Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 195 for “"model organisms"”.
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Toxicity evaluation of new engineered nanomaterials in model organisms
… su organismi acquatici impiegati come modello, mediante saggi ecotossicologici a breve e lungo termine, la ricerca di specifici biomarkers di esposizione mediante analisi immunoistochimica, western-blotting e analisi dell espressione genica.
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Developing oleaginous yeast as model organisms for lipid production
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Elucidating the mechanistic impact of single nucleotide variants in model organisms
… four understudied kinases to show that predicted models closely resemble true specificities. We further demonstrate that this method can be applied to different organisms and can be used for other phospho-recognition domains. The described approach allows for an extended repertoire of sequence …
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Computational Methods for Accelerated Discovery and Characterization of Genes in Emerging Model Organisms
… and structure of cilia are conserved across all organisms with cilia. One of the most influential model systems used to study ciliopathies has been the ciliated green alga <italic>Chlamydomonas reinhardtii</italic>, an organism for which there is a sequenced genome with relatively few …
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Integrative transcriptomic approaches to analyzing plant co-expression networks
… (Stuart et al., 2003; Bergmann et al., 2004). Model organisms, such as Arabidopsis, are readily used in basic research due to resource availability and relative speed of data acquisition. A major goal is to transfer the acquired knowledge from these model organisms to species that are of …
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Neuropeptidomics Across Metazoan Life
… across metazoa, and thus working with simpler model organisms can provide valuable insights into the fundamental principles in the human brain. Several animal models have been commonly used in neuroscience studies, with each having specific advantages for particular research areas. For example, …
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Gene Regulation by a Novel Two-Component System Conserved Among Gammaproteobacteria
… in entomopathogenic bacteria, including our model organisms <em>Pseudomonas entomophila</em> and <em>Pseudomonas aeruginosa, </em>and is homologous to the recently identified two-component system, CrbRS, in <em>Vibrio cholerae.</em> In <em>V. cholerae</em> CrbRS regulates acetate metabolism …
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A systems approach to identify novel ageing regulators in Caenorhabditis elegans
… can influence ageing, experimentalists turned to model organisms in which they can measure longevity by studying survival curves. A major hurdle in such studies is that model organisms can live up to several years, as is the case for mice. Wild-type strains of the nematode C. elegans live just …
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Cytochrome P450 1A1 and aromatase (CYP19) in cetaceans : enzyme expression and relationship to contaminant exposure
… species, with reference to experimental work in model organisms, could determine the relative susceptibility of cetaceans to contaminant exposures. Aromatase is the enzyme responsible for estrogen production and recent studies suggest that PCBs may alter its activity or expression. We determined …
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Building an In-vitro Cell Model to Study Cellular Basis of Maturation Timing: A Proof of 3D Cell Culture Methodology in Atlantic Salmon Adipose Tissue
… been successfully utilized more accurately in model organisms, e.g., to understand cellular modular functions. However, the applications in non-model organisms are limited, and to our knowledge have not been implemented in ectotherms. At an ecological scale, the technique can enhance our …
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The Biological Age in British Agricultural Virology, 1920s-1960s
… around two perspectives: first, the study of model organisms such as tobacco mosaic virus through experimentation, and second, an emphasis on the continuing relevance of collections and comparisons between datasets derived from these collections in the twentieth-century life sciences. The …
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Effects of resveratrol on development of three lepidopteran species varying in diet breadth
… and development studies on many different model organisms, including several insect species. Results from these studies have been inconsistent across species; these inconsistencies may reflect the fact that many of these model organisms do not encounter resveratrol in their natural diets. …
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Functional Labeling of Individualized Post-Synaptic Neurons using Optogenetics and trans-Tango
… analysis tools available across different model organisms, but currently the field lacks a comprehensive method that can 1) target post-synaptic neurons using a pre-synaptic driver line, 2) assess post-synaptic neuron morphology, and 3) test behavioral response of the post-synaptic neurons …
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Image Registration and Gantry Tracking System of Clytia hemisphaerica
… requires detailed behavioral analysis of model organisms such as the jellyfish Clytia hemisphaerica. However, its size and rapid, free-swimming nature pose significant tracking challenges. This work presents a platform for the XY gantry system developed to overcome these hurdles for …
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Precursor-directed biosynthesis of non-natural berberine and galanthamine analogues
… galanthamine-producing daffodils are chosen as model organisms to evaluate these novel techniques in plants. The synthetic targets chosen as primary precursor analogues to produce fluorinated berberine and galanthamine analogues are 5-fluorodopmaine, 2-fluorodopamine, 3-fluorotyrmaine, and …
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Leveraging high-throughput datasets for studies of gene regulation
… development of the human body, as well as of the model organisms mouse and yeast. Firstly, I tackled biological questions with machine learning techniques by studying pre-transcriptional gene regulation through nucleosome positioning, which resulted in the identification of function-specific …
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Classifying drug-induced epileptic seizures in zebrafish larvae
Zebrafish (Danio rerio) is one of the model organisms used for epilepsy research and have been found to have enormous potential for modelling acute seizures and genetic epilepsies. In this project, a mathematical classification model was created with the aim of correctly classifying zebrafish …
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Science of science: Biological research network
… analysis techniques and find the importance of model organisms and humans in biological research. Based on these findings, we analyze whether these species are treated differently in biological research. On a global scale, we try to predict sleeping beauty species that may become important in …
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