Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"modulation of host"”.
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Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB
… spp. are gram negative bacteria capable of infecting a number of eukaryotic hosts. In humans, <em>Salmonella</em> infection can range anywhere from acute gastroenteritis to typhoid fever which can oftentimes be fatal.<em>Salmonella</em> are facultative intracellular pathogens that have …
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Bacterial modulation of host glycosylation - in infection, biotechnology, and therapy
A majority of the proteins of the immune system are glycosylated and the glycans of IgG are essential for its functionality. Bacteria display enzymes that modulate the glycans of the immune system to weaken the host defense and favor bacterial survival. In this thesis we aimed at exploring …
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Modulation of host metabolism by the human gastric pathogen Helicobacter pylori
… retaining cellular viability and functions, and often manipulated by bacterial pathogens as an effective target for remodeling the host environment for colonization. Helicobacter pylori, a human gastric pathogen that impacts more than a half the human population as the only recognized biological …
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Modulation of host NF-[k̳̳a̳p̳p̳a̳]B pathway by the Toxoplasma gondii secreted factor, GRA15
… blooded animals, including nearly thirty percent of the human population worldwide. Toxoplasma's success as a parasite owes largely to its ability to commandeer its host's immunologic and metabolic processes for its own benefit. During infection, Toxoplasma secretes a large number of proteins into …
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Anti-inflammatory drugs for modulation of host response to biomaterials and application in diabetes therapy
Host response to implanted biomaterials and medical devices poses tremendous challenges to their clinical applications. Today, the quest to mitigate this immunological attack for improved longevity of these devices remains daunting. This thesis aims to explore the use of anti-inflammatory drugs in …
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Modulation of Host BRD4 to Repress HIV Replication in Myeloid Cells: Major HIV Reservoirs in Central Nervous System
… (ZL0580) that induces epigenetic suppression of HIV. Here, we examined the effects of this compound on HIV in human myeloid cells. We found that ZL0580 induces potent and durable suppression of both induced and basal HIV transcription in microglial cells (HC69) and monocytic cell lines (U1 and …
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Molecular bases for modulation of host cellular responses by porcine reproductive and respiratory syndrome virus non-structural protein 11
… industry worldwide. In the present study, the modulation of host cell responses by PRRS virus (PRRSV) has been investigated. Non-structural protein 11 (Nsp11) contains a nidovirus-specific domain designated as NendoU, and this domain is known to have a endoribonuclease activity. This RNase …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
One of the first and fast line of defense launched by mammalian hosts to counter virus infection is production of type I interferon (IFN), an innate immune response that generates antiviral state to prevent virus replication and spread by expressing several IFN-stimulated genes. Type I interferon …
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Investigating cestode modulation of host neuronal excitability and cell-type-specific gene expression in an in vitro mouse model of neurocysticercosis
… when viable larvae are thought to suppress host inflammation. Seizures tend to occur when larvae die and immune suppression ceases, which has led to the hypothesis that the host's immune response contributes to seizures in NCC. Further research is required to better understand the effects …
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Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response
… undefined reprogramming strategies including modulation of host gene transcription. In this study, we demonstrate that the E. chaffeensis effector TRP47 enters the host cell nucleus and binds regulatory regions of host genes relevant to infection. TRP47 was observed in the nucleus of E. …
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Toxoplasma gondii-mediated Host Cell Transcriptional Changes Lead to Metabolic Alterations Akin to the Warburg Effect
… gondii can cycle between primary and secondary hosts, thus enabling widespread penetrance. Within its intracellular niche – a membrane-bound parasitophorous vacuole – T. gondii is nevertheless able to subvert a variety of host cell processes to allow its continued survival and replication. This …
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Quantifying the Effect of Vitamin D Deficiency and Alcohol Exposure on Immune Response to Mycobacterium Infection
The goal of the May Multiscale Immunobiology Design, Algorithms, & Simulation (MIDAS) Lab is to develop dynamic empirical and simulation-based models of host-pathogen interactions to further our understanding of the mechanisms guiding immunologic response. Previous studies on the role of vitamin D3 …
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Rodent inflammasome activation by Toxoplasma gondii
… is an obligate intracellular pathogen capable of chronically infecting nearly all warm-blooded animals, including humans. The chronic stage is characterized by the presence of semi-dormant cysts in brain and muscle tissues. These cysts are crucial in the success of Toxoplasma as they are orally …
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Characterisation of Escherichia coli of the bovine intestinal tract
… (EHEC) are important gastrointestinal pathogens of humans. E. coli serotype O157:H7 is the EHEC most commonly associated with human illness. E. coli O157:H7 is carried asymptomatically by cattle which form an important reservoir for the bacterium. E. coli O157:H7 has been found to colonise at the …
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Functional Characterization of Bacterial Strains Enriched in Colon Adenomas and Their Impact on Colonic Epithelial Cells
Colorectal cancer (CRC) is one of the most common malignancies worldwide and a leading cause of cancer-related mortality. It arises from the progressive accumulation of genetic and epigenetic alterations in the epithelial cells lining the colon or rectum, often evolving from precancerous lesions …
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Cellular interactions of the cytolethal distending toxins
Over the course of evolution, pathogens have adapted and co-evolved with their respective hosts, with infectious diseases being one of the leading health concerns. Pathogens have developed several strategies to colonize the host, of which only a few have been characterized in molecular details. …
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Investigating cytokine responses to different strains of Mycobacterium tuberculosis
… tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the world's most prevalent fatal pathogens, infecting one third of the global population. The highly specialised pathogen that infects humans today evolved from a group of bacteria, known as the Mycobacterium …
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The effect of gender on Helicobacter pylori and gastric cancer
Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium has been classified as a type 1, or definite, carcinogen by the International …
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Fasciola hepatica cystatins: recombinant production, biochemical characterisation and efficacy as vaccines
… trematode (flatworm) Fasciola hepatica, is of major global economic importance in ruminants, such as cattle and sheep, and is now recognised as an important zoonosis. Following ingestion by the mammalian host, the parasite migrates through the intestinal wall and develops within the host …
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Understanding the function and structure of herpes simplex virus type 1 pUL55, a novel immune evasion protein
… virus-1 (HSV-1) infects approximately 67% of the human population, causing disease ranging from asymptomatic to severe. The virus affects individuals around the world, and results in lifelong infection. This work focusses on pUL55, a HSV-1 tegument protein, which we hypothesised to be an …
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