Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"mitophagy"”.
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Cardiolipin Regulates Mitophagy Through The Pkc Pathway
… that are cardioprotective, such as autophagy/mitophagy and the mitogen-activated protein kinase (MAPK) pathways. My dissertation work focuses on elucidating how CL influences mitophagy and MAPK pathways.</p> <p>crd1Δ was synthetically lethal/sick with the general autophagy mutants atg8Δ, …
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Investigating how mitophagy is regulated by the metabolic context
… of mitochondria via macroautophagy, termed mitophagy, is a key quality control mechanism for mitochondrial network homeostasis, cell integrity and organism development. In mice, basal mitophagy is pervasive across mouse tissues, being particularly high in tissues of high metabolic demand. …
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Mitophagy in Heart Failure: A Selective Autophagic Degradation of Mitochondria
… induces selective degradation of mitochondria (mitophagy). We hypothesized that mitophagy contributes to remodeling of the heart under severe oxidative stress. METHODS: Mice were subjected to hemodynamic overload by severe thoracic aortic constriction (sTAC). qPCR was used to measure the …
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Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer
… mitochondria through autophagy, a process called mitophagy, is critical for maintaining proper cellular function. Much of the research elucidating the mechanism and regulation of autophagy was performed in yeast cells, so there is still a lot of mystery surrounding how mitophagy is promoted and …
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Investigating the role of the Nrf2-Keap1 pathway in mitophagy
Mitophagy prevents damaged mitochondria from compromising cell survival and homeostasis. Various mitophagy pathways have been discovered with the PINK1-Parkin pathway being most investigated. PINK1-Parkin mediated mitophagy occurs in stress-induced conditions. Interestingly, another pathway, the …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
… in cancer. Previously, we determined that the mitophagy receptor BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) is induced by IGF-1 to support mitochondrial turnover and protection. Here, we analysed a publicly available gene expression dataset of breast cancer cells …
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The Role of Parkin-Mediated Mitophagy During Aging and Exercise in Skeletal Muscle
… lysosomal degradation through a process termed mitophagy. Parkin is a ubiquitin ligase that is involved in mitophagy and the turnover of mitochondria. Parkin is extensively studied in neuronal tissue, but its role in skeletal muscle has not been fully explored. The overall purpose of this …
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Mitophagy-Mediated Regulation of ROS Homeostasis During HSC Activation Contributes to Cell Fate
… autophagy-defective models, the contribution of mitophagy to HSC function remains to be elucidated. Here, we capitalized on the observation that HSCs lacking the mammalian Atg1 homologues, ULK1 and ULK2, have a defect in mitophagy but no significant impairment in basal flux through the autophagy …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… biogenesis, while also inducing the mitophagy receptor B-cell Lymphoma 2 (BCL-2)/Adenovirus E1B 19 kDa Protein-Interacting Protein 3 (BNIP3). IGF-1 also activated the transcriptional regulator Nuclear Factor, Erythroid 2 Like 2 (NFE2L2/Nrf2), likely through inactivation of Glycogen …
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Reorganization of mitochondrial architecture during apoptosis and mitophagy as investigated by correlative microscopy
… architecture during two processes, apoptosis and mitophagy, in an effort to better understand the contribution of membrane remodeling to these biological processes. During apoptosis, Bax/Bak oligomerize and accumulate in and adjacent to the outer mitochondrial membrane, resulting in outer membrane …
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Identification of components required for mitophagy and mitochondrial inheritance by genetic screens in yeast
… mitochondrial turnover by autophagy, also called mitophagy. Mitophagy is a process ensuring the appropriate quality and quantity of mitochondria by sequestering a mitochondrion within a double membrane and delivering it to degradative organelles. Failed mitophagy in neurons is supposed to result …
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Be Eaten to Stay Healthy: Elucidating the Mechanisms of Mitochondrial Quality Control by Mitophagy
… of damaged mitochondria by autophagy, or mitophagy, has emerged as an important quality control mechanism. The Parkinson's disease related proteins phosphatase and tensin homolog-induced putative kinase 1 (PINK1) and Parkin have been identified as important regulators of mitophagy in …
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Determination of the Composition and Architecture of the Mitochondrial Ubiquitome in PINK1/Parkin Mitophagy
… by the autophagy system, in a process termed mitophagy. Through a positive feedback loop centred on the production of S65-phosphorylated Ub, PINK1 and Parkin work in concert to ubiquitinate proteins on the outer mitochondrial membrane, leading to the recognition, engulfment, and eventual …
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Skeletal muscle autophagy and mitophagy in response to high-fat feeding and endurance training
… of mitochondrial quality control, autophagy and mitophagy, may be suppressed in response to excess fat intake, but upregulated following endurance exercise training. These data may provide a mechanism for dietary and exercise-mediated regulation of mitochondrial quality and metabolic function. …
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Investigating the Role of msBDNF – TrkB Signaling in the Maintenance of Mitochondrial Populations Through the BNIP3 Mitophagy Pathway
… Bcl-2 nineteen-kD interacting protein (BNIP3) mitophagy pathway, although the relationship is not well-defined. BNIP3 localizes to the mitochondria and triggers a loss of membrane potential leading to mitochondrial destruction. Using a murine model, functional and dysfunctional mitochondrial …
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Analysis of PINK1/Parkin-related mitochondrial quality control in Drosophila
… the process of targeted mitochondrial autophagy (mitophagy) to prevent potentially catastrophic consequences. Such homeostatic mechanisms are particularly important for post-mitotic, energetically demanding tissues such as nerves and muscles. There is increasing evidence that failure of this …
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The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
… of PGC-1α in the regulation of autophagy and mitophagy during chronic muscle disuse in the form of denervation. To do this we denervated wildtype (WT), PGC-1α knockout (KO) as well as PGC-1α overexpressing (Tg) animals. We found that autophagy and mitophagy flux were compromised in KO animals …
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Mitochondrial Quality Control Adaptations Support Malignant Progression of Serous Ovarian Cancer Cells and Spheroids
… of quality control, mitochondrial dynamics, mitophagy, and mitobiogenesis. We have shown that aggregation of cancer cells supports increased mitochondrial fragmentation localized to the hypoxic core of our spheroid models. Further, aggregation supports enhanced viability through an …
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Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer
… Intriguingly, suppression of PNC1 impairs mitophagy in response to both mitochondrial depolarisation and hypoxia. We implicated disruption of the activity of the Nicotinamide adenine dinucleotide (NAD+) dependent deacetylase Sirtuin 1 (SIRT1) in this impairment of mitophagy/autophagy. …
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Autophagy in Zellweger Syndrome Spectrum Disorder and Cancer
… virus (virophagy) and of damaged mitochondria (mitophagy), and that disease-associated PEX13 mutants I326T and W313G are defective in mitophagy. The selective mitophagy function of PEX13 is shared with another peroxin family member PEX3, but not with two other peroxins, PEX14 and PEX19, which …
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