Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"mitotic entry"”.
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Mathematical Modeling Reveals That G2/M Checkpoint Override
… 1 (mTORC1) plays an essential role to regulate mitotic entry after irradiation. Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… 1 (mTORC1) plays an essential role to regulate mitotic entry after irradiation. Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling …
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Mathematical Modeling Reveals That G2/M Checkpoint Override Creates A Therapeutic Vulnerability In Tsc2-Null Tumors
… 1 (mTORC1) plays an essential role to regulate mitotic entry after irradiation. Inhibition of the mTOR pathway delayed G2/M checkpoint recovery, while TSC2-null cells with hyperactivity of mTORC1 exhibited the opposite results. Furthermore, our mechanistic study revealed that mTOR signaling …
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Regulation of the Anaphase-Promoting Complex Examined at the Single Cell Level
… is an important regulatory transition leading to mitotic entry. I developed and characterized a fluorescent biosensor to measure the dynamics of APC-Cdh1 activity in single cells by quantitative time-lapse microscopy. I found that APC-Cdh1 is inactivated with very reliable timing, in contrast with …
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Peak Mitotic Cyclin Permits Mitotic Exit
… complexes promote replication origin firing and mitotic entry, and conversely, inhibit pre-replication origin loading and exit from mitosis. Cyclin synthesis and degradation, Cdk phosphorylation and Cdk inhibitors are controlled such that Cdk activity oscillates once per cell cycle. Little is …
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Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions
Alteration of mitotic gene function has recently been discovered to play a key role in tumor formation and cancer progression through the induction of chromosomal aberrations and genomic instability. Polo-like-kinase-1 is a critical mitotic regulator, overexpressed in human tumors, that functions …
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Genome-wide CRISPR Screening in FBXW7-mutant Cells Uncovers Multiple Druggable Synthetic Lethal Interactions Involving Cell Cycle Control
… stress and that ATR inhibition will force mitotic entry leading to mitotic catastrophe.
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Regulation and functions of Cdc14 in mitotic exit in Saccharomyces cerevisiae
… cell, the series of events that comprise the mitotic cell division cycle must be carefully regulated. Much of this regulation affects the transitions between the stages of the cell cycle, which are controlled by proteins known as cyclin dependent kinases (CDKs). High levels of CDKs promote …
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Identification of TICRR, a novel checkpoint and replication regulator
… the S/M checkpoint, leading to premature mitotic entry of cells with partially replicated genomes and mitotic catastrophe. Therefore, Ticrr is a novel cell cycle regulator essential for genomic integrity with roles in replication as well as in the S/M and G2/M checkpoints. We have …
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MAP kinase phosphatase-2 in vascular smooth cell muscle function
… between MKP-2 wild-type and knockout cells, mitotic entry was unaffected by MKP-2 deficiency which therefore diverted our study downstream to cytokinesis. Utilising time-lapse microscopy, smooth muscle cells lacking in MKP-2 exhibited a delay in cytokinesis and failure in abscission, …
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Exploration of Cell Cycle-Specific Essential Gene Functions in the Microbial Plant Chlamydomonas Reinhardtii
… two anaphase-promoting complex subunits, and the mitotic kinases Aurora B and MPS1. The phenotype of the cdka-1 mutant suggested a specific role for CDKA in the transition from cell growth to initiation of the S/M cell division program. CDKB, in contrast, functions specifically after DNA …
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Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycle
Aurora kinase A (AURKA) is a major mitotic regulatory kinase required for mitotic entry, the formation of a bipolar mitotic spindle, and the completion of cytokinesis. In recent years AURKA has been identified as an upstream regulator for many interphase functions such as cilia disassembly and …
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Targeting chromosomal instability: screening and characterization of CIN killers.
… those involved in JNK signaling pathways, mitotic cytoskeletal regulation and metabolic pathways. This screen demonstrates that it is feasible to selectively kill cells with CIN induced by spindle checkpoint defects. It has identified candidates that are currently being pursued as cancer …
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The Dynamics of the Unreplicated DNA Checkpoint in Xenopus laevis Embryos and Extracts
… the onset of nuclear envelope breakdown (NEB) at entry into mitosis. Also, experimental data was fit into the model while maintaining hysteresis and bistability. Therefore, the unreplicated DNA checkpoint model was updated with new interactions and experimental data while still preserving …