-cost, atomic-grade timekeeping for applications that are poorly served by existing clock technologies. However, the …
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The human molecular clock and mutation process : a characterization using microsatellite DNA
… that microsatellites are useful as reliable molecular clocks, such that its evolution highly correlates to time, especially when applied to the time range appropriate for human history. Using existing models of microsatellites, we examine microsatellite data from populations around the world …
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Genome-scaled molecular clock studies of invasive mosquitoes and other organisms of societal relevance
Molecular dating (or molecular clock) is a powerful technique that uses the mutation rate of biomolecules to estimate divergence times among organisms. In the last two decades, the theory behind the molecular clock has been intensively developed, and it is now possible to employ sophisticated …
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Calculating the structure-based phylogenetic relationship of distantly related homologous proteins utilizing maximum likelihood structural alignment combinatorics and a novel structural molecular clock hypothesis
… program that employs a novel structural molecular clock hypothesis. The results from this methodology support the proposed hypothesis by demonstrating that generating dendrograms utilizing protein structures is superior to those generated utilizing exclusively protein sequences.
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Rates of Molecular Evolution and Phylogenomic Inference
… computational implementations of relaxed molecular clock models and the proposal of new models of rate changes across branches. The practical application of relaxed molecular clock models was further examined with the proposal of methods of model averaging and model selection for relaxed …
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Development of fish embryonic stem cell lines as tools for basic and applied studies of interest in aquaculture
… components (synchronising factors or input, molecular clock, rhythmic manifestations or output) is essential to understand the mechanisms of synchronisation, internal time measurement, response and anticipation to predictable environmental variations in living organisms, with circadian …
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Analysis of Circadian Rhythm Using a Novel SCN-Specific Cre Transgenic Mouse Line
… when most of the SCN neurons are without a molecular oscillator. The NMS-Cre(+);Bmal1flox/flox animals have essentially normal circadian rhythm of locomotor activity. Then, I generated NMS-Cre mediated Vesicular GABA Transporter (VGAT) conditional knockout animals because GABA has long been …
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Models of neurodegeneration using computational approaches
… monitor the oscillations of the peripheral molecular clock and behavioural rhythms in single Drosophila. Experiments were undertaken on wild- type and Aβ-expressing flies. The results indicate the robustness of the peripheral clock is not correlated with the robustness of the circadian sleep …
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Exploring SOD1 electron transfer, heterodimerization, and hetero-amyloid formation.
… a long-lived protein, it contains an intrinsic molecular clock, deamidation, that accumulates over time. Misfolding and aggregation of SOD1 have been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and, more recently, Parkinson's disease. To investigate the …
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Gene transfer history of carbon fixation proteins constrains marine cyanobacteria divergence times
… history. This work integrates gene transfer with molecular clock calibration methods to determine divergence times. Accordingly, I evaluate the relationship between atmospheric evolution and the ecology of important groups of phototrophs.
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Modeling Clonal Evolution with Branching Processes
… the number of neutral alleles can be used as a molecular clock to help us in this task.
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Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
… in cell signaling include protein folding, molecular trafficking, RNA splicing and cell cycle regulation among others. Bride of Doubletime (BDBT) previously designated as CG17282 in the flybase was identified as a circadian clock component that stimulates DBT’s circadian function. Here, we …
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A Phylogeographic Study of Arenaria ciliata and Arenaria norvegica in Ireland and Europe
… maximum likelihood, haplotype networks, and a molecular clock analysis using Bayesian inference. Amplified fragment length polymorphism (AFLP) markers were generated for all populations sampled using three selec- tive primers and the obtained data were analysed using neighbour- joining …
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The Archean origin of assimilatory sulfate metabolisms provides novel insight into redox conditions of early Earth environments
… chemical reaction. A phylogenetic and molecular clock analysis of the sat/ATP sulfurylase protein family (E.C. 2.7.7.4) was performed to determine the age of sulfate assimilation proteins. Extant diversity of sat proteins was estimated to have a last common ancestor ~3.24 Ga (95% CI …
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Clock-based segmentation in the red flour beetle Tribolium castaneum
… stages of Tribolium is based on a segmentation clock. Specifically, I show that the Tribolium primary pair-rule gene, Tc-even-skipped (Tc-eve), is expressed in waves propagating from the posterior pole and progressively slowing until they freeze into stripes; such dynamics are a hallmark of …
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A PHYLOGENETIC REEVALUATION OF THE GENUS GAVIA (AVES: GAVIIFORMES) USING NEXT-GENERATION SEQUENCING
… systematic relationships. Advancements in molecular techniques have improved avian phylogenetics and have led to new insights on the relationships between and within taxa. Loons (Aves: Gaviiformes) are one of the oldest living lineages of birds, and the order includes five extant species. …
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Taxonomy, Systematics and Biogeography of the Scaritinae (Insecta, Coleoptera, Carabidae)
… for the first time using morphological and molecular data. Analysis of morphological characters resulted in multiple equally parsimonious trees. Bayesian analysis supported a monophyletic Scaritinae and within Scaritini, a basal position of subtribes Carenina and Pasimachina. Relationships …
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Evaluating sleep and circadian rhythm disturbances and symptoms of impulsivity and inattention: Implications for adult attention-deficit/hyperactivity disorder
… circadian timing and the timing of the social clock – is a consistent predictor of poorer ADHD-like symptom outcomes. Furthermore, objective assessment of the rest-activity rhythm and sleep intervals of subjects show that a failure to precisely entrain to the 24 h circadian period is associated …
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Circadian desynchrony in the mouse: how does chronic exposure to rotating shift work-like patterns of light/dark affect circadian rhythms and neurobehavioural outcomes
… changes as a result of a round-the-clock activity regime might be. The present study examines male CD-1 mice treated with three different paradigms of rapidly rotating shift work-like light/dark manipulation compared to two control groups maintained on a standard 12:12 h light/dark …
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