Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"model-assisted design"”.
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Dual-Criterion Dose Finding Designs for Phase I Clinical Trials
… address this issue, we proposed dual-criterion designs that find the MTD based on both DLT and non-DLT-caused intolerance. These include a model-based design and model-assisted design that allow real-time decision making in the presence of pending data due to long event assessment windows. We …
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Novel Phase I/II Designs for Cytotoxic and Cytostatic Agents, and Combination Treatments
… innovative Bayesian adaptive dose-finding designs for early-phase oncology trials, aiming to improve the identification of optimal biological doses (OBDs) by jointly modeling safety and efficacy. Unlike conventional Phase I designs that rely solely on binary toxicity outcomes to estimate …
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Bayesian Adaptive Designs and Versatile Software Platform For Early Phase Clinical Trials
… to improve the efficiency of Bayesian adaptive designs for early phase clinical trials. Phase I clinical trials can be conducted using algorithm-based (also known as rule-based), model-based, or model-assisted designs. Numerous studies have shown that model-assisted designs have the simplicity …
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Bayesian Designs For Early Phase Clinical Trials With Novel Target Agents
<p>My dissertation mainly focus on Bayesian designs for early phase clinical trials with novel target agents. It includes three specific topics: (1) reviewing novel phase I clinical trial designs and comparing their operating characteristics; (2) Proposing a Bayesian optimal phase II clinical trial …