Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"molecular architecture"”.
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Molecular architecture of the Saccharomyces cerevisiae kinetochore
(cont.) checkpoint proteins Bub lp and Bub3p are recruited to the kinetochore as part of the normal cell cycle in budding yeast, whereas Madlp and Mad2p are recruited only in response to damage to the CEN-kinetochore-MT connection. Analysis of specific S. cerevisiae kinetochore mutants indicates …
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GENOME-WIDE PROTEIN MOLECULAR ARCHITECTURE OF HUMAN PROMOTERS
… +1 nucleosomes exhibit a stable in vivo architecture, with paused Pol II embedded within these rotationally constrained nucleosomes. The rotational setting of the +1 nucleosome is influenced primarily by the periodic occurrence of specific dinucleotides but is also regulated by cofactors. …
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Molecular Architecture of the ER-Mitochondria Encounter Structure
… between the ER and mitochondria; however, the molecular architecture of ERMES components within these foci is unknown. Using integrative approaches including correlative light and electron microscopy (CLEM), live-cell and quantitative fluorescence imaging, as well as cryo-CLEM and subtomogram …
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Design of biopolymer-based networks with defined molecular architecture
… biopolymer-based hydrogel networks with defined architecture is presented. In order to obtain materials with defined properties, the chemoselective copper-catalyzed azide-alkyne cycloaddition (or Click Chemistry) was used for the synthesis of gelatin-based hydrogels. Alkyne-functionalized gelatin …
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Exploring the molecular architecture of proteins: Method developments in structure prediction and design
<p>Proteins are molecular machines of life in the truest sense. Being the expressors of genotype, proteins have been a focus in structural biology. Since the first characterization and structure determination of protein molecule more than half a century ago1, our understanding of protein structure …
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The Effects of Molecular Architecture on the Rheological and Mechanical Properties of Polymeric Systems
The roles of molecular architecture and end-group functionality on the surface segregation characteristics of branched polymers in blends with commercially available linear polymers were also investigated. In the blends of branched PEIs with polystyrene (PS), the surface migration of PEIs …
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Synthetic studies towards trichodermamide B: expedient synthesis enabled by arene oxide equivalents
… is a potent anti-cancer agent and with complex molecular architecture. It is hypothesized herein that this molecule may be derived in nature from phenylalanine via a benzene oxide intermediate. Utilizing a bioinspired strategy, synthetic studies towards trichodermamide B have been conducted …
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Detection of Polypeptide Interactions Via Periodate Triggered Dopa Crosslinking
… most biological function, yet elucidation of the molecular architecture within a cell still remains a formidable challenge for molecular biologist. We have developed a novel, bioorthogonal cross-linking chemistry based upon periodate mediated oxidation of the artificial amino acid 3,4- …
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Mechanophore-Linked Polymers for Studying Mechanochemical Response
… was found to increase linearly with increasing molecular weight. The analysis used for these studies will hopefully pave the way for future studies on the effect of molecular architecture on mechanochemical reactivity. Finally, we were able to realize a self-assessing mechanochromic material …
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Structural Studies of DNA Replication Machinery in Archaea
… to that of eukaryotes but presents a simpler molecular architecture. The aim of my thesis work is to use biochemical and biophysical methods to investigate the molecular basis of structure-function relationship, protein-protein interaction, and protein-DNA interaction in the archaeal DNA …
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Fundamental studies of polyelectrolyte multilayer films : optical, mechanical, and lithographic property control
… the PEM thickness, chemical functionality, and molecular architecture is made possible by changing the polyelectrolytes and assembly conditions during film growth, allowing films to be designed with properties suitable for a given application. This thesis elucidates the intra-film structure and …
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Part I: The synthesis of chenodeoxycholic acid derived macrocyles and cage compounds. Part II. Sonogashira coupling for the synthesis of well-defined π-conjugated arylene ethynylene oligomers as blue-light-emitting materials
… chenodeoxychoic acid (CDCA) derivatives and its molecular architecture was accomplished. A novel CDCA derivative with an ambient CO2 insertion to 7α-side chain has been serendipitously discovered. It is the first time that CO2 has been directly introduced to the steroid molecules by organic …
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Electrocatalytic CO2 Reduction by Self-Assembled Monolayers of Metal Porphyrins
… catalysts. We design a new heterogenous molecular architecture for CO2 electrocatalysts by attaching alkyne-terminated metal (Fe, Co) porphyrins via click chemistry to azide-terminated alkyl phosphate self-assembled monolayers (SAMs) on ITO and FTO electrodes. The electrochemistry of …
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Investigating coordinate network based films through mechanical and optical properties
… complexes have also been shown to be useful in molecular film formation [1 and 2]. This study investigates the mechanical and optical properties of tannic acid and 4 arm catechol polyethylene glycol based coordinate network films. It shows that these films can contribute to energy dissipation …
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Towards the total syntheses of aspidospermidine and aspidofractinine: the curious chemistry of the indolinyl radical
… within the class but also for their interesting molecular architecture. Herein, two routes towards the natural products are presented. Key features of the first route, a unified approach to both targets via the indolinyl radical, include the elegant construction of the core ABDE ring system, a …
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Three dimensional molecular architectures for the synthesis and improved properties of high performance polymers
… thesis, we investigate the effect of having a molecular architecture that is both rigid and three-dimensional might play in the synthesis and performance of conjugated polymers. We discuss the efficient synthesis of a hydrophilic monomer bearing a threedimensional noncompliant array of hydroxyl …
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Phase behaviors of ABAC tetrablock terpolymers
… and HEX cylinders are formed. Changing the molecular architecture from the ISO triblocks to the SISO tetrablocks drives the preference from the hyperbolic interfaces inherent in the network morphologies to the higher, and zero Gauss, curvature surfaces present in the core-shell spheres and …
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Block copolymer self-assembly and templating strategies
… core-shell structures) depending on the molecular architecture of the polymer and the volume fraction of its blocks. And in thin films, surface interaction and commensurability effect influence the self-assembly and result in more diverse morphologies including hexagonal-packed perforated …
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Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
… OF MISSOURI AT AUTHOR'S REQUEST.] The novel molecular architecture of dendrimers facilitates use in many applications. Using the solvatochromic probe phenol blue, the first direct examination of the polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimer core cavities was reported by a …
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Synthesis and Photophysics of Varied Substituted DPNDs for Potential PDT Applications
Understanding how molecular architecture and solvent polarity govern excited-state dynamics is fundamental to developing functional chromophores for photo-energy conversion and manipulation for opto-electronic applications. Here, the photophysical properties of three dipyrrolonaphthyridinedione …
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