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Showing 1 to 17 of 17 for “"mitotic cell cycle"”.
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Mitotic cell cycle progression and differentiation of germline stem cells in Caenorhabditis elegans
In the C. elegans germline, stem cells make a decision to retain the germline proliferative cell fate or differentiate by entering meiosis. Importantly, this decision must be coordinated with progression through the mitotic cell cycle. Previous work has shown that the conserved GLP-1/Notch …
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Meiotic Dna Re-Replication And The Recombination Checkpoint
… Sic1, regulates the G1-S transition in the mitotic cell cycle and the analogous transition in meiosis. We have employed a form of Sic1, Sic1deltaP<sup>HA</sup>, that is mutated at multiple phosphorylation sites and resistant to degradation. Meiosis specific expression of …
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OVERT AND LATENT PATHWAYS OF POLARITY SPECIFICATION IN ZYGOTES: THE HAPLOID-TO-DIPLOID TRANSITION
… normal differentiation and function of diverse cell types, from unicellular prokaryotes to multicellular eukaryotes. Polarity specification, the establishment of an axis for directed growth and secretion, allows cells to achieve anasymmetrical state. This phenomenon is conveniently exemplified …
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Developmental regulation of DNA replication in Drosophila melanogaster
In mitotic cell cycles, the genome must be replicated fully in each cell cycle to ensure the normal complement of chromosomes. Failure to replicate chromosomes fully or a failure to limit replication to once-per-cell-cycle may lead to aneuploidy and genomic instability. Variants of the archetypal …
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The role of the chromosomal passenger complex and condensin complex in meiotic chromosome cohesion and segregation
The canonical mitotic cell cycle is modified in metazoans to achieve a variety of developmental goals. Among these, meiotic divisions reduce the DNA content of the cell, haploid gametes fuse and reenter mitotic cycling, and mitoses of early embryogenesis, in many animals, employ a rapid cell cycle …
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Cyclin-Dependent Kinase regulation and function during meiosis
… gametes are produced from a diploid progenitor cell. Accurate completion of the meiotic divisions requires a variety of modifications to the mitotic chromosome segregation machinery, which allow the reductional meiotic chromosome segregation program to occur. Oscillations in the activity of …
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Regulation of meiosis I chromosome segregation by Spol3 and Cdc5 in Saccharomyces cerevisiae
Meiosis is a specialized cell cycle that generates gametes for the purpose of disseminating genetic material to the next generation. The reduction of chromosome number by half is brought about two chromosome segregation phases following a single DNA replication phase. In the first division, …
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Gene expression changes during mammalian male meiotic initiation
In sexually reproducing organisms, germ cells can divide by mitosis, which generates daughter cells that are genetically identical to the mother cell, or meiosis, which divides the genome for haploid gamete generation. Germ cells undergo meiotic initiation, the transition from the mitotic cell …
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Chromosome dynamics of the early meiotic cell cycle in S. cerevisiae
In every cell cycle the genetic material must be duplicated and transmitted to the daughter cells. Meiosis is a developmental program that allows a diploid cell to produce haploid progeny. The reduction in chromosome number obtained during meiosis requires specialized mechanisms that are absent …
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Interrogating novel functions of the I kappa B kinases via CRISPR-Cas9 gene editing and small molecule inhibition
… signalling pathway is a critical mediator of the cellular responses to inflammatory cytokines. The IκB kinase (IKK) complex, which is composed of two catalytic subunits (IKKα and IKKβ) and one regulatory subunit (IKKγ/NEMO) acts as the master regulator of NF-κB transcription factor activity. …
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Insights into the regulation of the CRL4D̳T̳L̳ ubiquitin ligase
The eukaryotic mitotic cell cycle is a strictly ordered process by which cells accurately duplicate their genome and divide into two. Ubiquitin-mediated degradation of key cell cycle regulators ensures that the cell cycle phases progress in a unidirectional and orderly manner. Cullin E3 ubiquitin …
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A molecular characterization of the meiotic initiation factor STRA8 in mice
Sexual reproduction requires meiosis, a cellular division program in which one round of DNA replication precedes two rounds of chromosome segregation to produce haploid gametes. In most organisms, accurate meiotic chromosome segregation depends on the pairing and synapsis of homologous chromosomes …
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Differential Activity of The Kras Oncogene By Method of Activation: Implications For Signaling and Therapeutic Intervention
… mutations. An isogenic panel of colorectal cells with wild type KRas replaced with KRas G12C, G12D, or G12V at the endogenous loci differed in sensitivity to Mek and Akt inhibition. In contrast, screening was performed in a broad panel of lung cell lines alone and no correlation was seen …
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Sulforaphane Inhibits Mammary Cancer Cell Mitotic Progression and Tubulin Polymerization
… tumors in rodents, and more recently to induce cell cycle arrest and apoptosis in colon cancer cells. Here, we provide evidence that SUL also acts as a breast cancer antiproliferative agent. The BALB/c mouse mammary carcinoma cell line F3II was treated with SUL at concentrations up to 15 muM and …
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Control of M-G1 phase-specific expression in fission yeast
The mitotic cell cycle underlies propagation of eukaryotic cells, continually duplicating and dividing. The past few years have seen major advances in understanding of the regulatory mechanisms that impose on the cell cycle to tightly co-ordinate progression through its individual phases, …
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Regulation of Sister-Chromatid Cohesion
… execution of two critical events during the cell cycle--DNA replication and chromosome segregation--ensures the stable transmission of genetic materials. The cohesin complex physically connects sister chromatids during DNA replication in a process termed sister-chromatid cohesion. Timely …
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Analysis of the S. pombe sister chromatid cohesin subunit in response to DNA damage agents during mitosis.
… intact genome perhaps defines the purpose of the cell cycle, which is a complex, organized series of events pertaining to the production of daughter cells. Every eukaryotic cell undergoes two alternative life cycles mitosis or meiosis, the first producing identical daughter cells of a diploid …