Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"mitogens"”.
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Tyrosine-Specific Protein Phosphorylation in Cells Transformed by Rous Sarcoma Virus or Stimulated by Mitogens
The transforming proteins of several RNA tumor viruses as well as a number of membrane receptors for polypeptide growth factors possess a tyrosine-specific protein kinase activity. Genetic and biochemical evidence indicates that this enzymatic activity is involved at the early stages of oncogenic …
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Stimulus-Mitosis Coupling in the Rat Thymic Lymphocyte
… for secretion and contraction in other tissues, mitogens show an intimate dependency upon the extracellular cationic environment for their activity. Subsequent work therefore investigated the redistribution of various cations across the plasma membrane initiated by mitogenic signals. Thirty …
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A Study of in Vivo and in Vitro Immune Responses of the A/j Mouse to Plasmodium Berghei
… through three experiments involving the use of mitogens, a soluble suppressive factor, and lymphoblast transformation studies with combinations of lymphoid cells. Three antigen preparations were used in the lymphoblast experiments: a soluble preparation of P. berghei, its ammonium sulfate …
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Pseudorabies Virus Infection of Porcine Peripheral Blood Leukocytes
… thymus). Lymphocytes stimulated with T cell mitogens, but not B cell mitogens, were permissive to PRV infection in vitro, as evidenced by the expression of PRV antigens on the surface of these cells and by the production of low titers of infectious PRV. Monocytes were highly permissive to PRV …
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Prostaglandins Modulate the Uterine Response to Infectious Bacteria in Postpartum and Estrous Cyclic Ewes
… infections. Lymphocytes were incubated with mitogens, PGE2, indomethacin (INDO; a PG synthesis inhibitor) or both in a 3 x 2 x 2 arrangement. Concanavalin A-stimulated blastogenesis in P4-OVEX ewes and PGE2 and PGE2+INDO treated lymphocytes was inhibited (P < .05). Cyclic ewes in their …
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Role of I Kappa B Kinase Alpha and I Kappa B Kinase Beta in the Development and Function of B and T Lymphocytes
… from these mutant mice in response to B cell mitogens was reduced due to impaired cell cycle progression. Accordingly, in vitro secretion of immunoglobulins by the mutant B cells in response to these mitogens was also decreased. In addition, these mice displayed selective defects in the …
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Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
… proliferation, and cell death. Extracellular mitogens or the binding of other ligands to cell-surface receptors begin a signaling cascade that activates MEK resulting in phosphorylation of its corresponding and specific and parallel ERK (Extracellular signal-Regulated Kinase) substrate. The …
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Effects of three-dimensional culture conditions on skeletal muscle myoblasts
… 3 and 6 days. This occurred in the presence of mitogens without exogenous matrix or support structures. Myoblast fusion was inhibited by exposure to soluble anti-Neural-cadherin antibody, but this treatment increased MHC levels assessed using immunohistochemistry.\r\nDuring early RCCS culture, …
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Design and Synthesis of CDK-5 and MEK-5 Inhibitors and Synthesis towards Tubulysin Analogs
… is upregulated in tumor cells and activated by mitogens; inhibition of this enzyme is a potential anti-cancer strategy. Scaffolds from the following classes--benzimidazole, diphenylamine, flavones, and ortho-carboxyamide were examined for their capacity to be developed into potent and selective …
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Induction of anti-ergotamine antibodies in mice and steers and protection against fescue toxicosis in mice
… Lymphocyte proliferation responses to mitogens in mice fed EI diets were similar to mice fed EF diets. Production of interferon gamma and interleukin-4 was higher by splenocytes from mice fed EI diets, whereas interleukin-2 tended to be lower. Fescue toxicosis may stimulate T helper …
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Immunomodulation by dietary lipids: soybean oil, menhaden fish oil, chicken fat, and hydrogenated soybean oil in Japanese quail (Coturnix coturnix japonica) and Bobwhite quail (Colinus virginianus)
… the FO fed birds had the highest response to all mitogens. In contrast, female BOB did not show any dietary effects by lymphocyte proliferation. Consistent with JAP, BOB fed HSBO had depressed lymphocytes proliferation in response to various mitogens stimulation. In general, female birds had a …
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Can levamisole upregulate the equine cell mediated immune response in vitro?
… cells were cultured alone, or with one of the mitogens: concanavalin A (ConA) or phorbol 12-myristate 13-acetate and ionomycin (PMA/I), or with a combination of the above mitogens and levamisole at several conditions. Cellular proliferation was assessed using a colorimetric bromodeoxyuridine …
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Transcription, Editing, and Switching of Antibody Genes
… The isotype choice is dictated by a variety of mitogens and cytokines produced during the immune response. In the first part of this thesis, I describe experiments that elucidate the role of DNA double-stranded break repair in class switch recombination. In the second part, I determine how …
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Characterisation of the molecular mechanisms of EGFR signal transactivation in human cancer
… concentrations of GPCR agonists such as the mitogens LPA and S1P as well as therapeutically relevant concentrations of cannabinoids. Moreover, this study reveals ADAM17 and HB-EGF as the main effectors of this mechanism in most of the cancer cell lines investigated. However, depending on the …
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Implication des hormones de croissance et du système CD95/CD95-ligand dans la tolérance fœto-placentaire
… of lymphoid cells, mainly T lymphocytes, by mitogens increases the expression of hGH-N-R. The comparative study of the effects of hGH-N and hPGH on cells from the human immune system had never been performed before. Our tests performed by the introduction of growth hormones at physiological …
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Experimental infection with Sarcocystis neurona alters the immune response: the effect on CD4+, CD8+, B-cell, monocyte and granulocyte populations in horses
… function was based on proliferation responses to mitogens, as assessed through thymidine incorporation. Enumeration of cellular subsets, degree of apoptosis and number of cellular divisions were assessed through flow cytometry. SnSAG1 ELISA of serum and CSF samples performed post-infection …
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Investigation of miRNAs Expression in a Citron-Kinase Mutant Model of Microcephaly
… NPCs upon removal of mitogens and addition of BDNF. Lastly, miRNA target prediction software was used to tabulate all highly predicted and verified gene targets for comparison with transcriptome analysis data. Gene targets of the down-regulated miRNAs in the MFBC …
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Studies on Lymphokine Activity in the Amphibian Rana Temporaria
… temporaria leucocytes, with both antigens and mitogens, was employed. The supernatants from such stimulated cultures were applied to assay systems, in which their effects on other leucocytes could be determined. Depending on the circumstances and kinetics of their production, a variety of …
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The role of anchorage in cell cycle control
Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. Failure to receive these signals results in either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint mechanisms. Transformed cells alleviate these …
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Non-Histone Nuclear Proteins : Patterns of Synthesis and Phosphorylation During the Cell Cycle, Redistribution at Times of Gene Activation and Properties of Subsets Interacting with HnRNA
… and in lymphocytes stimulated to proliferate by mitogens. These experiments lend support to the already substantial evidence that many of the nuclear proteins are intimately involved in the control of cell proliferation (Stein and Baserga, 1972; review). The second part describes the chemistry of …
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