Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"molecular barcoding"”.
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Towards optical connectomics : feasibility of 3D reconstruction of neural morphology using expansion microscopy and in situ molecular barcoding
… and ability to read out information-rich molecular signals. However, conventional optical microscopes have limited spatial resolution due to the diffraction limit of light, requiring a tradeoff between the density of neurons to be imaged and the ability to resolve finer structures. A new …
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Single molecule methods for clinical biomarker quantification
… on the identification of sensitive and specific molecular indicators of disease. As our understanding of these biomarkers continues to advance, the ability to quantify low abundance biomarkers from small sample sizes has become increasingly important for characterizing new targets and expanding …
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Studying the Clonal Origins of Drug Resistance in Human Breast Cancers
… will outline experiments using high complexity molecular barcodes to trace the fate of individual cellular clones in the development of drug resistance. With this technique, cellular clones can be uncoupled from their genomic backgrounds, giving a new depth to our understanding of clonal …
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ASCL2 Positive Tumor Cells Modulate the Response of Metastatic Colorectal Cancer to MAPK-Targeting Therapy
… CRC models, clinical data, engineered models, molecular barcoding and next generation sequencing to elucidate novel mechanisms contributing to MAPKi limited durability. We show that MAPKi therapy results in the enrichment of stem-programs in patient tumors, and demonstrate ASCL2 expression …
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Genetic Evolution and Prognostic Determinants of Pancreatic Cancer On Longitudinal Liquid Biopsies
… This precludes the opportunity for elucidating molecular underpinnings of cancer recurrence, chemoresistance, and therapeutic decision-making in advanced disease patients over the course of their therapy. For this reason, we aim to use so called “liquid biopsies” in the form of circulating …
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A taxonomic revision of the squat lobsters (Anomura: Chirostyloidea and Galatheoidea) of South Africa
… sampling to carry out morphological analyses and molecular barcoding where possible. These methods were used to add to, revise and update the regional fauna. The thesis is presented in the form of six chapters, four of which each revise one of the families of squat lobsters present in South Africa …
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Contributions to the taxonomy of South African hermit crabs (Crustacea: Decapoda: Paguroidea) – integrating microCT scanning and barcoding
… tomography (µCT) visualisations, and molecular barcoding to add to, revise, and provide an updated listing of, the regional fauna. The first section of the thesis comprises four chapters, each giving a detailed account of a species either new to science, or to the region. The pagurid …
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A preliminary integrated-taxonomic review of a staphylinid genus (Anotylus Thomson 1859) of the Ãrea de Conservacion Guanacaste, Costa Rica.
… being amongst the most poorly represented. Barcoding initiatives highlight taxa in need of revision and act as effective estimators of biodiversity using Barcode Index Numbers (BINs) as prospective species. This study acts as a preliminary review of a Staphylinid genus (the Anotylus) in …
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Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression during Immunotherapy
<p>Tumors are dynamic ecosystems that evolve under selective pressures, shaping their ability to either elicit or evade immune responses. In pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral …