Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"modified mRNA"”.
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DEVELOPMENT OF A VACCINE FOR LYME DISEASE USING THE NUCLEOSIDE-MODIFIED mRNA-LNP PLATFORM
… the lipid nanoparticle-encapsulated nucleoside-modified mRNA (mRNA-LNP) platform to generate a Lyme disease vaccine like the successful clinical vaccines against SARS-CoV-2. Of the antigens expressed by Borrelia burgdorferi, the causative agent of Lyme disease, outer surface protein A (OspA) is …
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The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
… we show that a novel vaccine, nucleoside-modified mRNA encapsulated in lipid nanoparticles (mRNA-LNP) encoding influenza hemagglutinin, overcomes maternal antibody inhibition by prolonged establishment of germinal centers. mRNA-LNP vaccination offers a promising means of eliciting …
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Myc and Cyclin T1 co-expression as a therapeutic strategy for cardiac repair following myocardial infarction
… mouse model setting and from a bicistronic mRNA vector could drive adult rodent cardiomyocyte cell-cycle re-entry in the context of injury and lead to functional improvement. Methods Whole-heart single-nuclei RNA sequencing (snRNAseq), in vivo experiments, histology methods, and molecular …
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Modelling Huntington’s Disease Using Direct Cell Reprogramming
… that differentiate into neurons using chemically-modified mRNA (cmRNA) encoding the neural development factors SOX2 and PAX6. Importantly, cell reprogramming enables the study of early disease mechanisms and could facilitate the identification of novel therapeutic interventions for HD. The work …
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Investigating three-dimensional (3D) gelatin methacryloyl (GelMA) hydrogel as a potential scaffold for cell transplantation in Huntington's disease
… dermal fibroblasts using SOX2/PAX6 chemically modified mRNA, which were shown to differentiate into striatal neurons in vitro and in vivo. However, the current delivery approach in liquid suspension exposes the cells to mechanical stress during the injection. Therefore, encapsulating the cells …
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Effects of maternal supplementation of trace minerals and fatty acids on beef progeny
… subsequent calf growth performance as well as mRNA expression in longissimus muscle (LM) and subcutaneous adipose tissue at birth and weaning. There was no difference (P ≥ 0.34) in cow BW or body condition score from pre-supplementation through weaning. Relative concentrations of C18:3n-3 and …