Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 377 for “"model organism"”.
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Human canalization and female growth buffering with Drosophila as a model organism
… utilizes an evolutionary female canalization model to broadly contextualize observed instances of sex-specific growth outcomes. The objectives of this research are to: (1) investigate sex-specific differences in growth and development; (2) address contributing cultural factors of the target …
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Genetic Studies on the Circadian Clock in the Model Organism Drosophila Melanogaster
… and that may shed light on the gaps in the model. In an F1 screen for altered period length of the circadian locomotor activity cycle the new mutation 2ob9 was isolated. Cloning and sequencing identified the affected gene as a Drosophila homolog of the yeast RNA helicase and splicing factor …
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Analysis of Neuronal Diseases in the Model Organism <i>Aspergillus nidulans</i>
… beeinträchtigt ist. Zellen des filamentösen Pilzmodels Aspergillus nidulans wurden verwendet, um sich mit ungelösten Fragen beider Krankheiten zu beschäftigen. Sowohl Wildtyp αSyn als auch im Patienten gefundende mutierte Allele wurden heterolog im Pilz expremiert, haben das Pilzwachstum aber …
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Investigating the regulation of tumour associated lipogenesis using the model organism, Saccharomyces cerevisiae
The highly conserved mitogen activated protein kinase (MAPK) high-osmolarity glycerol (HOG) pathway plays a vital role in the ability of Saccharomyces cerevisiae cells to respond to stress conditions, primarily hyperosmotic stress. In addition, there is also evidence that the HOG pathway is …
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Physiological Characterization of Acetotrophic Anaerobic Respiration Using Anaeromyxobacter Dehalogenans as a Model Organism
… indicating a possible benefit of using these organisms for environmental clean-up. The ability of these organisms to successfully compete for nanomolar level acetate as the electron donor, in contrast to micromolar level required by methanogens, suggests that A. dehalogenans will successfully …
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Utilising Yeast as a Model Organism to Deconstruct the Regulation of Tumour Associated Lipogenesis
… Yeast is frequently used as a paradimic organism for the study of human diseases. In this study a Nile red assay has been developed, optimised and validated to measure levels of both polar and neutral lipids within yeast cells. This method has been utilised in the yeast species, …
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Mohria caffrorum (L.) Desv. : a new, unique model organism for the study of desiccation tolerance
Vegetative desiccation tolerance is the ability of a plant to dry to equilibrium with its surrounding atmosphere and remain in this dry state for prolonged periods of time. Upon rehydration, these plants are able to regain full physiological functionality. Vegetative desiccation tolerance is common …
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The actin-binding protein Drebrin and its implications for Alzheimer's Disease using the model organism C. elegans
… To analyse the interaction in vivo two novel models were designed, employing the nematode C. elegans. The Amyloid-β pathology was modelled by overexpressing the disease causing peptide pan-neuronally and employing a genetic sub-stoichiometric labelling method to be able to follow the …
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Cloning of "Animal Cryptochrome" cDNA from the Model Organism <i>CHLAMYDOMONAS REINHARDTII</i> for Functional Analysis of Its Protein Product
… a unicellular green alga, is a model organism to study the circadian clock. Cryptochromes are the blue light photoreceptors that entrain the clock in some organisms. The CPH1 protein of <i>C. reinhardtii</i> resembles the cryptochromes of the plant model <i>Arabidopsis</i>, but …
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Investigations into the relationship between behavioural tendencies and social status using the signal crayfish Pacifastacus leniusculus as a model organism
… signal crayfish (Pacifastacus leniusculus) as a model organism this study investigated if crayfish of differing social status display different behavioural tendencies. To this end size-matched dominant and subordinate individuals were tested for boldness and activity at different time points. The …
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Transposable elements: What have you done for me lately? A genomics based investigation into the potential functional roles of transposable elements using the model organism Caenorhabditis elegans
<p>The genomes of all organisms contain discrete DNA sequences present as disperse repetitive elements called transposons. Transposons have the unique ability to move to new chromosomal locations. Problems of uncontrolled movement of transposons can result in mutations, rearrangement, and even …
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Developing C. elegans as a model to study Type 2 Diabetes Mellitus
<p>Caenorhabditis elegans has been studied as a model organism in various areas of biomedical research because it shares many conserved functions at molecular and genetic levels with humans. Specifically, it is an ideal organism to study heterogeneous metabolic syndromes such as Type 2 Diabetes …
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Molecular Analysis of Roseburia Cecicola, a Motile Anaerobe, as a Foundation for Study of Bacterial Motility and Chemotaxis in the Murine Gastrointestinal Ecosystem
… bacterium Roseburia cecicola, is being used as a model organism in the study. Motility may be essential for this organism to colonize its specific habitat in the mouse cecum. I purified the main protein (flagellin) of the flagellar apparatus of the organism. The purified protein was then used in …
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Alzheimer's disease genes in zebrafish (Danio rerio) / Casper Groth.
… using the zebra fish (Danio rerio) as a model organism.
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Carabid Beetle Ecology as a Function of Disturbance in Temperate and Tropical Forests
… carabid beetles (Coleoptera: Carabidae) as the model organism group.
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Novel effects of Prefoldin Pathway on Intestinal Homeostasis via Dietary Restriction in Drosophila melanogaster
… is the maintenance of the intestines of the organism. Homeostasis of the intestines is controlled by the regulation of intestine cell apoptosis and intestine cell proliferation. My research explores the role of two protein subunits found in a complex which may have possible functions in the …
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Volumetric analysis of lamprey hydrodynamics using synthetic aperture particle image velocimetry
… vertebrate, this eel-shaped fish has served as a model organism for understanding locomotion control in vertebrates. Brain and spinal cord mappings of the lamprey nervous system are well characterized and share key features with neural systems across the animal kingdom. However, a comprehensive …
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Cell psychology
… the slime mold Physarum polycephalum as a model organism for studying cognition beyond the brain. Traditionally, psychology and neuroscience have tied cognitive abilities to nervous systems, but increasing evidence from aneural organisms suggests that cognition may be a broader, …
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Behavioral analysis and protein folding in zebrafish larvae
… Danio rerio, is a very important vertebrate model organism with growing popularity in biology and neuroscience. My thesis work covered two topics centered on zebrafish. Chapter 1 and Chapter 2 focused on the swimming behavior of the animal. This topic is of great interest because animal …
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