Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 277 for “"molecular characterization"”.
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Molecular Characterization of Mth203 protein
In contrast to the wealth of molecular and biochemical information available concerning eukaryotic and bacterial replication, less is known about the molecular basis of replication initiation in archaea. In general, the archaeal proteins are simplified versions of their eukaryotic counterparts. …
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Molecular characterization of Mth203 protein
In contrast to the wealth of molecular and biochemical information available concerning eukaryotic and bacterial replication, less is known about the molecular basis of replication initiation in archaea. In general, the archaeal proteins are simplified versions of their eukaryotic counterparts. …
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Molecular Characterization of Male Breast Cancer
… to FBC, MBC is poorly characterized on the molecular level. Multiple global profiling studies of FBC have been performed on the genetic and epigenetic levels, while only a few genetic studies have been performed on MBC. The aim of the research presented in this thesis was to study MBC on the …
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Molecular characterization of ovine GM1 gangliosidosis
Ovine GM1-gangliosidosis is an autosomal recessive lysosomal storage disorder. Affected lambs are born relatively normal, however at approximately four months of age they begin exhibiting severe neurological symptoms. Pathology progresses rapidly in affected lambs ultimately resulting in death by …
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Molecular characterization of entamoeba histolytica tRNA genes
… Therefore, the present study determined the molecular characteristics of tRNA genes of E. histolytica in relation to the occurrence of diarrhea. METHOD: In this study, patients were recruited from rural pnmary health care clinics in Giyani, Limpopo Province and private clinics in Pretoria, …
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Molecular Characterization of the Human Alloimmune Response
When T lymphocytes from two individuals are placed in a mixed lymphocytic reaction (MLR) and allowed to stimulate each other a powerful proliferative response is elicited, reflecting the degree of incompatibility at the major histocompatibiltiy loci. Such in vitro proliferations translate in vivo …
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Molecular Characterization of the Human Alloimmune Response
When T lymphocytes from two individuals are placed in a mixed lymphocytic reaction (MLR) and allowed to stimulate each other a powerful proliferative response is elicited, reflecting the degree of incompatibility at the major histocompatibiltiy loci. Such in vitro proliferations translate in vivo …
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Molecular Characterization of Glioblastoma Cancer Stem Cells
… present uniform histological phenotypes, the molecular determinants of the disease vary considerably between individual cases resulting in complicated prognosis. The heterogeneity, aggressiveness and rapid tumor relapse of GBM is believed to be sustained by cancer stem-like cell populations …
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Molecular characterization of the putative oncogene myeov
The myeov gene was identified using the tumorigenicity assay with DNA from a patient suffering a gastric carcinoma. The Myeov gene is localized at chromosome band 11q13, a frequent site for chromosomal rearrangements in various carcinomas and B-cell neoplasms. The gene was shown to be involved in …
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Genomic and Molecular Characterization of Brainstem Glioma
… features, aiming to understand the genetics and molecular biology of this disease. From DNA methylation data, we identified four distinct clusters termed H3-Pons, H3-Medulla, IDH, and PA-like, each associated with unique genomic and clinical profiles. The majority of tumors within H3-Pons and …
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Clinical and Molecular Characterization of Auditory Neuropathy
Auditory Neuropathy (AN) is diagnosed when the auditory brainstem response (ABR) is absent and outer hair cells (OHC) function normally, which indicates that the lesion lies in the inner hair cells (IHC), their afferent nerve’s synapse or the auditory nerve. While the presence of non-syndromic …
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Molecular characterization of phosphonate biosynthesis in nature
… PEP mutase (PepM). By using the pepM gene as a molecular marker for phosphonate biosynthetic capacity, I showed that phosphonate biosynthesis is both common and diverse across a wide range of environments, with pepM homologs detected in ~5% of sequenced microbial genomes and 7% of genome …
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Molecular characterization of three mental illness susceptibility genes
Bipolar disorder and schizophrenia are devastating mental disorders which share an overlapping constellations of symptoms, most notably the presence of psychosis. Overlapping genetic factors are involved in their pathogenesis and recently, genome-wide linkage scans and association studies have …
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Deep Molecular Characterization of Human Cortical Cell-Types
… dozens of morphologically, functionally, and molecularly distinct cell-types, the neocortex is organized into cytoarchitectonically and functionally diverse regions. In concert, the diverse cell-types that are found within the diverse cortical regions build the center of all higher cognitive …
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Molecular characterization of the lipidome by mass spectrometry
… cellular phenomena and disease states, the molecular mechanisms that underpin this structural diversity remain poorly understood. In part, this is due to the lack of adequate analytical techniques capable of measuring the structural details of lipid species in a direct, comprehensive and …
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Molecular Characterization of Dopamine Transporter Phosphorylation and Regulation
… neuron by a reuptake process. DAT is also a molecular target for psychostimulants such as cocaine, amphetamine (AMPH) and methamphetamine (METH) that increase DA synaptic levels either by blocking reuptake or by inducing DA efflux. DAT phosphorylation and transport down regulation are best …
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Molecular characterization of the Drosophila mitotic inhibitor Frühstart
Das Ziel dieser Arbeit war die biochemische, molekulare und genetische Charakterisierung des Drosophila Gens frühstart. In früheren Studien konnte bereits gezeigt werden, daß Frs als mitotischer Inhibitor wirkt, der spezifisch der Funktion der Protein-Phosphatase String entgegenwirkt, dadurch die …
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Molecular Characterization of Fluoroquinolone Resistance in Streptococcus pneumoniae
… of S. pneumoniae is a property that may help Molecular Characterization of Fluoroquinolone Resistance in Streptococcus pneumoniae prevent the emergence of resistance. The minimum inhibitory concentration (MIC) of moxifloxacin was < 1 pg/mL in 13 of 14 moxifloxacin-selected first-step mutants. …
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Cloning and Molecular Characterization of Novel Animal Papillomaviruses
… cancers. This thesis describes the cloning and molecular characterization of five new animal papillomaviruses: an equine cutaneous papillomavirus (EqPV); a canine oral papillomavirus associated with vaccine-induced carcinomas (COPV); an avian papillomavirus (PePV); an oral papillomavirus of …
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