Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"molecular binding"”.
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Mechanical Properties of Individual Molecules : An Interface between the Structure and the Function of the Molecules
… properties of individual molecules. The molecular receptor-ligand pair of avidin and biotin was used as a model system to establish our technique. Optical tweezers created the possibility to position the microsphere into close proximity of the surface and to define the local boundary …
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An isoperibol calorimeter for the investigation of biochemical kinetics and isothermal titration calorimetry
… to measure the enthalpy change associated with a molecular binding interaction. From these data, the binding constant for the reaction can be determined. In the scope of a larger project to design a high sensitivity instrument for collecting such data, the current methods in isothermal titration …
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Novel Applications of Biolayer Interferometry to Investigate Molecular Interactions
<p>In this study, BLI is used to explore various molecular interactions to demonstrate molecular binding and to provide quantitative characterization of binding kinetics and affinities of phage-protein and DNA-protein interactions. The results of this study demonstrate novel use of biolayer …
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Investigations into the Synthesis of InherentlyChiral Calix[4]arenes
… allows the lower-rim to act as a potential molecular binding site. Our objective is to develop methodologies and synthetic routes that allow us to generate a range of tetra-substituted, upper-rim functionalised calix[4]arenes in an AABC and ABCD pattern. We started by the selective …
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Electronic detection of molecules on the exterior and molecular transport through the interior of single walled carbon nanotubes
… of SWNT is readily disrupted even by a single molecular binding event. Hence, one of the promising SWNT applications has been sorption-based sensors utilizing the exterior. Conversely, the interior of SWNT can potentially be used as a frictionless molecular conduit due to graphitic surface …
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Design, Synthesis and Evaluation of FPR-1 Antagonists in the Treatment of Glioma
… would generate an inductive effect to weaken the molecular binding with surrounding residues. Additionally, introducing bulky groups should be avoided due to the spatial constraints of the binding pocket. Thus, this should be the template for further studies on improving the anticancer potency of …
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Scalable Gaussian Processes: Advances in Iterative Methods and Pathwise Conditioning
… scale regression, Bayesian optimisation, and molecular binding affinity prediction tasks. Additionally, generic improvements, which are applicable to any iterative linear system solver in the context of Gaussian processes, are contributed, leading to computational speed-ups of up to 72x …
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Heritability of Nociception and Antinociception in the Laboratory Mouse
… to drugs sharing neural circuitry if not molecular binding sites."
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INVESTIGATION OF BIOMOLECULAR INTERACTIONS FOR DEVELOPMENT OF SENSORS AND DIAGNOSTICS
… crucial biological processes. Uncovering the molecular basis of these interactions is of great fundamental and applied importance. This research work focuses on understanding the interactions of several biomolecular recognition systems and processes that can provide fundamental information to …
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von Willebrand factor interaction with subendothelial collagens and platelet surface receptor GPIBalpha under shear conditions
The molecular mechanisms of binding interaction among von Willebrand factor, subendothelium and platelets under physiological shear conditions are important medically in hemostasis and thrombosis. By binding both subendothelial collagens and platelet surface receptors GPIbalpha, multimeric vWf acts …
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Study of Dynamics on the Interfaces of Carbon-Based Nanomaterials and Nanobiosensor
… has shown capabilities to accurately simulate molecular binding processes in biophysics for instance. In this study, we seek the power of molecular dynamics simulation and computational docking to analyze the dynamics at various nano-interfaces including graphene amphiphilic Janus nanosheet …
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Development of novel chemical biology tools to probe malaria parasite physiology and aid in antimalarial drug discovery
… rational drug development. Unfortunately, the molecular targets of these drugs have not been identified. While both are thought to interact with parasite heme, linking in vitro heme binding with drug potency remains challenging because labile heme is difficult to quantify in live cells. This …
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MicroCantilever (MC) based nanomechanical sensor for detection of molecular interactions
… stress generation associated with chemical or molecular binding on functionalized microcantilevers. Formation of affinity complexes on cantilever surfaces leads to charge redistribution, configurational change and steric hindrance between neighboring molecules resulting in surface stress change …
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Single molecule studies of ligand-DNA interactions using atomic force microscopy
… results of experiments into the intra and inter-molecular binding of various ligands with dsDNA via the mechanism of intercalation, principally using the technique of atomic force microscopy (AFM). Since the description of the first AFM in the mid 1980’s, AFM has emerged as a sensitive and …
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Plutonium pharmacokinetics and blood biochemistry
… body. Two rather different areas relate to the molecular binding interactions which plutonium enters into in body tissues and transfer mechanisms from blood into cellular organelles. Very little is known about these processes and the speciation that plutonium demonstrates within the body. This …
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Lanthanides and quantum dots : time-resolved laser spectroscopy of biochemical Förster Resonance Energy Transfer (FRET) systems
… intracellular protein-protein interactions, molecular binding studies, in vitro diagnostics and many others. For qualitative and quantitative analysis, FRET systems are usually assembled through molecular recognition of biomolecules conjugated with donor and acceptor luminophores. Lanthanide …
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Magnetic forces for surface-based bioanalysis in microfluidic devices
… Each reagent stream contained reagents for a molecular binding assay and functionalised magnetic particles were deflected across the width of the chamber. As the particles were deflected through reagent streams, washing and reaction steps were performed on the surface of the particle in one …
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Konfokale Mehrfarben Einzelmolekülspektroskopie in Mikrokanälen zur Charakterisierung biologischer Proben
… analysis can be applied to detect and to analyze molecular binding events, as demonstrated in this thesis. The great advantage of this method in comparison to the widely used FCS-method is its sensitivity which lies in the sub-pM regime, as successfully demonstrated in this thesis. I performed …
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Printing methodologies for functional bioarrays
… functional bioarrays in order to study intermolecular interactions in confined environments and microarray format. In particular, inkjet printing was employed for the generation of picoliter-scale aqueous droplets stabilized against evaporation and molecular leakage by oil-confinement with …
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