Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"model animal"”.
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Digestibility of Two Complete Pelleted Diets by the Horse (Equus caballus) as a Model Animal for Nondomestic Hindgut Fermenters
… nutrient and energy requirements of exotic animals is a necessary component of nutrition management in zoos and other wildlife facilities. In the absence of species-specific data, domestic animal models are often referenced. Herbivorous hindgut fermenters, such as horses, zebra, and …
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Using <i>Drosophila melanogaster</i> as a Whole-Model Animal System to Elucidate the Mechanism of Action of Novel Anticancer Agents
… their mechanism of action, an <i>in vivo</i> model system was developed using transgenic <i>Drosophila melanogaster</i>. Mutants were generated using the Gal4-UAS system coupled with RNA interference. Knockdown was achieved for <i>Sod1</i>, a key gene in the antioxidant pathway, and …
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DEVELOPMENT OF TRAPPING STYLE CASSETTES FOR NEW GENE TARGETING STRATEGIES
… have served for a long time as mammalian disease models. In particular, these last ten years have been the golden age for this favoured model animal. Human and mouse genome projects show that there is 95% genome homology. Spurred by this fact, research attention has shifted from reading these …
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Efeitos cronotropico e inotropico negativos induzidos pelo timol em ratos espontaneamente hipertensos
… induced by thymol in the SHR rats , an essential model animal of hypertension as well as in their normot ensive control WKY , by system organ technique in isolated vitro using the atria isolated from these animals. In SHR , thymol induced negative chronotropic effects ( pD 2 = 3.9 ± 0.029 ; E max …
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The effects of environmental nickel toxicity upon survival, growth, reproduction, fecundity, and lifespan of nematodes Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae
… heavy metal on living organisms. Nematodes are a model animal species that have been used in sediment and water testing of contaminated environmental samples. Nematodes lend themselves perfectly to liquid and sediment assays due to their easy recovery, handling, distinction between larva and …
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Multisector Mitigation of Plastic Pollution: Approaches from Biology, Policy, Law and Industry
… determining how plastic pollution harms marine animals and which measures should be used to reduce pollution. I use the four pathways to global sustainability (created by Folke et al., 2021) as a guiding framework for this dissertation because this framework outlines how society can develop …
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Mammary Window Chamber Model: A Platform For Multi-Modality Cancer Imaging And Dynamic Oxygenation Assessment
Window chamber models have served as a tool for optically visualizing a tissue environment over time. Their use throughout the years has furthered the study of cancer. However, optical imaging techniques utilized with the model are limited in the depth from which light can penetrate and signal can …
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Amino acid racemase responsible for the biosynthesis of D-aspartate and D-serine signaling molecules in Aplysia californica central nervous system
ABSTRACT While dogma states that animals use L-amino acids, several D-amino acids have been found in animals including humans since the 1980s. Two D-amino acids have attracted significant research interests because of their cell-cell signaling functions in animal nervous systems. D-serine (D-Ser) …
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Dietary Selenium in Cultured Hybrid Striped Bass
… impact the health and welfare of the farmed animal which has become of increasing concern to a more environmentally aware and health conscious consumer. New strategies must therefore be developed and adopted by the aquaculture industry to counteract negative consumer perceptions of industrial …
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Validation of the obese Ossabaw miniature pig as a model of the obese polycystic ovary syndrome phenotype with concomitant metabolic syndrome: exploration of polycystic ovary syndrome pathophysiology using in vivo and in vitro
… Many pre and post-natally androgenized animal models exist for this disorder but none completely recapitulate both the reproductive and metabolic features of the obese phenotype of PCOS with concomitant metabolic syndrome (MetS). Moreover, although PCOS is believed to arise from an …
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BEES AND WASPS IN A CHANGING ENVIRONMENT: MULTIPLE RESPONSES TO ANTHROPISED LANDSCAPES
… the need to include ecotoxicological tests on model animal organisms to authorise the spreading of the sludge. Future studies should consider the genetic basis of the observed variation to clarify whether the observed phenotypic shifts are the result of phenotypic plasticity or genetic …
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A tractable nematode model for the emerging fungal pathogen, Candida auris
… auris</em> are largely unknown.</p> <p>Current animal models of <em>C. auris</em> infections are not well standardized and report conflicting</p> <p>results. Additional animal models of virulence are needed, especially those amenable to high-</p> <p>throughput analysis. The nematode …
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Pathogenesis and Cross-species Infection of Hepatitis E Virus
… 3 and 4 infect humans and several other animal species including pigs and rabbits. An ever-expanding host range of genetically-diversified strains of HEV now include bat, fish, rat, ferret, moose, wild boar, mongoose, deer, and camel. Additionally, the ruminant species goats, sheep, and …
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Heterogeneous Nuclear Ribonucleoprotein K (Hnrnp K) Overexpression and Its Interaction With Runx1 Rna In Acute Myeloid Leukemia
<p>Acute myeloid leukemia (AML) is an often devastating hematologic malignancy with 5-year overall survival lingering near 20%. Acquiring a deeper understanding of molecular underpinnings of leukemogenesis will provide a basis for developing more effective therapeutic strategies for patients with …
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Microbial Metabolite Regulation of Microglial AHR Signaling in Alzheimer’s Disease
… progression. </p> <p>Methods: The Tg2576 mouse model was used for this study, in which mice develop amyloid plaques and cognitive deficits at 12 months of age. Mice were aged to 9 and 15 months to study the progression of AD from the pre-symptomatic and post-symptomatic time points. Cognitive …