Global ETD Search

Structural studies of the mitochondrial ribosome and co-translational insertion of membrane proteins

Desai, NirupaUniversity of Cambridge2019

… system to include mitochondrial ribosomes (mitoribosome) to translate these proteins along with other proteins which is species dependent. The mitoribosome is also involved in co-translational insertion of proteins destined for the inner mitochondrial membrane through binding of its …

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Biogenesis and Function of the Mitochondrial Ribosome

Palenikova, PetraUniversity of Cambridge2021

… ribosome. The mammalian mitochondrial ribosome (mitoribosome) is one of the largest ribonucleoprotein complexes in the cell, with the overall molecular mass of the fully assembled 55S monosome being ~2.7 MDa. It is indispensable for cell survival, as it translates 13 polypeptides encoded in …

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Protein factors involved in the biogenesis of the mitochondrial ribosome

D'Souza, Aaron RaynoldUniversity of Cambridge2018

… function of these modifications is unknown. Many mitoribosome biogenesis factors still remain to be identified and characterised. This work aims to broaden our understanding of two proteins involved in mitoribosome biogenesis through the study of the function of an rRNA methyltransferase and a …

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Mechanisms and Evolution of Mitoribosomal Small Subunit Biogenesis

Harper, Nathan

… in the mitochondria. The existence of these mitoribosomes points to the evolutionary origin of these organelles as proteobacteria which formed a symbiotic relationship with a host archaeal cell. The mitoribosome is responsible for translation of mitochondrially encoded respiratory chain …

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The role of RNA modifications in mitochondrial translation

Rebelo Guiomar, PedroUniversity of Cambridge2020

… aminoacyl site (A-loop of 16S mt-rRNA) of the mitoribosome large subunit (mtLSU), contacting the acceptor stem of incoming tRNAs, which indicates a potentially relevant role for the Um1369 modification in the translation mechanism. To understand the molecular role of MRM2, a genetic ablation …

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Unique Architectural and Evolutionary Features of the Mammalian Mitochondrial and the Plant Chloroplast Ribosome Revealed by Cryo-Electron Microscopy

Bieri, Philipp; id_orcid0000-0001-9031-2945ETH Zurich2017

ethz Repository record for Unique Architectural and Evolutionary Features of the Mammalian Mitochondrial and the Plant Chloroplast Ribosome Revealed by Cryo-Electron Microscopy (opens in a new tab)