Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 176 for “"mitogen-activated protein kinase"”.
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Regulation of ethylene biosynthesis by mitogen-activated protein kinase cascades in Arabidopsis
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT AUTHOR'S REQUEST.] Ethylene (C[subscript2]H[subscript 4]), a simple gaseous hydrocarbon, is an important plant hormone that has profound effects on plant growth, development, and response to environmental stimuli. Ethylene induces the …
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Diverse roles for the mitogen-activated protein kinase ERK2 revealed by high-throughput target identification
… to cancer in large part by activating the mitogenactivated protein kinases (MAPK) ERK1 and ERK2 (ERK). These kinases are critical in normal physiological processes from development to memory, and their activation in cancer drives growth and metastatic invasion. Understanding the effects of …
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Regulation Of Apoptotic Alkalinization Through Phosphorylation Of Sodium Hydrogen Exchanger Via P38 Mitogen Activated Protein Kinase
… demonstrated that a rise in intracellular pH activated apoptotic proteins leading to cytochrome C release. This "apoptotic alkalinization" occurred upon activation of the plasma membrane protein, sodium hydrogen exchanger-1 (NHE1), whose activity is regulated by the stress kinase p38 MAPK. In …
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Hypoxia-mediated human pulmonary arterial fibroblast proliferation is dependent on p38 mitogen-activated protein kinase activity.
… have been identified in the bone morphogenetic protein receptor II gene (BMPRII) (chromosome 2q32-31) a member of the Transforming Growth Factor (TGF) (Lane et al, 2000). Despite the mutation being present in all cells, vascular wall remodelling is only seen in the pulmonary circulation with …
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The Role of the Mitogen Activated Protein Kinase Pathway in Cisplatin and Noise-Induced Hearing Loss
… involved in both types of hearing loss and the mitogen activated protein kinase (MAPK) pathway is one. The MAPK pathway consists of a phosphorylation cascade with RAF, MEK1/2, ERK1/2 as the main three kinases that effect a multitude of cellular processes. The MAPK pathway has been associated …
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Effects of oncogenic Ras and p38 mitogen-activated protein kinase on the adhesion of normal human cells
… A growing body of literature links loss of p38 mitogen-activated protein kinase (MAPK) activity with the promotion of Ras-induced transformation in murine cells. Accordingly, I examined the effect of inhibiting p38 in normal human cells in which I also activated a low level of oncogenic Ras …
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Identification of a mitogen-activated protein kinase, p56, which mediates the self-incompatibility response in Papaver rhoeas L.
… Recent studies have revealed that p56, a mitogen-activated protein kinase (MAPK), is involved in activation of PCD during SI. MAPKs have been shown to be important signalling components in a range of cellular responses in eukaryotes. In Arabidopsis thaliana there are 20 MAPKs with roles …
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Genetic analysis of p38 mitogen-activated protein kinase signaling in innate immunity and stress physiology of Caenorhabditis elegans
… of multicellular organisms is the stress-activated p38 mitogen-activated protein kinase (MAPK) pathway. This thesis focuses on the physiological role of p38 MAPK signaling in the host defense of Caenorhabditis elegans. In Chapter Two, I report the identification and characterization of the …
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Polyunsaturated Fatty Acids and the Epidermal Growth Factor Receptor/ Mitogen- Activated Protein Kinase Signal Transduction Cascade in Mammary Cancer
Mammary cancer is one of the leading causes of death in both the human and companion animal population. There are many histological and pathophysiological similarities between human and feline mammary cancer, therefore investigating the molecular pathways of disease progression in one species may …
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Characterisation of the role of human Evolutionary Conserved Signalling Intermediate in Toll (ECSIT) in Mitogen Activated Protein Kinase (MAPK) signalling
Evolutionarily conserved signalling intermediate in Toll pathways (ECSIT) was identified orginally as a TNF receptor associated factor 6 (TRAF6) interacting partner. The murine homolog mECSIT has been shown to be involved in NFκB, MAPK, BMP and mitochondrial signalling. To date there is no work …
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Age-Related Effects on the Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Breast Cancer and the Characterization of Novel MEK5 Inhibitors
… changes in the extracellular signal-regulated kinases, ERK1/2 and ERK5, of the mitogen-activated protein kinase (MAPK) pathway, and in the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway. Further, the role of the MEK5-ERK5 cascade in breast cancer cell proliferation, migration, and …
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The Regulatory Role of Mixed Lineage Kinase 4 Beta in MAPK Signaling and Ovarian Cancer Cell Invasion
Mixed lineage kinase 4 (MLK4) is a member of the MLK family of mitogen-activated protein kinase kinase kinases (MAP3Ks). As components of a three-tiered signaling cascade, MAP3Ks promote activation of mitogen-activated protein kinase (MAPK), which in turn regulates different cellular processes …
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A Mechanistic Evaluation of how Melatonin Enhances Alkaline Phosphatase Activity in Human Adult Mesenchymal Stem Cells
… enhances osteoblast differentiation. The mitogen activated protein kinase signaling mechanisms has been implicated in osteoblast differentiation. Based on these findings, we hypothesized that melatonin acts through the mitogen activated protein kinase signaling cascade to enhance hAMSC …
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Lateral Membrane Domains Organize and Regulate Components of Signal Transduction Pathways
Components of the mitogen activated protein kinase (MAPK) signaling cascade also localized into domains in vesicles containing acidic lipids. The formation of lateral membrane domains induced by Ki-Ras 4B and the Raf-cysteine rich domain (Raf-CRD) was inhibited by the anti-tumor agent …
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On Microvascular Inflammation and Intestinal Leakage in Radiation Enteropathy
… of P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (CD162) abolished radiation-provoked leukocyte and platelet rolling in the colon. Moreover, inhibition of P-selectin and P-selectin glycoprotein ligand-1 also markedly decreased firm adhesion of leukocyte and platelets, suggesting …
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Anthrax toxin effects on B lymphocyte function
… that cleaves the N terminus of the mitogen-activated protein kinase (MAPK) kinase family 1-7, with the exception of MEK5. This kinase family is responsible for activating the mitogen-activated protein kinase (MAPK) cascade. This cascade includes extracellular signal-regulated protein …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
… Tribbles family of serine/threonine pseudokinases (TRIB1-3). Here, we studied murine haematopoiesis after Trib2 ablation under steady state and proliferative stress conditions, including genotoxic and oncogenic stress. At the steady state, we found that TRIB2 loss did not adversely affect …
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Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
… AR that is due to increased deposition of matrix proteins by mesenchymal cells that are increased in asthmatic airways, although the origin(s) of these cells are unclear. We have shown that two different strains of HRV, alone and in the presence of transforming growth factor-β1, caused phenotypic …
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Effects of Cadmium on VCAM-1 Expression
… Vascular cell adhesion molecule-1 (VCAM-1)의 변화와 Mitogen Activated Protein Kinase (MAPK) 저해제들이 VCAM-1의 변화에 미치는 효과를 관찰하였다. 그 결과, 카드뮴 처리 2시간째 VCAM-1 mRNA의 발현이 증가하였고 카드뮴 처리 4시간째에 VCAM-1 단백질 발현이 증가하였다. 그리고 이러한 부착분자의 발현변화가 어떤 세포신호체계를 경유하는지를 알아보기 위해 신호전달물질인 MAPK의 억제제를 사용한 결과, p38 MAPK 억제제 (SB202190)와 …
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